2024
Antagonism between neuropeptides and monoamines in a distributed circuit for pathogen avoidance
Marquina-Solis J, Feng L, Vandewyer E, Beets I, Hawk J, Colón-Ramos D, Yu J, Fox B, Schroeder F, Bargmann C. Antagonism between neuropeptides and monoamines in a distributed circuit for pathogen avoidance. Cell Reports 2024, 43: 114042. PMID: 38573858, PMCID: PMC11063628, DOI: 10.1016/j.celrep.2024.114042.Peer-Reviewed Original ResearchConceptsFLP-1 neuropeptidesBacterium Pseudomonas aeruginosa PA14Pathogen avoidanceGrowth factor BNematode Caenorhabditis elegansC. elegansCaenorhabditis elegansAvoidance signalPathogen infectionFlp-1NeuropeptidePathogensNeuronsMultiple mechanismsMultiple neuronsInfectionNeuromodulationPromote recoveryFactor BAvoidance behaviorAVKPA14Acatulides A-G, neuroprotective macrolides from Acaulium album H-JQSF
Tong Z, Wang T, Yang P, Sun J, Zhang C, Khan S, Wang X, Jiao R, Ge H, Zhuang W, Hu G, Tan R. Acatulides A-G, neuroprotective macrolides from Acaulium album H-JQSF. Chinese Chemical Letters 2024, 35: 108488. DOI: 10.1016/j.cclet.2023.108488.Peer-Reviewed Original Research
2016
Acute blockade of the Caenorhabditis elegans dopamine transporter DAT-1 by the mammalian norepinephrine transporter inhibitor nisoxetine reveals the influence of genetic modifications of dopamine signaling in vivo
Bermingham DP, Hardaway JA, Snarrenberg CL, Robinson SB, Folkes OM, Salimando GJ, Jinnah H, Blakely RD. Acute blockade of the Caenorhabditis elegans dopamine transporter DAT-1 by the mammalian norepinephrine transporter inhibitor nisoxetine reveals the influence of genetic modifications of dopamine signaling in vivo. Neurochemistry International 2016, 98: 122-128. PMID: 26850478, PMCID: PMC4969213, DOI: 10.1016/j.neuint.2016.01.008.Peer-Reviewed Original ResearchConceptsDAT-1Caenorhabditis elegansSwimming-Induced ParalysisNematode Caenorhabditis elegansGenetic mutationsPresynaptic DA transporterNovel genesHeterologous expressionDA releaseFunction mutationsGenetic modificationIon channelsElegansMutationsPresynaptic DA receptorsModulation of neurotransmissionGenesSWIPPhenotypeDA receptorsAcute blockadeDA transporterDA uptakeDA signalingExpression
2015
Untwisting the Caenorhabditis elegans embryo
Christensen RP, Bokinsky A, Santella A, Wu Y, Marquina-Solis J, Guo M, Kovacevic I, Kumar A, Winter PW, Tashakkori N, McCreedy E, Liu H, McAuliffe M, Mohler W, Colón-Ramos D, Bao Z, Shroff H. Untwisting the Caenorhabditis elegans embryo. ELife 2015, 4: e10070. PMID: 26633880, PMCID: PMC4764590, DOI: 10.7554/elife.10070.Peer-Reviewed Original ResearchConceptsCaenorhabditis elegansLate embryogenesisSeam cell nucleiSingle cell developmentNematode Caenorhabditis elegansEmbryonic nervous systemSystems-level viewWorm embryoInaccessible periodDevelopmental eventsCell developmentEmbryogenesisCell nucleiPositional informationElegansEmbryosLive embryosNeurodevelopmental eventsEmbryo movementAnnotation softwareCellsNervous systemEnough neuronsDetailed positional informationNeurons
2012
High-throughput fluorescence-based isolation of live C. elegans larvae
Fernandez A, Bargmann B, Mis E, Edgley M, Birnbaum K, Piano F. High-throughput fluorescence-based isolation of live C. elegans larvae. Nature Protocols 2012, 7: 1502-1510. PMID: 22814389, PMCID: PMC5274720, DOI: 10.1038/nprot.2012.084.Peer-Reviewed Original ResearchConceptsGenetic interactionsChemical genetic screenNematode Caenorhabditis elegansFluorescence-activated cell sortingSelection of animalsTermination mutantsCaenorhabditis elegansSorting animalsGenetic screeningChemical screeningGFP expressionCell sortingLarval stageLive animalsHigh-speed sortingMutantsAnimalsFACSIsolatesGenotypesNematodesHomozygotes
2008
The let-7 microRNA target gene, Mlin41/Trim71 is required for mouse embryonic survival and neural tube closure
Maller Schulman BR, Liang X, Stahlhut C, DelConte C, Stefani G, Slack FJ. The let-7 microRNA target gene, Mlin41/Trim71 is required for mouse embryonic survival and neural tube closure. Cell Cycle 2008, 7: 3935-3942. PMID: 19098426, PMCID: PMC2895810, DOI: 10.4161/cc.7.24.7397.Peer-Reviewed Original ResearchConceptsLin-41Neural tube closureTube closureTerminal differentiationPrecocious cell cycle exitNematode Caenorhabditis elegansMore complex organismsCell cycle exitKey developmental eventsMicroRNA target genesNeural tube closure defectsLet-7 microRNACaenorhabditis elegansEpidermal skin cellsEmbryonic lethalityCycle exitComplex organismsTarget genesLet-7Developmental eventsDisease genesMouse mutantsClosure defectsMutantsFunctional role
2003
Adaptation of the nematode Caenorhabditis elegans to extreme osmotic stress
Lamitina ST, Morrison R, Moeckel GW, Strange K. Adaptation of the nematode Caenorhabditis elegans to extreme osmotic stress. American Journal Of Physiology - Cell Physiology 2003, 286: c785-c791. PMID: 14644776, DOI: 10.1152/ajpcell.00381.2003.Peer-Reviewed Original ResearchConceptsExtreme osmotic stressOsmotic stressCell osmoregulationHypertonic stressFunctional genomic analysisNematode Caenorhabditis elegansOrganic osmolyte glycerolPowerful model systemNumerous experimental advantagesCellular osmotic homeostasisCaenorhabditis elegansC. elegansCellular lifeNematode CaenorhabditisOsmolyte glycerolGenomic analysisOsmotic homeostasisGenetic basisOsmotic adaptationTranscriptional expressionOsmotic balanceMolecular understandingAccumulation of glycerolGlycerol accumulationNaCl agar
2000
Mechanisms of programmed cell death in the developing brain
Kuan C, Roth K, Flavell R, Rakic P, Kuan C, Roth K, Flavell R, Rakic P. Mechanisms of programmed cell death in the developing brain. Trends In Neurosciences 2000, 23: 291-297. PMID: 10856938, DOI: 10.1016/s0166-2236(00)01581-2.Peer-Reviewed Original ResearchConceptsCell deathNematode Caenorhabditis elegansEarly embryonic developmentGene-targeting studiesCell death pathwaysVertebrate nervous systemMammalian brain developmentCaenorhabditis elegansEmbryonic developmentGenetic analysisPostmitotic neuronsBrain developmentNeural cell deathAnalogous functionsDistinct rolesProgenitor cellsMammalian brainApoptosisNew insightsImportant mechanismElegansHomologLater stagesNervous systemMechanismProgrammed Cell Death in Mouse Brain Development
Kuan C, Flavell R, Rakic P. Programmed Cell Death in Mouse Brain Development. Results And Problems In Cell Differentiation 2000, 30: 145-162. PMID: 10857188, DOI: 10.1007/978-3-540-48002-0_6.Peer-Reviewed Original ResearchConceptsCell death machineryMouse brain developmentCell deathDeath machineryNematode Caenorhabditis elegansBasic cellular eventsIdeal experimental systemVertebrate nervous systemBrain developmentCaenorhabditis elegansNormal human brain developmentNerve growth factorGenetic pathwaysTrophic theoryRecent geneSpecific genesCellular eventsGenetic studiesNeural developmentHuman brain developmentTargeted disruptionHigher primatesMechanistic understandingEssential roleGenes
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