2024
Inherited Retinal Degenerations and Non-Neovascular Age-Related Macular Degeneration: Progress and Unmet Needs
Duncan J, Bowman A, Laster A, Gelfman C, Birch D, Boye S, Daiger S, del Priore L, Zack D, Handa J, Board T. Inherited Retinal Degenerations and Non-Neovascular Age-Related Macular Degeneration: Progress and Unmet Needs. Translational Vision Science & Technology 2024, 13: 28. PMID: 39688851, PMCID: PMC11654773, DOI: 10.1167/tvst.13.12.28.Peer-Reviewed Original ResearchConceptsAge-related macular degenerationInherited retinal degenerationNon-neovascular age-related macular degenerationRetinal degenerationGeographic atrophyMacular degenerationDevelopment of treatmentsIrreversible vision lossTherapies to slow progressionNon-neovascularVision lossUnmet needsDegenerationSlow progressionPatientsTreatmentProgressionAtrophyTranscranial optogenetic brain modulator for precise bimodal neuromodulation in multiple brain regions
Shin H, Nam M, Lee S, Yang S, Yang E, Jung J, Kim H, Woo J, Cho Y, Yoon Y, Cho I. Transcranial optogenetic brain modulator for precise bimodal neuromodulation in multiple brain regions. Nature Communications 2024, 15: 10423. PMID: 39613730, PMCID: PMC11607408, DOI: 10.1038/s41467-024-54759-0.Peer-Reviewed Original ResearchConceptsBrain regionsBrain modulesModulation of brain functionTranscranial brain stimulationMultiple brain regionsUpconversion particlesSymptoms of Parkinson's diseaseOptical crosstalkStudy of neural circuitsFood competition testBrain dysfunctionExternal light sourceLight sourcesBrain functionStudy of complex behaviorsSpatial resolutionNeural circuitsBrain disordersDevelopment of treatmentsOptogenetic techniquesBrain stimulationNeural populationsBrainParkinson's diseaseNeuromodulation
2023
Developing a definition of immune exclusion in cancer: results of a modified Delphi workshop
Clifton G, Rothenberg M, Ascierto P, Begley G, Cecchini M, Eder J, Ghiringhelli F, Italiano A, Kochetkova M, Li R, Mechta-Grigoriou F, Pai S, Provenzano P, Puré E, Ribas A, Schalper K, Fridman W. Developing a definition of immune exclusion in cancer: results of a modified Delphi workshop. Journal For ImmunoTherapy Of Cancer 2023, 11: e006773. PMID: 37290925, PMCID: PMC10254706, DOI: 10.1136/jitc-2023-006773.Peer-Reviewed Original ResearchConceptsImmune exclusionTumor microenvironmentCheckpoint inhibitorsImmune checkpoint inhibitorsMinority of patientsT cell infiltrationPoor clinical outcomeImmune regulatory pathwaysEffective treatment approachDevelopment of treatmentsVariety of cancersLack of responseCheckpoint therapyImmune profileClinical outcomesClinical benefitPatient outcomesCancer expertsCancer histologyT cellsConsensus definitionTreatment approachesCancer typesRound questionnaireDelphi process
2022
Intestinal microbiome associated with development of grade 3/4 adverse in patients with metastatic renal cell carcinoma (mRCC) treated with nivolumab plus ipilimumab (N/I) and probiotic support: Results from a phase Ib study.
Meza L, Dizman N, Bergerot P, Dorff T, Lyou Y, Frankel P, Llamas M, Hsu J, Zengin Z, Salgia N, Malhotra J, Chawla N, Gillece J, Reining L, Trent J, Takahashi M, Oka K, Higashi S, Highlander S, Pal S. Intestinal microbiome associated with development of grade 3/4 adverse in patients with metastatic renal cell carcinoma (mRCC) treated with nivolumab plus ipilimumab (N/I) and probiotic support: Results from a phase Ib study. Journal Of Clinical Oncology 2022, 40: 374-374. DOI: 10.1200/jco.2022.40.6_suppl.374.Peer-Reviewed Original ResearchMetastatic renal cell carcinomaSetting of mRCCStool microbiome compositionPhase Ib studyWeeks of therapyFirst-line treatmentLung cancer patientsRenal cell carcinomaMicrobiome compositionDevelopment of treatmentsB. thetaiotamicronMedian followMRCC patientsAdverse eventsData cutoffOverall cohortIntervention armLine treatmentCell carcinomaCancer patientsTRAEsStool samplesStool specimensIntestinal microbiomeLarge cohort
2019
Revisiting the Cognitive Model of Depression: The Role of Expectations
Rief W, Joormann J. Revisiting the Cognitive Model of Depression: The Role of Expectations. Clinical Psychology In Europe 2019, 1: 1-19. DOI: 10.32872/cpe.v1i1.32605.Peer-Reviewed Original ResearchRole of expectationsCognitive modelMental disordersChronic depressionExpectation violationPositive eventsDysfunctional expectationsCognitive subsetBehavioral strategiesBasic neuroscienceExpectation changeClinical interventionsFurther implicationsImmunization strategiesTreatment of depressionDepressionConcept of immunizationDepression developmentDevelopment of treatmentsTreatment of patientsTreatment approachesExpectationsCognitionNeuroscienceDisorders
2017
Multiple modality biomarker prediction of cognitive impairment in prospectively followed de novo Parkinson disease
Caspell-Garcia C, Simuni T, Tosun-Turgut D, Wu IW, Zhang Y, Nalls M, Singleton A, Shaw LA, Kang JH, Trojanowski JQ, Siderowf A, Coffey C, Lasch S, Aarsland D, Burn D, Chahine LM, Espay AJ, Foster ED, Hawkins KA, Litvan I, Richard I, Weintraub D, Initiative T. Multiple modality biomarker prediction of cognitive impairment in prospectively followed de novo Parkinson disease. PLOS ONE 2017, 12: e0175674. PMID: 28520803, PMCID: PMC5435130, DOI: 10.1371/journal.pone.0175674.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAmyloid beta-PeptidesBiomarkersBrain-Derived Neurotrophic FactorCatechol O-MethyltransferaseCognitive DysfunctionDiffusion Tensor ImagingDopamine Plasma Membrane Transport ProteinsFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedParkinson DiseasePolymorphism, Single Nucleotidetau ProteinsTomography, Emission-Computed, Single-PhotonConceptsParkinson's diseaseCognitive impairmentDe novo Parkinson's diseaseDopamine transporter single-photon emissionLongitudinal mixed-effects modelsNovo Parkinson's diseaseYears of diseaseIdiopathic Parkinson's diseaseMovement Disorders CenterSingle nucleotide polymorphismsStructural magnetic resonance imagingClinical trial designLongitudinal structural MRIMagnetic resonance imagingSingle photon emissionDevelopment of treatmentsDiffusion tensor imagingBiomarker predictorsPlaque pathologyAmyloid pathologyDopamine deficiencyDopaminergic deficitUnivariate analysisBiomarker changesDisorders Center
2016
Roscoe Owen Brady, MD: Remembrances of co-investigators and colleagues
Desnick RJ, Barton NW, Furbish S, Grabowski GA, Karlsson S, Kolodny EH, Medin JA, Murray GJ, Mistry PK, Patterson MC, Schiffmann R, Weinreb NJ. Roscoe Owen Brady, MD: Remembrances of co-investigators and colleagues. Molecular Genetics And Metabolism 2016, 120: 1-7. PMID: 27866832, DOI: 10.1016/j.ymgme.2016.10.010.Peer-Reviewed Original Research
2014
Neuroimaging of Eating Disorders, Substance Use Disorders, and Addictions: Overlapping and Unique Systems
Gearhardt A, Boswell R, Potenza M. Neuroimaging of Eating Disorders, Substance Use Disorders, and Addictions: Overlapping and Unique Systems. 2014, 71-89. DOI: 10.1007/978-3-642-45378-6_4.Peer-Reviewed Original ResearchAddictive disordersMemory/learningDomains of impairmentBinge-eating disorderExecutive controlNeural commonalitiesEmotional reactivityInteroceptive awarenessSubstance use disordersEating DisordersBulimia nervosaDimensional approachAnorexia nervosaUse disordersFuture researchDevelopment of treatmentsNervosaDisordersRewardFunctioningMotivationAddictionConceptualizationLearningImpairment
2009
Noradrenergic and serotonergic mechanisms in the neurobiology of posttraumatic stress disorder and resilience
Krystal JH, Neumeister A. Noradrenergic and serotonergic mechanisms in the neurobiology of posttraumatic stress disorder and resilience. Brain Research 2009, 1293: 13-23. PMID: 19332037, PMCID: PMC2761677, DOI: 10.1016/j.brainres.2009.03.044.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderStress disorderOrdinary stressful life eventsEtiology of PTSDNeurobiology of PTSDSymptoms of PTSDImpact of traumaStressful life eventsTraumatic eventsNeurobiological systemsLife eventsTreatment developmentSerotonergic mechanismsNeurobiologyUse of antidepressantsDevelopment of treatmentsBasic researchResilienceMonoaminergic mechanismsAvailable treatmentsRelevant findingsHyperarousalResearchDisordersPsychopathology
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