2025
Disrupted Resting‐State Functional Connectivity in the Social Visual Pathway in Children With Autism Spectrum Disorder
Li C, Park H, Awasthi J, Rolison M, Li M, Scheinost D, Chawarska K, Hampson M. Disrupted Resting‐State Functional Connectivity in the Social Visual Pathway in Children With Autism Spectrum Disorder. Autism Research 2025, 18: 1024-1036. PMID: 40183221, DOI: 10.1002/aur.70037.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderSuperior temporal sulcusResting-state functional connectivityFunctional connectivitySpectrum disorderMiddle superior temporal sulcusAutism Brain Imaging Data Exchange (ABIDEVisual motion areasVisual pathwaySignificant hypoconnectivityTD childrenTD groupTemporal sulcusRight hemisphereDorsal pathwaySocial difficultiesSocial symptomsSocial informationAutismDisordersChildrenMotion areaHypoconnectivityAnterior portionTD
2024
Networks extracted from nonlinear fMRI connectivity exhibit unique spatial variation and enhanced sensitivity to differences between individuals with schizophrenia and controls
Kinsey S, Kazimierczak K, Camazón P, Chen J, Adali T, Kochunov P, Adhikari B, Ford J, van Erp T, Dhamala M, Calhoun V, Iraji A. Networks extracted from nonlinear fMRI connectivity exhibit unique spatial variation and enhanced sensitivity to differences between individuals with schizophrenia and controls. Nature Mental Health 2024, 2: 1464-1475. PMID: 39650801, PMCID: PMC11621020, DOI: 10.1038/s44220-024-00341-y.Peer-Reviewed Original ResearchSelf-referential cognitionFunctional magnetic resonance imaging connectivityFunctional brain connectivityCingulo-opercularDefault-modeSchizophrenia diagnosisExecutive regionsFMRI connectivityFunctional connectivityConnectivity analysisSchizophreniaSensitive to differencesBrain connectivityFunctional connectivity structureWidespread alterationsImaging connectivityIndependent component analysisBrain phenomenaNetwork integrationHypoconnectivityPsychosisCognitionCore regionNonlinear networksCase-control dataset
2022
Hypoconnectivity between anterior insula and amygdala associates with future vulnerabilities in social development in a neurodiverse sample of neonates
Scheinost D, Chang J, Lacadie C, Brennan-Wydra E, Foster R, Boxberger A, Macari S, Vernetti A, Constable RT, Ment LR, Chawarska K. Hypoconnectivity between anterior insula and amygdala associates with future vulnerabilities in social development in a neurodiverse sample of neonates. Scientific Reports 2022, 12: 16230. PMID: 36171268, PMCID: PMC9517994, DOI: 10.1038/s41598-022-20617-6.Peer-Reviewed Original ResearchConceptsFirst Year InventoryAnterior insulaFunctional connectivityMaternal mental health factorsLeft anterior insulaState functional connectivityMental health factorsSubsample of participantsPostmenstrual ageSalience networkFamily historySocial domainsNeural circuitryAutismSocial behaviorBrain imagingHigher likelihoodInsulaSocial developmentHypoconnectivityExploratory analysisThird trimesterFuture onsetHealth factorsRisk score
2020
Early life stress causes sex-specific changes in adult fronto-limbic connectivity that differentially drive learning
White JD, Arefin TM, Pugliese A, Lee CH, Gassen J, Zhang J, Kaffman A. Early life stress causes sex-specific changes in adult fronto-limbic connectivity that differentially drive learning. ELife 2020, 9: e58301. PMID: 33259286, PMCID: PMC7725504, DOI: 10.7554/elife.58301.Peer-Reviewed Original ResearchConceptsEarly life stressSex-specific changesContextual freezing behaviorFronto-limbic connectivityLife stressHigh-resolution diffusion magnetic resonance imagingSex-specific mechanismsMagnetic resonance imagingNeuroanatomical alterationsPostnatal stressDiffusion magnetic resonance imagingMouse modelFronto-limbicResonance imagingModerate responseMalesTranslational workFemalesRodentsFreezing behaviorHuman imagingImagingHypoconnectivityInjury
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