2019
Chronic maternal cortisol excess during late gestation leads to metabolic alterations in the newborn heart
Walejko J, Antolic A, Koelmel J, Garrett T, Edison A, Keller-Wood M. Chronic maternal cortisol excess during late gestation leads to metabolic alterations in the newborn heart. AJP Endocrinology And Metabolism 2019, 316: e546-e556. PMID: 30620638, PMCID: PMC6459297, DOI: 10.1152/ajpendo.00386.2018.Peer-Reviewed Original ResearchConceptsNewborn heartLate gestationCortisol altersMaternal cortisolCardiac arrhythmiasFetal cardiac arrhythmiasMaternal serum specimensCortisol excessFetal exposureMaternal serumFetal metabolismCardiac metabolitesAbnormal elevationExcess cortisolLipid profileChronic increaseFetal serumGestation leadMetabolic alterationsSerum specimensHeart specimensFetal heartLipid metabolitesGlycerophospholipid metabolismCortisol
2018
Multiomics approach reveals metabolic changes in the heart at birth
Walejko J, Koelmel J, Garrett T, Edison A, Keller-Wood M. Multiomics approach reveals metabolic changes in the heart at birth. AJP Endocrinology And Metabolism 2018, 315: e1212-e1223. PMID: 30300011, PMCID: PMC6336953, DOI: 10.1152/ajpendo.00297.2018.Peer-Reviewed Original ResearchConceptsEnrichment analysisOverrepresentation enrichment analysisNewborn heartFetal heartTranscriptomic approachTranscriptomic levelT-testMetabolic changesFatty acidsMetabolomic levelsGlycerophospholipid metabolic pathwayTranscriptomic findingsMultiomics approachPropanoate metabolismTreatment of neonatesOxidative phosphorylationDifferential expressionDay of birthSingle-sample geneMetabolic pathwaysGreater abundanceStudent's t-testHeart failureRight ventricleIntraventricular septum
2017
Pumpless Extracorporeal Support of the Preterm Infant: Bridging Fetal and Postnatal Physiology
Partridge E, Davey M, Hornick M, Flake A. Pumpless Extracorporeal Support of the Preterm Infant: Bridging Fetal and Postnatal Physiology. NeoReviews 2017, 18: e277-e282. DOI: 10.1542/neo.18-5-e277.Peer-Reviewed Original ResearchPreterm infantsExtracorporeal supportExtremely preterm infantsExtracorporeal membrane oxygenation (ECMO) technologyStable hemodynamicsPreterm birthClinical outcomesUmbilical circulationChildhood morbidityFetal perfusionNeonatal careNeonatal mortalityFetal lambsFetal survivalIntrauterine environmentClinical challengeNeonatal developmentFetal heartInfantsUnsolved clinical challengeExtracorporeal systemPhysiologic homeostasisMajor causePhysiologic systemsOrgan maturation
2013
ISUOG Practice Guidelines (updated): sonographic screening examination of the fetal heart
International Society of Ultrasound in Obstetrics and Gynecology, Carvalho J, Allan L, Chaoui R, Copel J, DeVore G, Hecher K, Lee W, Munoz H, Paladini D, Tutschek B, Yagel S. ISUOG Practice Guidelines (updated): sonographic screening examination of the fetal heart. Ultrasound In Obstetrics And Gynecology 2013, 41: 348-359. PMID: 23460196, DOI: 10.1002/uog.12403.Commentaries, Editorials and Letters
1996
Fetal cardiac implications of maternal systemic diseases
Martinez E, Sian A, Kleinman C, Copel J. Fetal cardiac implications of maternal systemic diseases. Progress In Pediatric Cardiology 1996, 5: 91-101. DOI: 10.1016/1058-9813(95)00154-9.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMaternal systemic diseaseConnective tissue diseaseSystemic diseaseCardiac implicationsTissue diseaseCardiac anomaliesMaternal connective tissue diseaseCongenital complete heart blockNeonatal lupus syndromeTransient cutaneous lesionsComplete heart blockFetal congenital anomaliesFetal cardiac anomaliesAutosomal recessive transmissionLupus syndromePerinatal morbidityDiabetes mellitusHeart blockCutaneous lesionsTeratogenic riskCongenital anomaliesFetal heartToxic insultsWeek 3Recessive transmission
1992
Fetal Cardiovascular Physiology and Therapy
Kleinman C, Copel J. Fetal Cardiovascular Physiology and Therapy. Fetal Diagnosis And Therapy 1992, 7: 147-157. PMID: 1503650, DOI: 10.1159/000263663.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsFetal cardiovascular physiologyFetal lamb modelHuman fetal heartSurgical interventionFetal heartLamb modelCardiovascular physiologyFetal cardiovascular malformationsFetal ductus arteriosusFetal cardiovascular systemVentricular filling characteristicsFetal cardiac developmentSystolic reserveVentricular afterloadDuctus arteriosusThird trimesterForamen ovaleNeonatal periodVentricular hypoplasiaFetal lambsShunt flowPrenatal interventionTimely therapyCardiovascular malformationsHuman fetuses
1991
Foramen ovale size in the normal and abnormal human fetal heart: an indicator of transatrial flow physiology
Feit L, Copel J, Kleinman C. Foramen ovale size in the normal and abnormal human fetal heart: an indicator of transatrial flow physiology. Ultrasound In Obstetrics And Gynecology 1991, 1: 313-319. PMID: 12797035, DOI: 10.1046/j.1469-0705.1991.01050313.x.Peer-Reviewed Original ResearchHeart obstructive lesionsLeft heart obstructive lesionsObstructive lesionsColor Doppler studyDoppler studiesForamen ovaleColor flow Doppler studiesNormal cardiac anatomyCongenital heart diseaseRight ventricular developmentNormal flow patternsHuman fetal heartWeeks' gestationVentricular sizeDoppler interrogationFetal echocardiographyHeart diseaseAtrial septumHelpful adjunctNormal fetusesHuman fetusesFetal heartLesionsFetusesCardiac anatomy
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