2020
Neural Stem Cells Direct Axon Guidance via Their Radial Fiber Scaffold
Kaur N, Han W, Li Z, Madrigal MP, Shim S, Pochareddy S, Gulden FO, Li M, Xu X, Xing X, Takeo Y, Li Z, Lu K, Imamura Kawasawa Y, Ballester-Lurbe B, Moreno-Bravo JA, Chédotal A, Terrado J, Pérez-Roger I, Koleske AJ, Sestan N. Neural Stem Cells Direct Axon Guidance via Their Radial Fiber Scaffold. Neuron 2020, 107: 1197-1211.e9. PMID: 32707082, PMCID: PMC7529949, DOI: 10.1016/j.neuron.2020.06.035.Peer-Reviewed Original ResearchConceptsNeural stem cellsDendritic spine formationNeural circuit formationRadial glia-like neural stem cellsMedial ganglionic eminenceRadial fibersAxon guidanceStem cellsCorticospinal neuronsGlobus pallidusMacroglial cellsGanglionic eminenceCircuit formationVentricular zoneSpine formationRnd3/RhoENeuronsMidline crossingExpression of Rnd3Rho GTPaseCellsExpressionUnexpected roleAtypical Rho GTPaseRnd3
2019
Btbd3 expression regulates compulsive-like and exploratory behaviors in mice
Thompson SL, Welch AC, Ho EV, Bessa JM, Portugal-Nunes C, Morais M, Young JW, Knowles JA, Dulawa SC. Btbd3 expression regulates compulsive-like and exploratory behaviors in mice. Translational Psychiatry 2019, 9: 222. PMID: 31501410, PMCID: PMC6733800, DOI: 10.1038/s41398-019-0558-7.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderKnockout miceCompulsive-like behaviorLimbic cortico-striatoExploratory behaviorThalamo-cortical circuitsMarble-burying testPrimary sensory cortexNeural circuit formationDendritic morphologyImpaired goal-directed behaviorAnterior cingulate cortexGoal-directed behaviorChronic treatmentSpine densityCortico-striatoMediodorsal thalamusDendritic pruningSensory cortexNeonatal developmentAnterior cingulateCingulate cortexCircuit formationPotential risk genesMice
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