2024
Multi-ancestry meta-analysis of tobacco use disorder identifies 461 potential risk genes and reveals associations with multiple health outcomes
Toikumo S, Jennings M, Pham B, Lee H, Mallard T, Bianchi S, Meredith J, Vilar-Ribó L, Xu H, Hatoum A, Johnson E, Pazdernik V, Jinwala Z, Pakala S, Leger B, Niarchou M, Ehinmowo M, Jenkins G, Batzler A, Pendegraft R, Palmer A, Zhou H, Biernacka J, Coombes B, Gelernter J, Xu K, Hancock D, Cox N, Smoller J, Davis L, Justice A, Kranzler H, Kember R, Sanchez-Roige S. Multi-ancestry meta-analysis of tobacco use disorder identifies 461 potential risk genes and reveals associations with multiple health outcomes. Nature Human Behaviour 2024, 8: 1177-1193. PMID: 38632388, PMCID: PMC11199106, DOI: 10.1038/s41562-024-01851-6.Peer-Reviewed Original ResearchConceptsTobacco use disorderPotential risk genesMulti-ancestry meta-analysisMultiple health outcomesElectronic health recordsSource of phenotypic informationGenome-wide association studiesUse disorderAscertainment cohortHealth outcomesHealth recordsPrevalent substance use disordersRisk genesIndependent risk lociUK BiobankSubstance use disordersSmoking behaviorMedical outcomesFunctional genomics toolsPsychiatric traitsAssociation studiesRisk lociRisk variantsHeart diseaseGenomic tools
2023
MULTI-ANCESTRY META-ANALYSIS OF TOBACCO USE DISORDERS PRIORITIZES NOVEL CANDIDATE RISK GENES AND REVEALS ASSOCIATIONS WITH NUMEROUS HEALTH OUTCOMES
Sanchez-Roige S, Toikumo S, Jennings M, Pham B, Lee H, Mallard T, Bianchi S, Meredith J, Smoller J, Davis L, Justice A, Kranzler H, Kember R, Sanchez-Roige S. MULTI-ANCESTRY META-ANALYSIS OF TOBACCO USE DISORDERS PRIORITIZES NOVEL CANDIDATE RISK GENES AND REVEALS ASSOCIATIONS WITH NUMEROUS HEALTH OUTCOMES. European Neuropsychopharmacology 2023, 75: s8-s9. DOI: 10.1016/j.euroneuro.2023.08.024.Peer-Reviewed Original ResearchTobacco use disorderUse disordersPrevalent substance use disordersSubstance use disordersRisk genesNumerous health outcomesHIV infectionHeart diseaseSmoking behaviorMedical outcomesGenome-wide association studiesNicotine consumptionHealth outcomesCandidate risk genesPotential risk genesGenetic factorsIndependent risk lociDisordersRisk variantsNovel candidate risk genesRisk lociOutcomesMajority of variantsFunctional genomics toolsPsychiatric traits
2019
Btbd3 expression regulates compulsive-like and exploratory behaviors in mice
Thompson SL, Welch AC, Ho EV, Bessa JM, Portugal-Nunes C, Morais M, Young JW, Knowles JA, Dulawa SC. Btbd3 expression regulates compulsive-like and exploratory behaviors in mice. Translational Psychiatry 2019, 9: 222. PMID: 31501410, PMCID: PMC6733800, DOI: 10.1038/s41398-019-0558-7.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderKnockout miceCompulsive-like behaviorLimbic cortico-striatoExploratory behaviorThalamo-cortical circuitsMarble-burying testPrimary sensory cortexNeural circuit formationDendritic morphologyImpaired goal-directed behaviorAnterior cingulate cortexGoal-directed behaviorChronic treatmentSpine densityCortico-striatoMediodorsal thalamusDendritic pruningSensory cortexNeonatal developmentAnterior cingulateCingulate cortexCircuit formationPotential risk genesMice
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