2024
High p16INK4A expression in glioblastoma is associated with senescence phenotype and better prognosis
Park S, Roh T, Tanaka Y, Kim Y, Park S, Kim T, Eom S, Park T, Park I, Kim S, Kim J. High p16INK4A expression in glioblastoma is associated with senescence phenotype and better prognosis. Neoplasia 2024, 60: 101116. PMID: 39724755, PMCID: PMC11729681, DOI: 10.1016/j.neo.2024.101116.Peer-Reviewed Original ResearchConceptsP16<sup>INK4a</sup> expressionImmune cell infiltrationTumor cellsCell infiltrationImmunologically active tumor microenvironmentInfiltration of T cellsActive tumor microenvironmentTERT promoter mutationsExtended overall survivalIsocitrate dehydrogenase (IDH)-wildtypeSecretion of chemokinesSenescent phenotypeMalignant brain tumorsIn vitro studiesEGFR amplificationOverall survivalTumor microenvironmentCDKN2A/2B deletionT cellsPrognostic markerImprove prognosisP16INK4A expressionPromoter mutationsTumorBrain tumors
2016
Myelin phagocytosis by astrocytes after myelin damage promotes lesion pathology
Ponath G, Ramanan S, Mubarak M, Housley W, Lee S, Sahinkaya FR, Vortmeyer A, Raine CS, Pitt D. Myelin phagocytosis by astrocytes after myelin damage promotes lesion pathology. Brain 2016, 140: 399-413. PMID: 28007993, PMCID: PMC5841057, DOI: 10.1093/brain/aww298.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAnimalsAnimals, NewbornAstrocytesCell ProliferationCells, CulturedChild, PreschoolCultureCytokinesDemyelinating Autoimmune Diseases, CNSEndocytosisFemaleHumansHydrazonesMacrophagesMaleMiddle AgedMyelin SheathPhagocytosisRatsRats, Sprague-DawleyStrokeTime FactorsTransforming Growth Factor betaConceptsMyelin injuryMyelin phagocytosisMyelin debrisMultiple sclerosis lesionsMultiple sclerosisLesion pathologySclerosis lesionsAcute multiple sclerosis lesionsCentral nervous system pathologyProgressive multifocal leukoencephalopathyNervous system pathologySecretion of chemokinesNF-κB activationElevated chemokine expressionHypertrophic astrocytesMost astrocytesMyelin uptakeMultifocal leukoencephalopathyFirst-line responseAcute lesionsMyelin damageReactive astrocytesChemokine expressionAstroglial responseImmune cells
2005
A Role for TLRs in the Regulation of Immune Cell Migration by First Trimester Trophoblast Cells
Abrahams VM, Visintin I, Aldo PB, Guller S, Romero R, Mor G. A Role for TLRs in the Regulation of Immune Cell Migration by First Trimester Trophoblast Cells. The Journal Of Immunology 2005, 175: 8096-8104. PMID: 16339547, DOI: 10.4049/jimmunol.175.12.8096.Peer-Reviewed Original ResearchConceptsFirst trimester trophoblast cellsInnate immune cellsMaternal-fetal interfaceTrophoblast cellsIntrauterine infectionPregnancy complicationsNormal pregnancyImmune cellsImmune responseImmune systemHuman first trimester trophoblast cellsGrowth-related oncogene alphaCertain pregnancy complicationsElevated leukocyte infiltrationMaternal immune systemGrowth-related oncogeneTLR-3 stimulationImmune cell migrationSecretion of chemokinesInnate immune systemElevated monocytesPaternal AgsPreterm laborNK cellsTLR-3
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