2025
FTO regulates ELK3-mediated metabolic rewiring and represents a unique therapeutic target in T cell leukemia
Huang H, Li X, Luo J, Gao C, Yang M, Xu J, Xie T, Chen Z, Wang D, Wang Y, Li H, Huang J, Liu Y, Zhang H, Ntziachristos P, Zhao Y, Qing G, Liu H. FTO regulates ELK3-mediated metabolic rewiring and represents a unique therapeutic target in T cell leukemia. Science Advances 2025, 11: eadq3052. PMID: 40435251, PMCID: PMC12118595, DOI: 10.1126/sciadv.adq3052.Peer-Reviewed Original ResearchConceptsT-cell leukemiaT-ALLT-cell acute lymphoblastic leukemiaAcute lymphoblastic leukemiaExpression of glycolytic genesDevelopment of potential therapeutic strategiesPotential therapeutic strategyAntileukemia efficacyLymphoblastic leukemiaLeukemia initiationLymphoid leukemiaTherapeutic strategiesGlycolytic genesPharmacological inhibitionMetabolic rewiringLeukemiaDemethylase FTOHuman cancersN6-methyladenosineMRNA stabilityTherapeutic targetCancerMechanistic analysisMRNAModel system
2024
HTLV-1 induces an inflammatory CD4+CD8+ T cell population in HTLV-1–associated myelopathy
Maher A, Aristodemou A, Giang N, Tanaka Y, Bangham C, Taylor G, Dominguez-Villar M. HTLV-1 induces an inflammatory CD4+CD8+ T cell population in HTLV-1–associated myelopathy. JCI Insight 2024, 9: e173738. PMID: 38193535, PMCID: PMC10906466, DOI: 10.1172/jci.insight.173738.Peer-Reviewed Original ResearchConceptsHTLV-1-associated myelopathyDP T cellsT cellsHTLV-1Double-positive T cellsAdult T-cell leukemiaT cell populationsT-cell tropismHTLV-1 infectionHuman T-cell leukemia virus type 1Virus type 1T-cell leukemiaCXCR3 expressionPreferential CD4Asymptomatic infectionCNS pathologyIL-6Asymptomatic carriersInflammatory diseasesCytotoxic phenotypeCell leukemiaCell tropismType 1CD4Cell populations
2022
HIV-1 and HTLV-1 Transmission Modes: Mechanisms and Importance for Virus Spread
Kalinichenko S, Komkov D, Mazurov D. HIV-1 and HTLV-1 Transmission Modes: Mechanisms and Importance for Virus Spread. Viruses 2022, 14: 152. PMID: 35062355, PMCID: PMC8779814, DOI: 10.3390/v14010152.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusAdult T-cell leukemiaHTLV-1HIV-1Development of acquired immunodeficiency syndromeMode of transmissionInfected CD4+ T lymphocytesHuman T-cell lymphotropic virus type 1Biology of HIV-1Human immunodeficiency virus replicationCD4+ T lymphocytesHTLV-1-associated myelopathyNeurological autoimmune disordersT-cell leukemiaVirus type 1Tropical spastic paraparesisCD4 lymphocytesImmunodeficiency syndromeImmunodeficiency virusBlood transfusionT lymphocytesAutoimmune disordersInfected patientsTransformed lymphocytesSpastic paraparesis
2021
Adverse cardiovascular events in patients treated with mogamulizumab
Kwan J, Henry M, Cook K, Higgins A, Cuomo J, Foss F, Baldassarre L. Adverse cardiovascular events in patients treated with mogamulizumab. American Heart Journal Plus Cardiology Research And Practice 2021, 9: 100049. PMID: 38559371, PMCID: PMC10978139, DOI: 10.1016/j.ahjo.2021.100049.Peer-Reviewed Original ResearchAdverse cardiovascular eventsMogamulizumab therapyCardiovascular eventsHeart failureAdverse outcomesNon-cardiovascular eventsWorld Health Organization databaseFatal adverse outcomesT-cell leukemiaACE occurrenceMogamulizumab treatmentNew hypertensionAdverse eventsCardiac deathVentricular arrhythmiasFatal outcomeUnique patientsCardiovascular toxicityMyocardial infarctionImportant treatmentHigh mortalityPatientsMogamulizumabTherapyOrganization database
2020
Weekly Dosing Schedule of Brentuximab Vedotin in Mycosis Fungoides/Sezary Syndrome and Aggressive T Cell Lymphomas
Lee M, Schiffer M, Isufi I, Huntington S, Xu M, Seropian S, Gowda L, Kothari S, Girardi M, Foss F. Weekly Dosing Schedule of Brentuximab Vedotin in Mycosis Fungoides/Sezary Syndrome and Aggressive T Cell Lymphomas. Blood 2020, 136: 21-22. DOI: 10.1182/blood-2020-139790.Peer-Reviewed Original ResearchT-cell lymphomaAggressive T-cell lymphomaWeekly dosing scheduleMycosis fungoides/Sezary syndromeMF/SSWeekly dosingCell lymphomaDosing schedulesBrentuximab vedotinSezary syndromeGamma-delta T-cell lymphomaWeekly scheduleNK-T cell lymphomaAngioimmunoblastic T-cell lymphomaPeripheral T-cell lymphomaAnaplastic large cell lymphomaCancer response rateIncidence of neuropathyWeekly x 3Prospective clinical trialsStem cell transplantAdult T-cell leukemiaLarge cell lymphomaT-cell leukemiaDose weekly
2018
Stage-specific roles for Zmiz1 in Notch-dependent steps of early T-cell development
Wang Q, Yan R, Pinnell N, McCarter A, Oh Y, Liu Y, Sha C, Garber N, Chen Y, Wu Q, Ku C, Tran I, Serna Alarcon A, Kuick R, Engel J, Maillard I, Cierpicki T, Chiang M. Stage-specific roles for Zmiz1 in Notch-dependent steps of early T-cell development. Blood 2018, 132: 1279-1292. PMID: 30076146, PMCID: PMC6148450, DOI: 10.1182/blood-2018-02-835850.Peer-Reviewed Original ResearchConceptsDN-DP transitionDouble-negative (Pre-T cellsCD4<sup>-</sup>CD8<sup>-</sup> double-negativeStage-specific rolesTetratricopeptide repeatDouble-positive (DP) stageEarly T cell developmentT cell developmentT-cell leukemiaLoss of Notch1T lineage progenitorsElevated to higher levelsLeukemic proliferationT cellsT-lineageLeukemic cellsNotch1 transcriptional complexTPR proteinsBind Notch1Thymocyte proliferationActive Notch1Myc inductionTranscription complexNotch1 signaling
2012
107 Multi-level Gene Expression Regulation Effects of the NAMPT Inhibitor FK866 in a Model of Acute T Cell Leukemia
Zucal C, D'Agostino V, Tebaldi T, Sociali G, Bruzzone S, Quattrone A, Nencioni A, Provenzani A. 107 Multi-level Gene Expression Regulation Effects of the NAMPT Inhibitor FK866 in a Model of Acute T Cell Leukemia. European Journal Of Cancer 2012, 48: 33-34. DOI: 10.1016/s0959-8049(12)71905-6.Peer-Reviewed Original Research
2008
Obesity Accelerates T-Cell Leukemia in a Spontaneous Mouse Model.
Yun J, Klemm L, Behan J, Müschen M, Mittelman S. Obesity Accelerates T-Cell Leukemia in a Spontaneous Mouse Model. Blood 2008, 112: 1909. DOI: 10.1182/blood.v112.11.1909.1909.Peer-Reviewed Original ResearchAKR/J miceSpontaneous T cell leukemiaT-cell leukemiaT cell maturationDiet-induced obesityJ miceOnset of leukemiaLeukemic miceDiet groupMouse modelControl dietEffect of obesityCD4/CD8Non-obese counterpartsT cell subgroupsHigh-fat dietSpontaneous mouse modelMonths of ageT cell differentiationWeeks of ageTypes of cancerCD4/ CD8Clinical illnessThymus weightLifestyle parameters
2006
Efficacy of low dose clofarabine in refractory precursor T- acute lymphoblastic leukemia.
Choi J, Foss F. Efficacy of low dose clofarabine in refractory precursor T- acute lymphoblastic leukemia. The Yale Journal Of Biology And Medicine 2006, 79: 169-72. PMID: 17940627, PMCID: PMC1994805.Peer-Reviewed Original ResearchMeSH KeywordsAdenine NucleotidesAdultArabinonucleosidesBone Marrow NeoplasmsClinical Trials as TopicClofarabineDrug Administration ScheduleDrug Resistance, NeoplasmHumansImmunophenotypingLeukemia-Lymphoma, Adult T-CellMaleRecurrenceSkin NeoplasmsStem Cell TransplantationTransplantation, HomologousTreatment OutcomeConceptsLow dose clofarabineLymphoblastic leukemiaAllogeneic stem cell transplantationSignificant clinical activityStem cell transplantationNear complete responseAcute lymphoblastic leukemiaPediatric B-ALLT-cell leukemiaAllogeneic transplantsComplete responsePoor prognosisCell transplantationB-ALLPrecursor TClinical activityNew agentsNovel nucleoside analogueClofarabinePatientsLeukemiaNucleoside analoguesSignificant activityRemissionTransplantation
2005
Small Nuclear RNAs Encoded by Herpesvirus saimiri Upregulate the Expression of Genes Linked to T Cell Activation in Virally Transformed T Cells
Cook HL, Lytle JR, Mischo HE, Li MJ, Rossi JJ, Silva DP, Desrosiers RC, Steitz JA. Small Nuclear RNAs Encoded by Herpesvirus saimiri Upregulate the Expression of Genes Linked to T Cell Activation in Virally Transformed T Cells. Current Biology 2005, 15: 974-979. PMID: 15916956, DOI: 10.1016/j.cub.2005.04.034.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, CDAntigens, Differentiation, T-LymphocyteAntigens, NeoplasmBase PairingBlotting, NorthernBlotting, WesternCallithrixCD52 AntigenCell Line, TumorFlow CytometryGenetic VectorsGenome, ViralGlycoproteinsHerpesvirus 2, SaimiriineLentivirusLymphocyte ActivationMembrane ProteinsMicroarray AnalysisOncogene Proteins, ViralReceptors, Antigen, T-CellReceptors, ImmunologicRNA, Small NuclearT-LymphocytesTransduction, GeneticUp-RegulationConceptsSmall nuclear RNAHSURs 1Herpesvirus saimiriNuclear RNAExpression of genesAggressive T-cell leukemiaMarmoset T cellsHSUR 1U RNAAbundant viral transcriptCell activationT cellsHost mRNAsUnexpected roleIntracellular proteinsNorthern analysisSm classHost targetsViral transcriptsT cell activationNew World primatesRNAT-cell receptor betaT-cell leukemiaGamma chain
2003
Denileukin Diftitox and Hyper-CVAD in the Treatment Human T-Cell Lymphotropic Virus 1–Associated Adult T-Cell Leukemia/Lymphoma
DiVenuti G, Nawgiri R, Foss F. Denileukin Diftitox and Hyper-CVAD in the Treatment Human T-Cell Lymphotropic Virus 1–Associated Adult T-Cell Leukemia/Lymphoma. Clinical Lymphoma Myeloma & Leukemia 2003, 4: 176-178. PMID: 14715100, DOI: 10.3816/clm.2003.n.027.Peer-Reviewed Original ResearchConceptsAdult T-cell leukemia/lymphomaT-cell leukemia/lymphomaDenileukin diftitoxLeukemia/lymphomaClinical remissionHuman T-cell lymphotropic virus-1Human T-cell lymphotropic virusCell leukemia/lymphomaBone marrow myelofibrosisComplete clinical remissionBone marrow biopsyLymphotropic virus-1Acute T-cell leukemiaNormal hematopoiesisT-cell leukemiaLeukemic T cellsExtensive myelofibrosisHyper-CVADInitial therapyMaintenance therapyClinical improvementClinical manifestationsMarrow biopsyDisease progressionT cells
2002
Immunomodulatory effects of RXR rexinoids: modulation of high-affinity IL-2R expression enhances susceptibility to denileukin diftitox
Gorgun G, Foss F. Immunomodulatory effects of RXR rexinoids: modulation of high-affinity IL-2R expression enhances susceptibility to denileukin diftitox. Blood 2002, 100: 1399-1403. PMID: 12149223, DOI: 10.1182/blood-2002-01-0300.Peer-Reviewed Original ResearchMeSH KeywordsAdjuvants, ImmunologicAlitretinoinAntineoplastic AgentsB-LymphocytesBexaroteneDiphtheria ToxinGene Expression RegulationHumansInterleukin-2Leukemia-Lymphoma, Adult T-CellLeukemia, Lymphocytic, Chronic, B-CellPrecursor B-Cell Lymphoblastic Leukemia-LymphomaReceptors, Interleukin-2Receptors, Retinoic AcidRecombinant Fusion ProteinsRetinoid X ReceptorsRetinoidsT-LymphocytesTetrahydronaphthalenesTranscription FactorsTretinoinTumor Cells, CulturedConceptsRetinoic acid receptorsImmunomodulatory effectsIL-2RHigh affinity IL-2R expressionCutaneous T-cell lymphomaHigh affinity IL-2R.Interleukin-2 receptor expressionIL-2R expressionT-cell lymphomaB cell leukemia cellsB-cell leukemiaT-cell leukemiaMechanism of actionAutoimmune diseasesHematologic malignanciesClinical activityReceptor expressionLymphoid malignanciesIL-2R.Retinoid X receptor (RXR) familyP75 subunitAcid receptorsRexinoid receptorsLeukemia cellsRexinoids
2001
Separation of Notch1 Promoted Lineage Commitment and Expansion/Transformation in Developing T Cells
Allman D, Karnell F, Punt J, Bakkour S, Xu L, Myung P, Koretzky G, Pui J, Aster J, Pear W. Separation of Notch1 Promoted Lineage Commitment and Expansion/Transformation in Developing T Cells. Journal Of Experimental Medicine 2001, 194: 99-106. PMID: 11435476, PMCID: PMC2193437, DOI: 10.1084/jem.194.1.99.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBone MarrowCell LineageDNA-Binding ProteinsHematopoietic Stem CellsHyaluronan ReceptorsLeukemia, T-CellMembrane ProteinsMiceMice, TransgenicReceptor, Notch1Receptors, Antigen, T-Cell, alpha-betaReceptors, Cell SurfaceReceptors, Interleukin-2Signal TransductionT-LymphocytesThymus GlandTranscription FactorsConceptsT lineage commitmentT cell developmentHematopoietic stem cellsLineage commitmentCell developmentSrc homology 2 domainPre-T cell receptorBone marrowT cell-specific signalsBM transferT cellsCell-specific signalsMultipotent progenitor cellsDouble-positive T cellsTCR-beta transgeneLeukocyte proteinBM cell populationsFunction of Notch1T-cell leukemiaLater time pointsCD3 epsilonActive Notch1Beta transgeneBM cellsCell leukemiaSex‐specific mortality from adult T‐cell leukemia among carriers of human T‐lymphotropic virus type I
Hisada M, Okayama A, Spiegelman D, Mueller N, Stuver S. Sex‐specific mortality from adult T‐cell leukemia among carriers of human T‐lymphotropic virus type I. International Journal Of Cancer 2001, 91: 497-499. PMID: 11251972, DOI: 10.1002/1097-0215(20010215)91:4<497::aid-ijc1044>3.0.co;2-a.Peer-Reviewed Original ResearchConceptsAdult T-cell leukemiaHTLV-I carriersHuman T-lymphotropic virus type IRelative riskVirus type IT-cell leukemiaIncidence of ATLMiyazaki Cohort StudyUnadjusted relative riskAdjusted relative riskType IPerinatal infectionEarlier average ageCohort studyMale predominanceRisk factorsAverage ageInfectionMortalityNumber of personsLeukemiaEarly ageMalesFemalesSex-specific mortality
1998
Risk factors for adult T-cell leukemia among carriers of human T-lymphotropic virus type I.
Hisada M, Okayama A, Shioiri S, Spiegelman D, Stuver S, Mueller N. Risk factors for adult T-cell leukemia among carriers of human T-lymphotropic virus type I. Blood 1998, 92: 3557-61. PMID: 9808547, DOI: 10.1182/blood.v92.10.3557.422k09_3557_3561.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge of OnsetAgedAged, 80 and overBiomarkers, TumorCarrier StateCohort StudiesFemaleGene Products, taxHTLV-I AntibodiesHTLV-I InfectionsHuman T-lymphotropic virus 1HumansJapanLeukemia-Lymphoma, Adult T-CellMaleMiddle AgedNeoplastic Stem CellsProspective StudiesRisk FactorsSmokingT-LymphocytesConceptsAdult T-cell leukemiaHTLV-I carriersT-cell leukemiaAsymptomatic HTLV-I carriersHuman T-lymphotropic virus type IHuman T-lymphotropic virus type I.Miyazaki Cohort StudyHTLV-I antibodiesVirus type IAbnormal lymphocytesCohort studyViral markersATL diagnosisRisk factorsLow prevalenceFlower cellsATL casesGreater riskHTLVAntibodiesPositive controlType I.LeukemiaRegulatory proteinsType IRisk Factors for Adult T-Cell Leukemia Among Carriers of Human T-Lymphotropic Virus Type I
Hisada M, Okayama A, Shioiri S, Spiegelman D, Stuver S, Mueller N. Risk Factors for Adult T-Cell Leukemia Among Carriers of Human T-Lymphotropic Virus Type I. Blood 1998, 92: 3557-3561. DOI: 10.1182/blood.v92.10.3557.Peer-Reviewed Original ResearchAdult T-cell leukemiaHTLV-I carriersHuman T-lymphotropic virus type IVirus type IT-cell leukemiaAsymptomatic HTLV-I carriersMiyazaki Cohort StudyHTLV-I antibodiesType IAbnormal lymphocytesCohort studyViral markersATL diagnosisRisk factorsLow prevalenceFlower cellsATL casesGreater riskHTLVAntibodiesPositive controlLeukemiaRegulatory proteinsDiagnosisRiskPredictors of level of circulating abnormal lymphocytes among human T‐lymphotropic virus type I carriers in Japan
Hisada M, Okayama A, Tachibana N, Stuver S, Spiegelman D, Tsubouchi H, Mueller N. Predictors of level of circulating abnormal lymphocytes among human T‐lymphotropic virus type I carriers in Japan. International Journal Of Cancer 1998, 77: 188-192. PMID: 9650550, DOI: 10.1002/(sici)1097-0215(19980717)77:2<188::aid-ijc3>3.0.co;2-m.Peer-Reviewed Original ResearchConceptsHuman T-lymphotropic virus type I carriersAdult T-cell leukemiaHigh proviral loadAbnormal lymphocytesProviral loadI carriersAsymptomatic HTLV-I carriersHTLV-I carriersT-cell leukemiaMale genderMultivariate analysisMalignant cellsBlood smearsPredictors of levelsLongitudinal studyLymphocytesPredictorsHTLVLeukemiaLevelsSmears
1993
Mice Transgenic for HTLV-I LTR-tax Exhibit Tax Expression in Bone, Skeletal Alterations, and High Bone Turnover
Ruddle N, Li C, Horn W, Santiago P, Troiano N, Jay G, Horowitz M, Baron R. Mice Transgenic for HTLV-I LTR-tax Exhibit Tax Expression in Bone, Skeletal Alterations, and High Bone Turnover. Virology 1993, 197: 196-204. PMID: 8212554, DOI: 10.1006/viro.1993.1580.Peer-Reviewed Original ResearchConceptsHigh bone turnoverHTLV-I infectionBone turnoverMice transgenicSkeletal alterationsAdult T-cell leukemiaMonths of ageSpindle-shaped cellsT-cell leukemiaBone cell activityPaget's diseaseViral etiologyOsteoclast numberBone resorptionPathogenetic mechanismsBone diseaseCell leukemiaBone marrowCell activitySkeletal changesTax mRNASevere skeletal abnormalitiesHost factorsDiseaseSkeletal abnormalities
1992
A gamma delta+ T-cell leukemia bearing a novel t(8;14)(q24;q11) translocation demonstrates spontaneous in vitro natural killer-like activity.
Maziarz R, Arceci R, Bernstein S, Frazier L, Smith B, Kasai M, Tantravahi R, Strominger J. A gamma delta+ T-cell leukemia bearing a novel t(8;14)(q24;q11) translocation demonstrates spontaneous in vitro natural killer-like activity. Blood 1992, 79: 1523-31. PMID: 1532137, DOI: 10.1182/blood.v79.6.1523.bloodjournal7961523.Peer-Reviewed Original ResearchConceptsNatural killer-like activityT-cell leukemiaClinical conditionsNon-major histocompatibility complexPatient's clinical conditionGamma delta TCRTumor cell lysisFresh leukemic blastsDelta 1 gene segmentIntracellular calcium fluxGamma delta lineageT cell linesHuman T-cell leukemiaLeukemic blastsCytolytic activityDelta TCRLeukemia blastsC-myc proto-oncogene locusCalcium fluxCell surface analysisHistocompatibility complexDelta lineageLeukemiaLeukemia cellsProto-oncogene locusA γδ+ T-Cell Leukemia Bearing a Novel t(8;14)(q24;q11) Translocation Demonstrates Spontaneous In Vitro Natural Killer-Like Activity
Maziarz R, Arced R, Bernstein S, Frazier L, Smith B, Kasai M, Tantravahi R, Strominger J. A γδ+ T-Cell Leukemia Bearing a Novel t(8;14)(q24;q11) Translocation Demonstrates Spontaneous In Vitro Natural Killer-Like Activity. Blood 1992, 79: 1523-1531. DOI: 10.1182/blood.v79.6.1523.1523.Peer-Reviewed Original ResearchNatural killer-like activityT-cell leukemiaClinical conditionsNon-major histocompatibility complexPatient's clinical conditionGamma delta TCRTumor cell lysisFresh leukemic blastsDelta 1 gene segmentIntracellular calcium fluxGamma delta lineageT cell linesHuman T-cell leukemiaLeukemic blastsCytolytic activityDelta TCRLeukemia blastsC-myc proto-oncogene locusCalcium fluxCell surface analysisHistocompatibility complexDelta lineageLeukemiaLeukemia cellsProto-oncogene locus
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