2012
Cervical lidocaine for IUD insertional pain: a randomized controlled trial
McNicholas C, Madden T, Zhao Q, Secura G, Allsworth J, Peipert J. Cervical lidocaine for IUD insertional pain: a randomized controlled trial. American Journal Of Obstetrics And Gynecology 2012, 207: 384.e1-384.e6. PMID: 23107081, PMCID: PMC3492878, DOI: 10.1016/j.ajog.2012.09.018.Peer-Reviewed Original Research
2009
Lidocaine Jelly and Plain Aqueous Gel for Urethral Straight Catheterization and the Q-tip Test
Harmanli O, Okafor O, Ayaz R, Knee A. Lidocaine Jelly and Plain Aqueous Gel for Urethral Straight Catheterization and the Q-tip Test. Obstetrics And Gynecology 2009, 114: 547-550. PMID: 19701033, DOI: 10.1097/aog.0b013e3181b43808.Peer-Reviewed Original ResearchConceptsPostvoid residual volumeQ-tip testResidual volumePain scoresBaseline characteristicsLidocaine groupLidocaine jellyPain perceptionMedian pain scoreRelevant baseline characteristicsStraight catheterizationGel armWong-BakerValsalva maneuverUrethrovesical junctionCatheterLidocaineCotton swabsSwabsWomenScoresGroupCatheterizationPainJellyA Randomized, Double‐blind Controlled Study of Jet Lidocaine Compared to Jet Placebo for Pain Relief in Children Undergoing Needle Insertion in the Emergency Department
Auerbach M, Tunik M, Mojica M. A Randomized, Double‐blind Controlled Study of Jet Lidocaine Compared to Jet Placebo for Pain Relief in Children Undergoing Needle Insertion in the Emergency Department. Academic Emergency Medicine 2009, 16: 388-393. PMID: 19388923, DOI: 10.1111/j.1553-2712.2009.00401.x.Peer-Reviewed Original ResearchConceptsColor Analog ScaleSelf-reported painPain scoresEmergency departmentNeedle insertionLocal anesthetic pretreatmentMajority of patientsPlacebo-controlled designNeedle insertion painYears of ageNonintervention control groupAnesthetic pretreatmentPlacebo groupSuperior analgesiaPain reliefAnalog scaleLocal anesthesiaPatient cooperationPlaceboChildren 5Control groupPainInsertion painLidocainePatientsExploration of the African green monkey as a preclinical pharmacokinetic model: oral pharmacokinetic parameters and drug–drug interactions
Ward KW, Coon DJ, Magiera D, Bhadresa S, Struharik M, Lawrence MS. Exploration of the African green monkey as a preclinical pharmacokinetic model: oral pharmacokinetic parameters and drug–drug interactions. Xenobiotica 2009, 39: 266-272. PMID: 19280525, DOI: 10.1080/00498250802657718.Peer-Reviewed Original ResearchConceptsDrug-drug interactionsAfrican green monkeysGreen monkeysPreclinical pharmacokinetic modelKetoconazole co-administrationCo-administration experimentsHuman oral exposureOral pharmacokinetic parametersNon-human primatesOral pharmacokinetic studyCo-administrationDrug interactionsOral exposurePharmacokinetic parametersPharmacokinetic resultsOral pharmacokineticsRhesus monkeysPharmacokinetic modelPharmacokinetic screeningPharmacokinetic studyErythromycinHuman exposureLidocainePropranololMonkeys
2007
A Nav1.7 channel mutation associated with hereditary erythromelalgia contributes to neuronal hyperexcitability and displays reduced lidocaine sensitivity
Sheets PL, Jackson JO, Waxman SG, Dib‐Hajj S, Cummins TR. A Nav1.7 channel mutation associated with hereditary erythromelalgia contributes to neuronal hyperexcitability and displays reduced lidocaine sensitivity. The Journal Of Physiology 2007, 581: 1019-1031. PMID: 17430993, PMCID: PMC2170829, DOI: 10.1113/jphysiol.2006.127027.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnesthetics, LocalBinding SitesCell LineComputer SimulationDose-Response Relationship, DrugErythromelalgiaGanglia, SpinalHumansIon Channel GatingKineticsLidocaineModels, NeurologicalMutationNAV1.7 Voltage-Gated Sodium ChannelNerve Tissue ProteinsNeurons, AfferentSodium Channel BlockersSodium ChannelsTransfectionVoltage-Gated Sodium Channel beta-2 SubunitConceptsErythromelalgia mutationLidocaine inhibitionLocal anesthetic binding siteLocal anestheticsK mutationWild-type Nav1.7Use-dependent inhibitionSlow inactivationSteady-state slow inactivationAnesthetic binding sitesLidocaine sensitivityNeuronal hyperexcitabilityLidocaine treatmentSensory neuronsNaV1.7 currentsErythromelalgiaLidocaineNav1.7Electrophysiological differencesInhibitory effectChannel mutationsSodium channelsHyperexcitabilityK channelsAnesthetics
2000
Should intrathecal lidocaine be used in the 21st century?
Gaiser R. Should intrathecal lidocaine be used in the 21st century? Journal Of Clinical Anesthesia 2000, 12: 476-481. PMID: 11090735, DOI: 10.1016/s0952-8180(00)00186-0.Peer-Reviewed Original ResearchConceptsCauda equina syndromeSingle-shot spinal anesthesiaSpinal anesthesiaContinuous spinal anesthesiaIntrathecal lidocaineSafe alternativeOutpatient spinal anesthesiaPermanent neurologic injuryTransient neurologic symptomsNeurologic symptomsNeurologic injuryBack painHyperbaric lidocaineGeneral anesthesiaLithotomy positionPermanent disabilityHyperbaric 5Intrathecal useLower incidenceSafe drugHigh incidenceAnesthesiaLidocaineShort proceduresSyndromeAnserine Bursitis in Patients With Osteoarthritis of the Knee
KANG I, HAN S. Anserine Bursitis in Patients With Osteoarthritis of the Knee. Southern Medical Journal 2000, 93: 207-209. PMID: 10701790, DOI: 10.1097/00007611-200002000-00011.Peer-Reviewed Original ResearchAnserine Bursitis in Patients With Osteoarthritis of the Knee
KANG I, HAN S. Anserine Bursitis in Patients With Osteoarthritis of the Knee. Southern Medical Journal 2000, 93: 207-209. DOI: 10.1097/00007611-200093020-00011.Peer-Reviewed Original Research
1994
Epidural lidocaine versus 2-chloroprocaine for fetal distress requiring urgent cesarean section
Gaiser R, Cheek T, Gutsche B. Epidural lidocaine versus 2-chloroprocaine for fetal distress requiring urgent cesarean section. International Journal Of Obstetric Anesthesia 1994, 3: 208-210. PMID: 15636952, DOI: 10.1016/0959-289x(94)90070-1.Peer-Reviewed Original ResearchUrgent cesarean sectionNeonatal Apgar scoresUrgent cesarean deliveryNeonatal umbilical cordAcidotic fetusesApgar scoreEpidural lidocaineCesarean sectionEpidural catheterCesarean deliveryFetal distressRetrospective reviewDistressed fetusesIncision timeUmbilical cordChloroprocaineDrug AdministrationQuick onsetLidocaineTreatment populationFetusesSodium bicarbonateOnsetCatheterCord
1981
Improved observational method for studying therapeutic efficacy. Suggestive evidence that lidocaine prophylaxis prevents death in acute myocardial infarction.
Horwitz R, Feinstein A. Improved observational method for studying therapeutic efficacy. Suggestive evidence that lidocaine prophylaxis prevents death in acute myocardial infarction. JAMA 1981, 246: 2455-9. PMID: 7299968, DOI: 10.1001/jama.246.21.2455.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionRandomized clinical trialsLidocaine prophylaxisSpecial care unitsMyocardial infarctionCase-control studyClinical trialsCase-control investigationObservational case-control studyCase-control techniqueCongestive heart failureSuggestive evidenceLongitudinal studyNonarrhythmic causesPatient eligibilitySurgical treatmentVentricular arrhythmiasCare unitHeart failureTherapeutic efficacyProphylaxisPatientsPump failureLidocaineInfarction
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