2020
Forced Zika Virus Infection of Culex pipiens Leads to Limited Virus Accumulation in Mosquito Saliva
Abbo SR, Vogels CBF, Visser TM, Geertsema C, van Oers MM, Koenraadt CJM, Pijlman GP. Forced Zika Virus Infection of Culex pipiens Leads to Limited Virus Accumulation in Mosquito Saliva. Viruses 2020, 12: 659. PMID: 32575394, PMCID: PMC7354520, DOI: 10.3390/v12060659.Peer-Reviewed Original ResearchConceptsZika virusGuillain-Barré syndromeZika virus infectionInfectious blood mealUrban transmission cyclesMosquito-borne pathogenMosquito salivaZIKV transmissionOral exposureVirus infectionCongenital microcephalySevere diseaseIntrathoracic injectionLarge outbreakVirus disseminationUsutu virusMidgut barrierBarrier functionMosquito midgutVirus transmissionSalivaBlood mealYellow fever mosquitoVector competenceVirus
2017
Mosquito co-infection with Zika and chikungunya virus allows simultaneous transmission without affecting vector competence of Aedes aegypti
Göertz GP, Vogels CBF, Geertsema C, Koenraadt CJM, Pijlman GP. Mosquito co-infection with Zika and chikungunya virus allows simultaneous transmission without affecting vector competence of Aedes aegypti. PLOS Neglected Tropical Diseases 2017, 11: e0005654. PMID: 28570693, PMCID: PMC5469501, DOI: 10.1371/journal.pntd.0005654.Peer-Reviewed Original ResearchConceptsChikungunya virusZika virusAegypti mosquitoesIntrathoracic injectionPresence of ZIKVVector competenceInfectious blood mealSerious health burdenDual-color immunofluorescenceBlood mealMultiple mosquito bitesArthropod-borne virusZIKV productionSalivary gland barrierCase reportAedes aegypti mosquitoesHealth burdenOral exposureMosquito bitesViral titersPositive mosquitoesMosquito cellsBiteProfound barrierVirus
2015
Tetrafluorophenoxymethyl ketone cruzain inhibitors with improved pharmacokinetic properties as therapeutic leads for Chagas’ disease
Neitz RJ, Bryant C, Chen S, Gut J, Caselli EH, Ponce S, Chowdhury S, Xu H, Arkin MR, Ellman JA, Renslo AR. Tetrafluorophenoxymethyl ketone cruzain inhibitors with improved pharmacokinetic properties as therapeutic leads for Chagas’ disease. Bioorganic & Medicinal Chemistry Letters 2015, 25: 4834-4837. PMID: 26144347, PMCID: PMC4737481, DOI: 10.1016/j.bmcl.2015.06.066.Peer-Reviewed Original ResearchConceptsCruzain inhibitorsCysteine protease cruzainAnimal modelsSubstrate Activity ScreeningPharmacokinetic propertiesImproved pharmacokinetic propertiesVivo pharmacokinetic propertiesNew chemotherapeutic approachesKetone inhibitorsNew analoguesPromising efficacyReduced lipophilicityOral exposureTherapeutic leadsChemotherapeutic approachesCruzainEfficacious effectsChagas diseaseTherapeutic hypothesesDiseaseNew classInhibitorsTrypanosoma cruziP3 positionPotency
2011
Induction of Persistent Depressive-Like Behavior by Corticosterone
Gourley S, Taylor J. Induction of Persistent Depressive-Like Behavior by Corticosterone. Neuromethods 2011, 63: 251-265. DOI: 10.1007/978-1-61779-313-4_16.Peer-Reviewed Original ResearchChronic CORT exposureDepressive-like behaviorCORT exposureChronic depressive-like stateChronic mild stress modelStress-related mood disordersChronic antidepressant treatmentSerum CORT levelsNeurobiology of depressionDepressive-like stateChronic oral exposureCharacteristics of depressionAntidepressant efficacyAntidepressant treatmentAdrenal hormonesOral exposureMood disordersFeelings of anhedoniaLocomotor activityNaïve rodentsCORT levelsCorticosteroneDepressionBehavioral consequencesExposure
2009
Recapitulation and Reversal of a Persistent Depression‐like Syndrome in Rodents
Gourley SL, Taylor JR. Recapitulation and Reversal of a Persistent Depression‐like Syndrome in Rodents. Current Protocols In Neuroscience 2009, 49: 9.32.1-9.32.11. PMID: 19802817, PMCID: PMC2774936, DOI: 10.1002/0471142301.ns0932s49.Peer-Reviewed Original ResearchConceptsCORT exposureChronic mild stress modelChronic antidepressant treatmentChronic CORT exposureHelplessness-like behaviorDepressive-like stateNeurobiology of depressionDepression-like syndromeChronic oral exposureAntidepressant efficacyAntidepressant treatmentAdrenal hormonesOral exposureNucleus accumbensMouse modelFeelings of anhedoniaNaïve rodentsMultiple biological functionsMolecular targetsCAMP response elementDepressionFactor activityCorticosteroneExposure periodExposureExploration of the African green monkey as a preclinical pharmacokinetic model: oral pharmacokinetic parameters and drug–drug interactions
Ward KW, Coon DJ, Magiera D, Bhadresa S, Struharik M, Lawrence MS. Exploration of the African green monkey as a preclinical pharmacokinetic model: oral pharmacokinetic parameters and drug–drug interactions. Xenobiotica 2009, 39: 266-272. PMID: 19280525, DOI: 10.1080/00498250802657718.Peer-Reviewed Original ResearchConceptsDrug-drug interactionsAfrican green monkeysGreen monkeysPreclinical pharmacokinetic modelKetoconazole co-administrationCo-administration experimentsHuman oral exposureOral pharmacokinetic parametersNon-human primatesOral pharmacokinetic studyCo-administrationDrug interactionsOral exposurePharmacokinetic parametersPharmacokinetic resultsOral pharmacokineticsRhesus monkeysPharmacokinetic modelPharmacokinetic screeningPharmacokinetic studyErythromycinHuman exposureLidocainePropranololMonkeys
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