2021
Repeated infusion of mesenchymal stem cells maintain the condition to inhibit deteriorated motor function, leading to an extended lifespan in the SOD1G93A rat model of amyotrophic lateral sclerosis
Magota H, Sasaki M, Kataoka-Sasaki Y, Oka S, Ukai R, Kiyose R, Onodera R, Kocsis JD, Honmou O. Repeated infusion of mesenchymal stem cells maintain the condition to inhibit deteriorated motor function, leading to an extended lifespan in the SOD1G93A rat model of amyotrophic lateral sclerosis. Molecular Brain 2021, 14: 76. PMID: 33962678, PMCID: PMC8103621, DOI: 10.1186/s13041-021-00787-6.Peer-Reviewed Original ResearchConceptsAmyotrophic lateral sclerosisAdministration of MSCsSingle infusionMesenchymal stem cellsMotor functionGait abilityDisease progressionMotor neuronsRat modelLateral sclerosisBlood-spinal cord barrierSOD1G93A rat modelSpinal cord degenerateVehicle infusion groupHind limb functionALS rat modelStem cellsLimb functionVehicle infusionFatal disorderSurvival periodTherapeutic effectLocomotor activityInfusionProgressive deteriorationIntravenous infusion of mesenchymal stem cells delays disease progression in the SOD1G93A transgenic amyotrophic lateral sclerosis rat model
Magota H, Sasaki M, Kataoka-Sasaki Y, Oka S, Ukai R, Kiyose R, Onodera R, Kocsis JD, Honmou O. Intravenous infusion of mesenchymal stem cells delays disease progression in the SOD1G93A transgenic amyotrophic lateral sclerosis rat model. Brain Research 2021, 1757: 147296. PMID: 33516815, DOI: 10.1016/j.brainres.2021.147296.Peer-Reviewed Original ResearchConceptsBlood-spinal cord barrierQuantitative reverse transcription polymerase chain reactionIntravenous infusionDisease progressionMotor neuronsMSC groupLocomotor functionOpen-field locomotor functionPreservation of microvasculatureHind limb functionCommon clinical featuresEvans blue leakageMotor neuron lossReverse transcription-polymerase chain reactionTranscription-polymerase chain reactionDevastating neurodegenerative diseaseBBB scoringBSCB functionRotarod testingClinical featuresNeuron lossLimb functionNeurotrophic factorCurative strategiesSpinal cord
2013
Endovascular coil embolization of segmental arteries prevents paraplegia after subsequent thoracoabdominal aneurysm repair: An experimental model
Geisbüsch S, Stefanovic A, Koruth JS, Lin HM, Morgello S, Weisz DJ, Griepp RB, Di Luozzo G. Endovascular coil embolization of segmental arteries prevents paraplegia after subsequent thoracoabdominal aneurysm repair: An experimental model. Journal Of Thoracic And Cardiovascular Surgery 2013, 147: 220-227. PMID: 24220154, PMCID: PMC3918675, DOI: 10.1016/j.jtcvs.2013.09.022.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAortic Aneurysm, ThoracicBlood Vessel Prosthesis ImplantationEmbolization, TherapeuticEndovascular ProceduresHindlimbLumbosacral RegionModels, AnimalMuscle, SkeletalParaplegiaRecovery of FunctionRegional Blood FlowSpinal Cord IschemiaSwineThoracic ArteriesTime FactorsVideo RecordingConceptsSpinal cord injuryThoracoabdominal aneurysm repairHind limb functionSegmental arteriesTAAA repairAneurysm repairCord injuryGroup 2Tarlov scoreLimb functionCoil embolizationExperimental modelSpinal cordGroup 1Ischemic spinal cord injuryPostoperative spinal cord injuryHybrid TAAA repairJuvenile Yorkshire pigsLumbar segmental arteriesModified Tarlov scoreEndovascular coil embolizationLower thoracic/upper lumbar regionUpper lumbar regionPrevents paraplegiaHistopathologic injury
2011
Staged Approach Prevents Spinal Cord Injury in Hybrid Surgical-Endovascular Thoracoabdominal Aortic Aneurysm Repair: An Experimental Model
Bischoff MS, Scheumann J, Brenner RM, Ladage D, Bodian CA, Kleinman G, Ellozy SH, Di Luozzo G, Etz CD, Griepp RB. Staged Approach Prevents Spinal Cord Injury in Hybrid Surgical-Endovascular Thoracoabdominal Aortic Aneurysm Repair: An Experimental Model. The Annals Of Thoracic Surgery 2011, 92: 138-146. PMID: 21718839, DOI: 10.1016/j.athoracsur.2011.03.098.Peer-Reviewed Original ResearchMeSH KeywordsAngiographyAngioplastyAnimalsAortic Aneurysm, ThoracicCombined Modality TherapyDisease Models, AnimalFemaleFollow-Up StudiesIntraoperative ComplicationsMonitoring, IntraoperativeRandom AllocationRisk AssessmentSpinal CordSpinal Cord InjuriesStentsSurvival RateSwineTreatment OutcomeVascular Surgical ProceduresConceptsGroup 1Group 2Thoracoabdominal aortic aneurysm repairJuvenile Yorkshire pigsSevere ischemic damageHind limb functionAortic aneurysm repairStent graft occlusionLumbar spinal cordModified Tarlov scoreSpinal cord injuryEndovascular coverageTarlov scoreGraft occlusionAneurysm repairArtery ligationIntercostal arteriesIschemic damageCord injuryLimb functionSudden occlusionSpinal cordLower thoracicHistopathologic analysisPorcine model
2010
Experimental Two-Stage Simulated Repair of Extensive Thoracoabdominal Aneurysms Reduces Paraplegia Risk
Zoli S, Etz CD, Roder F, Brenner RM, Bodian CA, Kleinman G, Di Luozzo G, Griepp RB. Experimental Two-Stage Simulated Repair of Extensive Thoracoabdominal Aneurysms Reduces Paraplegia Risk. The Annals Of Thoracic Surgery 2010, 90: 722-729. PMID: 20732484, DOI: 10.1016/j.athoracsur.2010.04.047.Peer-Reviewed Original ResearchConceptsSpinal cord perfusion pressureHind limb functionGroup 2Artery sacrificeLimb functionExtensive segmental artery sacrificeExtensive thoracoabdominal aneurysmsJuvenile Yorkshire pigsSevere ischemic damageMotor-evoked potentialsLumbar spinal cordSpinal cord functionModified Tarlov scoreSpinal cord injuryParaplegia riskTarlov scoreThoracoabdominal aneurysmsAneurysm repairCord functionDistal stumpIschemic damagePerfusion pressureCord injurySpinal cordLower thoracic
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply