2023
PPP1R12C Promotes Atrial Hypocontractility in Atrial Fibrillation
Perike S, Gonzalez-Gonzalez F, Abu-Taha I, Damen F, Hanft L, Lizama K, Aboonabi A, Capote A, Aguilar-Sanchez Y, Levin B, Han Z, Sridhar A, Grand J, Martin J, Akar J, Warren C, Solaro R, Ong S, Darbar D, McDonald K, Goergen C, Wolska B, Dobrev D, Wehrens X, McCauley M. PPP1R12C Promotes Atrial Hypocontractility in Atrial Fibrillation. Circulation Research 2023, 133: 758-771. PMID: 37737016, PMCID: PMC10616980, DOI: 10.1161/circresaha.123.322516.Peer-Reviewed Original ResearchConceptsSinus rhythm controlsAtrial hypocontractilityAF inducibilityAtrial contractilityAtrial fibrillationRhythm controlHuman patientsRight atrial appendage tissuePacing-induced AFThromboembolic stroke riskAtrial ejection fractionAtrial appendage tissueAtrial HL-1 cellsHL-1 cellsAtrial strainStroke riskAtrial sizeEjection fractionContractile functionElectrophysiology studyHypocontractilityWestern blotPatientsAtrial myosin light chainSarcomere function
2021
An interesting response to adenosine during right ventricular pacing. What is the mechanism?
Gupta A, Vinocur JM. An interesting response to adenosine during right ventricular pacing. What is the mechanism? Journal Of Electrocardiology 2021, 68: 41-43. PMID: 34311213, DOI: 10.1016/j.jelectrocard.2021.07.010.Peer-Reviewed Case Reports and Technical NotesConceptsRight ventricular pacingSingle doseVentricular pacingWolff-ParkinsonWhite syndromeElectrophysiology study
2012
Electrophysiology Studies in Patients Undergoing ICD Implantation: Findings from the NCDR®
CHENG A, WANG Y, BERGER RD, CALKINS H, BUXTON AE, CURTIS JP, LAMPERT R. Electrophysiology Studies in Patients Undergoing ICD Implantation: Findings from the NCDR®. Pacing And Clinical Electrophysiology 2012, 35: 912-918. PMID: 22670627, DOI: 10.1111/j.1540-8159.2012.03441.x.Peer-Reviewed Original ResearchConceptsICD implantationElectrophysiology studyEjection fractionSudden deathDe novo ICD implantationSecondary prevention ICD recipientsSudden death risk stratificationLeft ventricular ejection fractionImplantable cardioverter defibrillator implantationNarrow QRS intervalPrimary prevention ICDsDeath risk stratificationCardioverter-defibrillator implantationCongestive heart failureVentricular ejection fractionHigher ejection fractionHistory of syncopeMonomorphic ventricular tachycardiaLogistic regression analysisFuture ICD therapyHierarchical logistic regression analysisICD therapyClinical characteristicsComplication rateDefibrillator implantation
2008
Organized Incessant Atrial Arrhythmias in the Setting of Severe, Isolated Biatrial Scarring
MASSUMI A, RASEKH A, SAEED M, FLAM S, CHEONG B, MOJIBIAN H, RAZAVI M. Organized Incessant Atrial Arrhythmias in the Setting of Severe, Isolated Biatrial Scarring. Pacing And Clinical Electrophysiology 2008, 31: 666-675. PMID: 18507538, DOI: 10.1111/j.1540-8159.2008.01069.x.Peer-Reviewed Original ResearchConceptsAtrial arrhythmiasMagnetic resonance imagingRight atrialAtrial dilationLeft atrialAtrioventricular nodal ablationHigh-output pacingCARTO mappingDiffuse scarringAtrial dimensionAtrial standstillMRI findingsNodal ablationAtrial scarringVentricular dimensionsSystemic diseaseRight atriumSevere scarringElectroanatomic mappingCARTO systemEntrainment mappingElectrical silenceStructural heartElectrophysiology studyTransmural fibrosis
2005
A Novel Positive Allosteric Modulator of the α7 Neuronal Nicotinic Acetylcholine Receptor: In Vitro and In Vivo Characterization
Hurst R, Hajós M, Raggenbass M, Wall T, Higdon N, Lawson J, Rutherford-Root K, Berkenpas M, Hoffmann W, Piotrowski D, Groppi V, Allaman G, Ogier R, Bertrand S, Bertrand D, Arneric S. A Novel Positive Allosteric Modulator of the α7 Neuronal Nicotinic Acetylcholine Receptor: In Vitro and In Vivo Characterization. Journal Of Neuroscience 2005, 25: 4396-4405. PMID: 15858066, PMCID: PMC6725110, DOI: 10.1523/jneurosci.5269-04.2005.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcholineAcoustic StimulationAllosteric Regulationalpha7 Nicotinic Acetylcholine ReceptorAmphetamineAnimalsAnimals, NewbornCalciumCell LineCentral Nervous System StimulantsCholinergic AgonistsCholinergic AntagonistsDose-Response Relationship, DrugDrug InteractionsElectric StimulationEpithelial CellsEvoked Potentials, AuditoryHippocampusHumansIn Vitro TechniquesIsoxazolesMaleMembrane PotentialsMicroinjectionsNeuronsNicotineOocytesPatch-Clamp TechniquesPhenylurea CompoundsProtein SubunitsRatsRats, Sprague-DawleyReceptors, NicotinicTetrodotoxinTime FactorsXenopusConceptsNeuronal nicotinic acetylcholine receptorsPNU-120596Positive allosteric modulatorsNicotinic acetylcholine receptorsAlpha7 nAChRsAcetylcholine receptorsPowerful positive allosteric modulatorAllosteric modulatorsAlpha7 neuronal nicotinic acetylcholine receptorΑ7 neuronal nicotinic acetylcholine receptorsNovel positive allosteric modulatorGABAergic postsynaptic currentsAcute hippocampal slicesTraumatic brain injuryFrequency of AChAgonist-evoked currentsPresence of agonistPyramidal neuronsHippocampal interneuronsPostsynaptic currentsBrain injuryHippocampal slicesSystemic administrationElectrophysiology studySomatodendritic membrane
1982
The Ultrastructure of the Distal Tubule of Amphiuma: A Tem and Sem Study
Biemesderfer D, Stanton B, Kashgarian M, Giebisch G. The Ultrastructure of the Distal Tubule of Amphiuma: A Tem and Sem Study. Microscopy And Microanalysis 1982, 40: 170-171. DOI: 10.1017/s0424820100053541.Peer-Reviewed Original Research
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