Shared Genetic Architecture Among Gastrointestinal Diseases, Schizophrenia, and Brain Subcortical Volumes
Xie Y, Zhao Y, Zhou Y, Jiang Y, Zhang Y, Du J, Cai M, Fu J, Liu H. Shared Genetic Architecture Among Gastrointestinal Diseases, Schizophrenia, and Brain Subcortical Volumes. Schizophrenia Bulletin 2024, 50: 1243-1254. PMID: 38973257, PMCID: PMC11349026, DOI: 10.1093/schbul/sbae099.Peer-Reviewed Original ResearchConceptsLocal genetic correlationProtein-protein interactionsPolygenic overlapGenetic architectureBrain subcortical volumesGenome-wide association study dataSubcortical volumesProtein-protein interaction analysisCell-type enrichmentGenetic correlationsFunctional annotationGut-brain axisHub genesGenetic mechanismsGenetic variantsColocalization analysisBiological processesImmune systemData of schizophreniaGenesDevelopment of interventionsSchizophreniaGastrointestinal diseasesTherapy targetGI diseases
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