2013
Mapping phosphorylation rate of fluoro-deoxy-glucose in rat brain by 19F chemical shift imaging
Coman D, Sanganahalli BG, Cheng D, McCarthy T, Rothman DL, Hyder F. Mapping phosphorylation rate of fluoro-deoxy-glucose in rat brain by 19F chemical shift imaging. Magnetic Resonance Imaging 2013, 32: 305-313. PMID: 24581725, PMCID: PMC3965601, DOI: 10.1016/j.mri.2013.10.015.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsAnimalsBrainFluorodeoxyglucose F18Glucose-6-PhosphateMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMetabolic Clearance RateMolecular ImagingPhosphorylationPhosphotransferasesRadionuclide ImagingRadiopharmaceuticalsRatsRats, Inbred LewReproducibility of ResultsSensitivity and SpecificityTissue DistributionConceptsRat brainChemical shift imagingHalothane-anesthetized ratsMagnetic resonance spectroscopy studyTotal glucose metabolismMinimal side effectsMagnetic resonance imaging (MRI) measurementsFunctional magnetic resonance imaging (fMRI) measurementsFDG phosphorylationFMRI BOLD responsesCerebral physiologyForepaw stimulationShift imagingGlucose metabolismSide effectsBrain tissueFDGExtracted tissuesTumor pathophysiologyBrainMRS measurementsTissue componentsVivo detectionVivoD-glucose
1999
Hexokinase in Astrocytes: Kinetic and Regulatory Properties
Lai J, Behar K, Liang B, Hertz L. Hexokinase in Astrocytes: Kinetic and Regulatory Properties. Metabolic Brain Disease 1999, 14: 125-133. PMID: 10488914, DOI: 10.1023/a:1020761831295.Peer-Reviewed Original Research
1997
Local ventromedial hypothalamus glucose perfusion blocks counterregulation during systemic hypoglycemia in awake rats.
Borg MA, Sherwin RS, Borg WP, Tamborlane WV, Shulman GI. Local ventromedial hypothalamus glucose perfusion blocks counterregulation during systemic hypoglycemia in awake rats. Journal Of Clinical Investigation 1997, 99: 361-365. PMID: 9006005, PMCID: PMC507804, DOI: 10.1172/jci119165.Peer-Reviewed Original ResearchConceptsVentromedial hypothalamic nucleusMM D-glucoseControl groupGlucose perfusionHypoglycemic counterregulationSystemic hypoglycemiaNorepinephrine releaseGlucagon secretionCatecholamine concentrationsHypothalamic nucleiAwake ratsHormonal secretionControl animalsHypoglycemiaHormonal responsesPerfusionL glucoseCounterregulationD-glucoseGlucagonRatsSecretionGlucoseAnimalsGlucopenia
1987
Electrochemical analysis of renal Na+-glucose cotransport in salamander proximal tubules
Morgunov N, Boulpaep E. Electrochemical analysis of renal Na+-glucose cotransport in salamander proximal tubules. American Journal Of Physiology 1987, 252: f154-f169. PMID: 3812699, DOI: 10.1152/ajprenal.1987.252.1.f154.Peer-Reviewed Original ResearchConceptsLuminal glucoseProximal tubulesFavorable chemical gradientFavorable electrical gradientSodium concentrationSodium-glucose cotransporterIntracellular sodium activityElectrogenic responseSodium activityMM D-glucoseMembrane potentialSalamander proximal tubuleLuminal perfusateOmega X cm2Glucose cotransportGlucose concentrationLuminal membranePhysiological rangeX cm2Luminal membrane potentialGlucoseD-glucoseTubulesLuminal membrane resistancePerfusate
1984
Treatment of Insulin Reactions in Diabetics
Brodows R, Williams C, Amatruda J. Treatment of Insulin Reactions in Diabetics. JAMA 1984, 252: 3378-3381. PMID: 6389915, DOI: 10.1001/jama.1984.03350240024032.Peer-Reviewed Original ResearchConceptsGlycemic responsePlasma free insulin concentrationInsulin-dependent diabeticsFree insulin concentrationsMicroU/mLGlucose clamp techniquePlasma glucose levelsRebound hyperglycemiaSevere hypoglycemiaOutpatient settingSpontaneous episodesInsulin concentrationsInsulin reactionGlucose levelsClamp techniqueHypoglycemiaIngested carbohydrateD-glucoseDiabeticsOrange juiceTreatmentImportant determinantCommon sourceHyperglycemiaPatients
1975
The Na+ gradient-dependent transport of D-glucose in renal brush border membranes.
Aronson P, Sacktor B. The Na+ gradient-dependent transport of D-glucose in renal brush border membranes. Journal Of Biological Chemistry 1975, 250: 6032-6039. PMID: 1150669, DOI: 10.1016/s0021-9258(19)41154-x.Peer-Reviewed Original ResearchConceptsRenal brush border membraneBrush border membraneD-glucose transportNa+ gradientUptake of D-glucoseD-glucose uptakeBorder membraneTransport of D-glucoseNa+-dependent transportRabbit renal cortexD-glucoseLuminal membraneRenal cortexNa+-dependent transport systemIntact preparationsNa+-independent systemCis-stimulationPhysiological concentrations of D-glucoseD-glucose transport systemStimulatory effectConcentrations of sugarsBrush border membrane vesiclesNa+ effectMembranes in vitro
1974
Further Studies on the Previously Proposed Saturable High Affinity Site for d-Glucose in Renal Brush Border Membrane Preparations
Mitchell M, Aronson P, Sacktor B. Further Studies on the Previously Proposed Saturable High Affinity Site for d-Glucose in Renal Brush Border Membrane Preparations. Journal Of Biological Chemistry 1974, 249: 6971-6975. PMID: 4420797, DOI: 10.1016/s0021-9258(19)42153-4.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBinding SitesBinding, CompetitiveBiological Transport, ActiveCarbon RadioisotopesCell MembraneDeoxyglucoseGalactoseGlucoseIsotope LabelingKidneyKineticsMannoseMathematicsMethylglucosidesPenicillinsPhlorhizinProtein BindingPseudomonasRabbitsReceptors, DrugSodiumStereoisomerismStreptomycinTemperatureTime FactorsTritiumConceptsHigh-affinity siteStereospecific uptakeBrush border preparationsSaturable high affinity sitesD-glucoseStereospecific uptake of D-glucoseUptake of D-glucoseAffinity sitesGenus PseudomonasIncubation periodPresence of penicillinSensitive to preincubationBacterial contaminationBacterial growthConcentrations of D-glucoseAffinity bindingHigher concentrationsIncubationContaminationBrush borderBrush border membrane preparationsTransport of d-glucose by brush border membranes isolated from the renal cortex
Aronson P, Sacktor B. Transport of d-glucose by brush border membranes isolated from the renal cortex. Biochimica Et Biophysica Acta 1974, 356: 231-243. PMID: 4855244, DOI: 10.1016/0005-2736(74)90286-7.Peer-Reviewed Original ResearchConceptsRate of D-glucose uptakeD-glucose uptakeUptake of D-glucoseEfflux of D-glucoseD-glucoseBrush border membraneRenal cortexD-glucose transportBorder membraneNa+-free mediumEffective model systemNa+ gradient hypothesisTransport of D-glucoseGradient hypothesisRabbit renal cortexConcentrations of D-glucoseAbsence of Na+Renal brush border membraneIsolated renal brush border membranesMembrane vesiclesRenal brush borderNa+-freeD-galactoseIntact preparationsBrush border membrane vesicles
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