2025
Identification of F-box proteins in ABA- and GA-regulated seed germination: interaction of GASA1 signalling peptide and ABA-induced ubiquitination
Kasera M, Ceciliato P, Lopez B, Hauser F, Gendron J, Schroeder J. Identification of F-box proteins in ABA- and GA-regulated seed germination: interaction of GASA1 signalling peptide and ABA-induced ubiquitination. Philosophical Transactions Of The Royal Society B Biological Sciences 2025, 380: 20240233. PMID: 40439299, PMCID: PMC12121378, DOI: 10.1098/rstb.2024.0233.Peer-Reviewed Original ResearchConceptsSeed germinationSignal peptideGenetic screeningF-box proteinsForward genetic screensHomology-based gene silencingInhibition of seed germinationABA-insensitiveHomologous genesFunctional genomicsGene familyTriple mutantF-boxABA inhibitionProteasome pathwayAmiRNA linesGene silencingInteraction partnersGerminating seedsArtificial microRNAGenesABAGerminationMutantsUbiquitinAssociation between methyl-CpG-binding domain protein 5 gene and depressive symptoms in Mexican population: Results from MxGDAR/Encodat cohort.
Sanabrais-Jiménez M, Camarena B, Aguilar-García A, Genis-Mendoza A, Martínez-Magaña J, Nicolini H, Villatoro-Velá J, Bustos-Gamiño M, Gutiérrez-López M, Medina-Mora M. Association between methyl-CpG-binding domain protein 5 gene and depressive symptoms in Mexican population: Results from MxGDAR/Encodat cohort. Brazilian Journal Of Psychiatry 2025 PMID: 39787278, DOI: 10.47626/1516-4446-2024-3859.Peer-Reviewed Original ResearchDepressive symptomsAnxiety symptomsGenetic principal componentsMexican populationScreening QuestionnaireDepressive symptomatologyMexican cohortLogistic regression approachHealthy controlsAddiction researchDevelopment of DSDI padAnxietyCohortAssociationSymptomsMBD5Gene silencingGenesPopulationQuestionnairePLINKMYO1HSymptomatologySex
2020
Salmonella expresses foreign genes during infection by degrading their silencer
Choi J, Groisman EA. Salmonella expresses foreign genes during infection by degrading their silencer. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 8074-8082. PMID: 32209674, PMCID: PMC7149492, DOI: 10.1073/pnas.1912808117.Peer-Reviewed Original ResearchConceptsForeign genesH-NSForeign DNAHeat-stable nucleoid-structuring (H-NS) proteinH-NS bindingNucleoid structuring proteinGram-negative bacterial speciesFacultative intracellular pathogenPhoP proteinLon proteaseProtease LonRegulatory sequencesVirulence regulatorGene silencingIntramacrophage survivalStructuring proteinBacterial speciesGenesInside macrophagesIntracellular pathogensSerovar TyphimuriumUncovered mechanismProteinVirulence genesDNA
2016
CSN1 Somatic Mutations in Penile Squamous Cell Carcinoma
Feber A, Worth D, Chakravarthy A, de Winter P, Shah K, Arya M, Saqib M, Nigam R, Malone P, Tan W, Rodney S, Freeman A, Jameson C, Wilson G, Powles T, Beck S, Fenton T, Sharp T, Muneer A, Kelly J. CSN1 Somatic Mutations in Penile Squamous Cell Carcinoma. Cancer Research 2016, 76: 4720-4727. PMID: 27325650, PMCID: PMC5302160, DOI: 10.1158/0008-5472.can-15-3134.Peer-Reviewed Original ResearchConceptsWhole-exome sequencingResequencing of candidate genesPenile cancerMiRNA-mediated gene silencingCytoplasmic P-bodiesCopy-number informationAnalysis of somatic alterationsSomatic mutation landscapeDevelopment of penile cancerPenile squamous cell carcinomaTargeted resequencingCandidate genesDNA methylationGene silencingHPV-negative diseaseP-bodiesRecurrent mutationsLandscape of alterationsAPOBEC mutational signaturesSquamous cell carcinomaGermline DNASomatic alterationsMutation dataMutational signaturesGenetic alterationsImaging Functional Nucleic Acid Delivery to Skin
Kaspar RL, Hickerson RP, González-González E, Flores MA, Speaker TP, Rogers FA, Milstone LM, Contag CH. Imaging Functional Nucleic Acid Delivery to Skin. Methods In Molecular Biology 2016, 1372: 1-24. PMID: 26530911, DOI: 10.1007/978-1-4939-3148-4_1.Peer-Reviewed Original ResearchConceptsNucleic acid deliveryNucleic acid-based therapiesAcid deliveryAcid-based therapiesFunctional deliveryFunctional nucleic acid deliveryTherapeutic nucleic acidsNucleic acidsOptical imaging technologiesReal-time monitoringTriplex nucleic acidsInteraction of lightMonogenic skin diseasesLight-tissue interactionsGene editingGene silencingOptical imagingNoninvasive imaging technologyTopical deliveryTime monitoringImaging technologyReporter geneLayered structureGeneral strategyEnzymatic reactions
2015
Chitosan, Carbon Quantum Dot, and Silica Nanoparticle Mediated dsRNA Delivery for Gene Silencing in Aedes aegypti: A Comparative Analysis
Das S, Debnath N, Cui Y, Unrine J, Palli SR. Chitosan, Carbon Quantum Dot, and Silica Nanoparticle Mediated dsRNA Delivery for Gene Silencing in Aedes aegypti: A Comparative Analysis. ACS Applied Materials & Interfaces 2015, 7: 19530-19535. PMID: 26291176, DOI: 10.1021/acsami.5b05232.Peer-Reviewed Original Research
2010
[The development of vector constructions for respiratory syncitial virus (RSV) P-gene silencing].
Shilovskiĭ I, Mazurov D, Khaitov M. [The development of vector constructions for respiratory syncitial virus (RSV) P-gene silencing]. Патологическая Физиология И Экспериментальная Терапия 2010, 11-6. PMID: 21400723.Peer-Reviewed Original ResearchConceptsLevels of target RNAGene expressionBamH I restriction sitesKnock down gene expressionLevels of mRNASilence gene expressionCMV promoterExpressing shRNAShRNA constructsEfficient gene silencingShRNA sequencesPhosphoprotein PRestriction sitesRISC complexShRNATarget RNAVirus replicationGene silencingInterference RNAOriginal recombinantHuman CD43MRNA silencingTarget mRNAsCell cytoplasmMA-104
2009
DNA excision repair proteins and Gadd45 as molecular players for active DNA demethylation
Ma D, Guo J, Ming G, Song H. DNA excision repair proteins and Gadd45 as molecular players for active DNA demethylation. Cell Cycle 2009, 8: 1526-1531. PMID: 19377292, PMCID: PMC2738863, DOI: 10.4161/cc.8.10.8500.Peer-Reviewed Original ResearchConceptsActive DNA demethylationDNA demethylationProcess of DNA demethylationMolecular playersProcess of DNA methylationHeritable gene silencingDNA cytosine methylationClass of methyltransferasesDNA demethylation mechanismTransgenerational epigenetic inheritanceDNA excision repair proteinNucleotide-excision repairExcision repair proteinsHeterochromatin formationCytosine methylationExcision repair enzymesEpigenetic inheritanceEvolutionary implicationsDNA methylationGene silencingModification signalsEnzymatic machineryDemethylation mechanismRepair enzymesRepair proteins
2008
Epigenetic Inactivation of the Canonical Wnt Antagonist SRY-Box Containing Gene 17 in Colorectal Cancer
Zhang W, Glöckner S, Guo M, Machida EO, Wang DH, Easwaran H, Van Neste L, Herman JG, Schuebel KE, Watkins DN, Ahuja N, Baylin SB. Epigenetic Inactivation of the Canonical Wnt Antagonist SRY-Box Containing Gene 17 in Colorectal Cancer. Cancer Research 2008, 68: 2764-2772. PMID: 18413743, PMCID: PMC2823123, DOI: 10.1158/0008-5472.can-07-6349.Peer-Reviewed Original ResearchConceptsGene 17T-cell factor-dependent transcriptionHigh-mobility group transcription factorsFactor-dependent transcriptionMethylation-dependent silencingRegulation of developmentOverexpression of Sox17Cell linesCpG island hypermethylationWnt pathway activityPrecursor cell functionRepression domainHMG boxTranscription factorsDeletion analysisCpG islandsGene silencingDNA hypermethylationGene expressionPromoter regionEpigenetic inactivationCanonical WntGenetic changesIsland hypermethylationSOX17
2007
Targeting of cell survival genes using small interfering RNAs (siRNAs) enhances radiosensitivity of Grade II chondrosarcoma cells
Kim DW, Seo SW, Cho SK, Chang SS, Lee HW, Lee E, Block JA, Hei TK, Lee FY. Targeting of cell survival genes using small interfering RNAs (siRNAs) enhances radiosensitivity of Grade II chondrosarcoma cells. Journal Of Orthopaedic Research® 2007, 25: 820-828. PMID: 17343283, DOI: 10.1002/jor.20377.Peer-Reviewed Original ResearchMeSH KeywordsApoptosisApoptosis Regulatory Proteinsbcl-X ProteinBone NeoplasmsCell Line, TumorCell SurvivalChondrocytesChondrosarcomaGene Expression Regulation, NeoplasticHumansProto-Oncogene Proteins c-bcl-2Radiation ToleranceRNA, MessengerRNA, Small InterferingX-Linked Inhibitor of Apoptosis ProteinConceptsBcl-xLCell deathChondrosarcoma cellsGene silencingBcl-2Cell survival genesHuman chondrosarcoma cell lineClonogenic survival assaysChondrosarcoma cell linesNovel therapeutic conceptsCorresponding siRNAAntiapoptotic genesApoptotic pathwaySurvival genesAntiapoptotic mRNAsCell survivalXIAP geneMost chondrosarcomasAdjuvant therapySurgical resectionGenesSurvival assaysTherapeutic conceptsCell linesSilencing
1999
The Cadherin-Catenin System: Implications for Growth and Differentiation of Endocrine Tissues
Pötter E, Bergwitz C, Brabant G. The Cadherin-Catenin System: Implications for Growth and Differentiation of Endocrine Tissues. Endocrine Reviews 1999, 20: 207-239. PMID: 10204118, DOI: 10.1210/edrv.20.2.0362.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCadherin-catenin systemBeta-catenin/TCF4 complexComplex signal transduction pathwaysCell-cell adhesionNormal cell functionSignal transduction pathwaysLoss-of-functionRegulate cellular differentiationActivation of oncogenesEpigenetic mechanismsExtracellular modulatorsTransduction pathwaysTCF4 complexPosttranscriptional eventsCellular differentiationEndocrine tissuesIntracellular signalingGenetic mouse modelsProcess of tumorigenesisCadherin-cateninsSomatic gene mutationsPreservation of tissue integrityGene silencingCell adhesionC-Myc
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