2025
Key challenges and recommendations for defining organelle membrane contact sites
Calì T, Bayer E, Eden E, Hajnóczky G, Kornmann B, Lackner L, Liou J, Reinisch K, Rhee H, Rizzuto R, Scorrano L, Brini M. Key challenges and recommendations for defining organelle membrane contact sites. Nature Reviews Molecular Cell Biology 2025, 1-21. PMID: 40550870, DOI: 10.1038/s41580-025-00864-x.Peer-Reviewed Original ResearchMembrane contact sitesContact sitesContact site formationMembrane-bound compartmentsOrganelle interactionsTethering proteinsExtracellular stimuliCellular functionsCellular signalingSuper-resolution microscopyProteomic approachReporter constructsMolecular playersSite dynamicsOrganellesSite formationProteinPhysiological conditionsElectron tomographyExperimental approachExchange of ionsSitesPathological conditionsGeneticsMass spectrometryTNFRSF1A and NCF1 May Act as Hub Genes in Mastitis
Ekhtiyari M, Yousefi M, Samadian F, Ghaderi‐Zefrehei M, Neysi S, Shamsabadi J, Javanmard A, Shahriarpour H, Lesch B. TNFRSF1A and NCF1 May Act as Hub Genes in Mastitis. Veterinary Medicine And Science 2025, 11: e70278. PMID: 40028770, PMCID: PMC11875065, DOI: 10.1002/vms3.70278.Peer-Reviewed Original ResearchConceptsBovine mastitisHub genesMastitis susceptibilityExpression datasetsMolecular mechanismsMultiple expression datasetsProtein-protein interactionsCo-expression network analysisSusceptibility to bovine mastitisRegulatory networksTarget key genesKey genesDairy industryMolecular playersNetwork analysisMRNA-miRNACo-expressionGenesNCF1MastitisBacterial infectionsTherapeutic targetTNFRSF1AImmune responseSusceptibility
2024
Sorting of secretory proteins at the trans-Golgi network by human TGN46
Lujan P, Garcia-Cabau C, Wakana Y, Lillo J, Rodilla-Ramírez C, Sugiura H, Malhotra V, Salvatella X, Garcia-Parajo M, Campelo F. Sorting of secretory proteins at the trans-Golgi network by human TGN46. ELife 2024, 12: rp91708. PMID: 38466628, PMCID: PMC10928510, DOI: 10.7554/elife.91708.Peer-Reviewed Original ResearchConceptsSecretory proteinsSorting of secretory proteinsCargo-sorting functionsTrans-Golgi networkNascent carriersCargo sortingLumenal domainMutagenesis approachTGN46Quantitative fluorescence microscopyCellular functionsMolecular playersTGNTransport carriersProteinFluorescence microscopyMembrane carrierSorting functionFundamental processesSortingCargoMutagenesisExportPAUFReceptorsSorting of secretory proteins at the trans-Golgi network by human TGN46
Lujan P, Garcia-Cabau C, Wakana Y, Vera Lillo J, Rodilla-Ramírez C, Sugiura H, Malhotra V, Salvatella X, Garcia-Parajo M, Campelo F. Sorting of secretory proteins at the trans-Golgi network by human TGN46. ELife 2024, 12 DOI: 10.7554/elife.91708.3.Peer-Reviewed Original ResearchTrans Golgi networkSecretory proteinsSorting of secretory proteinsCargo-sorting functionsTrans-Golgi networkNascent carriersCargo sortingGolgi networkLumenal domainMutagenesis approachTGN46Quantitative fluorescence microscopyCellular functionsMolecular playersTransport carriersProteinFluorescence microscopyMembrane carrierSorting functionFundamental processesSortingCargoMutagenesisExportPAUF
2021
Nodal modulator (NOMO) is required to sustain endoplasmic reticulum morphology
Amaya C, Cameron C, Devarkar SC, Seager S, Gerstein MB, Xiong Y, Schlieker C. Nodal modulator (NOMO) is required to sustain endoplasmic reticulum morphology. Journal Of Biological Chemistry 2021, 297: 100937. PMID: 34224731, PMCID: PMC8327139, DOI: 10.1016/j.jbc.2021.100937.Peer-Reviewed Original ResearchConceptsEndoplasmic reticulumER structural integrityGenetic epistasis analysisMembrane-bound organellesP62/sequestosome 1Endoplasmic reticulum morphologyImmunoglobulin-like domainsProtein light chain 3Light chain 3Epistasis analysisIdentical orthologsProteomic screenER morphologyHuman genomeMolecular playersNOMO1Protein foldingSequestosome 1Unknown functionER networkChain 3Lipid synthesisProper functionProtein 1OrthologsSynaptic recognition molecules in development and disease
Chowdhury D, Watters K, Biederer T. Synaptic recognition molecules in development and disease. Current Topics In Developmental Biology 2021, 142: 319-370. PMID: 33706921, PMCID: PMC8632550, DOI: 10.1016/bs.ctdb.2020.12.009.ChaptersConceptsSingle-cell expression studiesRecognition moleculesRecognition factorsKey protein familiesPost-translational modificationsLeucine-rich repeatsCell expression studiesSemaphorin/PlexinAlternative splicingProtein familyProteomic approachCombinatorial actionMolecular playersPartner recognitionExpression studiesMolecular themesSpecific expressionDisease relevanceSynapse specificationVertebrate brainImmunoglobulin SuperfamilyRich repertoireAppropriate brain regionsNeuron type-specific expressionSynaptic wiring
2018
RNA tales – how embryos read and discard messages from mom
Despic V, Neugebauer KM. RNA tales – how embryos read and discard messages from mom. Journal Of Cell Science 2018, 131: jcs201996. PMID: 29467249, DOI: 10.1242/jcs.201996.Peer-Reviewed Original ResearchConceptsZygotic genomePost-transcriptional regulatory pathwaysMaternal mRNA clearanceMaternal mRNA degradationEarly developmentContribution of microRNAsZygotic transitionMRNA clearanceRNA regulationMRNA decayCellular contextHigh-throughput methodZebrafish embryosFemale gametesMaternal mRNAsMolecular playersMRNA degradationRNA modificationsMolecular principlesRegulatory pathwaysGenomeLater stepsMZTSilent genomeEmbryos
2010
Evidence for intestinal chloride secretion
Murek M, Kopic S, Geibel J. Evidence for intestinal chloride secretion. Quarterly Journal Of Experimental Physiology And Cognate Medical Sciences 2010, 95: 471-478. PMID: 20233891, DOI: 10.1113/expphysiol.2009.049445.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsChloride ChannelsChloridesCLC-2 Chloride ChannelsCystic Fibrosis Transmembrane Conductance RegulatorDiarrheaEnterocytesHumansIntestinal AbsorptionIntestinal MucosaIntestinal SecretionsPotassium ChannelsSodium-Potassium-Chloride SymportersSodium-Potassium-Exchanging ATPaseTight JunctionsWater-Electrolyte Balance
2009
DNA excision repair proteins and Gadd45 as molecular players for active DNA demethylation
Ma D, Guo J, Ming G, Song H. DNA excision repair proteins and Gadd45 as molecular players for active DNA demethylation. Cell Cycle 2009, 8: 1526-1531. PMID: 19377292, PMCID: PMC2738863, DOI: 10.4161/cc.8.10.8500.Peer-Reviewed Original ResearchConceptsActive DNA demethylationDNA demethylationProcess of DNA demethylationMolecular playersProcess of DNA methylationHeritable gene silencingDNA cytosine methylationClass of methyltransferasesDNA demethylation mechanismTransgenerational epigenetic inheritanceDNA excision repair proteinNucleotide-excision repairExcision repair proteinsHeterochromatin formationCytosine methylationExcision repair enzymesEpigenetic inheritanceEvolutionary implicationsDNA methylationGene silencingModification signalsEnzymatic machineryDemethylation mechanismRepair enzymesRepair proteins
2007
ALTERED ENDOMETRIAL GENE EXPRESSION IN A BABOON MODEL OF ENDOMETRIOSIS
bas A, Hastings J, Jackson K, Giudice L, Kim J, Taylor H, Zhang X, Ho S. ALTERED ENDOMETRIAL GENE EXPRESSION IN A BABOON MODEL OF ENDOMETRIOSIS. Biology Of Reproduction 2007, 77: 71-72. DOI: 10.1093/biolreprod/77.s1.71b.Peer-Reviewed Original ResearchGene expressionEutopic endometriumEndometriosis modelEndometriotic samplesStromal cellsDifferential gene expressionP actionNon-human primate modelSteroid receptor distributionChronic pelvic painLevel of genesWindow of implantationLevel of methylationWindow of receptivityConsecutive menstrual cyclesEndometrial gene expressionInduction of diseaseGlandular epithelial cellsBisulfite sequencingMolecular playersEpigenetic changesTransient dysregulationPelvic painEndometrial morphologyProgesterone resistance
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