2025
Sustained Effectiveness, Tolerability, and Safety of Long-Term Prophylaxis with Lanadelumab in Hereditary Angioedema: The Prospective, Phase 4, Noninterventional EMPOWER Real-World Study
Bernstein J, Betschel S, Busse P, Banerji A, Wedner H, Manning M, Zaragoza-Urdaz R, Anderson J, Gagnon R, Baptist A, Soteres D, Lumry W, Craig T, Petroni D, Hsu F, Nova Estepan D, Juethner S, Watt M, Khutoryansky N, Zuraw B. Sustained Effectiveness, Tolerability, and Safety of Long-Term Prophylaxis with Lanadelumab in Hereditary Angioedema: The Prospective, Phase 4, Noninterventional EMPOWER Real-World Study. Advances In Therapy 2025, 1-20. DOI: 10.1007/s12325-025-03226-3.Peer-Reviewed Original ResearchTreatment-emergent adverse eventsLong-term prophylaxisHereditary angioedemaHAE attack ratesPost-baseline safety assessmentProphylaxis of hereditary angioedemaConclusionReal-world dataInjection site reactionsAttack rateReal-world studyYears of ageFemale patientsLanadelumabSite reactionsAdverse eventsFollow-upSafety signalsSafety dataEMPOWER studyPatientsDeficiency typeAngioedemaLow attack rateSustained effectPost-baseline
2023
0326 Symptom trajectories in adults with stable heart failure and insomnia: Evidence from a randomized controlled trial of CBT-I
Conley S, Jeon S, Wang Z, Tocchi C, Linsky S, O'Connell M, Redeker N. 0326 Symptom trajectories in adults with stable heart failure and insomnia: Evidence from a randomized controlled trial of CBT-I. Sleep 2023, 46: a145-a145. DOI: 10.1093/sleep/zsad077.0326.Peer-Reviewed Original ResearchHeart failureSelf-management educationSymptom trajectoriesDaytime symptomsStable chronic heart failureCBT-I groupChronic heart failureStable heart failureTrial of CBTCognitive behavioral therapyGroup-based trajectory modelingConclusions Most participantsSymptom improvementDaytime sleepinessBaseline fatigueRetrospective analysisHigher oddsIndividual symptomsSymptom profilesPhysical symptomsSustained effectPsychological symptomsSymptomsSymptom clustersBehavioral therapy
2022
The neural basis of psychedelic action
Kwan A, Olson D, Preller K, Roth B. The neural basis of psychedelic action. Nature Neuroscience 2022, 25: 1407-1419. PMID: 36280799, PMCID: PMC9641582, DOI: 10.1038/s41593-022-01177-4.Peer-Reviewed Original ResearchConceptsSerotonin 2A receptor agonistThalamocortical functional connectivityDownstream molecular signaling pathwaysDrug discoveryMolecular signaling pathwaysReceptor agonistSerotonin receptorsAssociation cortexPsychedelic actionSustained effectSubcortical regionsBasic neurobiologyFunctional connectivityTranscriptional changesPsychoactive moleculesSignaling pathwaysNeural mechanismsStructural plasticityNeural basisPsychedelic drugsChemistryPsychedelicsEnduring effectMoleculesAgonistsSex-specific impact of diabetes on all-cause mortality among adults with acute myocardial infarction: An updated systematic review and meta-analysis, 1988-2021
Ding Q, Funk M, Spatz ES, Lin H, Batten J, Wu E, Whittemore R. Sex-specific impact of diabetes on all-cause mortality among adults with acute myocardial infarction: An updated systematic review and meta-analysis, 1988-2021. Frontiers In Endocrinology 2022, 13: 918095. PMID: 36060979, PMCID: PMC9428712, DOI: 10.3389/fendo.2022.918095.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionCause mortalityRisk ratioDiabetes statusMyocardial infarctionSystematic reviewRandom-effects meta-analysis modelEffects meta-analysis modelPatients' diabetes statusLong-term mortalityPrevalence of diabetesCause mortality riskImpact of diabetesSex-specific analysesMeta-analysis modelSex-specific impactAMI survivorsUnadjusted analysesEligible studiesAMI treatmentInclusion criteriaMortality riskHigh riskDiabetesSustained effect
2017
The Cumulative Effects of Predictability on Synaptic Gain in the Auditory Processing Stream
Auksztulewicz R, Barascud N, Cooray G, Nobre A, Chait M, Friston K. The Cumulative Effects of Predictability on Synaptic Gain in the Auditory Processing Stream. Journal Of Neuroscience 2017, 37: 6751-6760. PMID: 28607165, PMCID: PMC5508257, DOI: 10.1523/jneurosci.0291-17.2017.Peer-Reviewed Original ResearchConceptsMagnetic field amplitudeField amplitudeAuditory processing streamSynaptic gainHealthy human volunteersSustained effectCross-spectral densityDynamic causal modelingSlow modulationSynaptic efficacyNeural gain modulationSlow fluctuationsBrain activityModel-based parametersHuman volunteersAuditory cortexModulation of synaptic gainGain modulationGamma activityProcess streamsModulation of brain activityPredictability of stimuliInduced activationEffects of predictabilitySource-level analysis
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