2025
Significantly higher incidence of circulating fatty objects in portal blood samples compared to peripheral blood samples in patients with pancreatic ductal adenocarcinoma
Wang R, Park K, Gaddam S, Liu Q, Watson R, Lim A, Ou Y, Zhang Y, Edderkaoui M, Lewis M, Lo S, Pandol S. Significantly higher incidence of circulating fatty objects in portal blood samples compared to peripheral blood samples in patients with pancreatic ductal adenocarcinoma. Frontiers In Oncology 2025, 15: 1611872. PMID: 40963865, PMCID: PMC12436445, DOI: 10.3389/fonc.2025.1611872.Peer-Reviewed Original ResearchPancreatic ductal adenocarcinomaPeripheral blood samplesPortal blood samplesBlood samplesDuctal adenocarcinomaEndoscopic ultrasound-guided fine-needle aspirationUltrasound-guided fine-needle aspirationPortal samplingFine-needle aspirationPortal vein samplingBlood cell fractionsSystem abnormalitiesClinical cancerPortal veinCancer patientsPeripheral samplesVascular occlusionVein samplingCFosVessel embolizationBile lipidsPatientsAdenocarcinomaParallel studiesBileA multi-center study of symptoms in patients with esophageal cancer postoperatively: A networking analysis
Chen F, Shen Z, Xiong Y, Jiang Y, Zhou D, Guo J, Huang H, Knobf M, Ye Z. A multi-center study of symptoms in patients with esophageal cancer postoperatively: A networking analysis. European Journal Of Oncology Nursing 2025, 74: 102784. PMID: 39813978, DOI: 10.1016/j.ejon.2025.102784.Peer-Reviewed Original ResearchConceptsEsophageal cancerSymptom clustersDry mouthEating difficultiesCross-sectional surveyStudy of symptomsExploratory factor analysisSymptom burdenMulti-center studyBridge symptomsWeeks post-surgeryAcid indigestionPost-surgerySentinel symptomPatientsCancerMultiple centersSymptomsFactor analysisHeartburnCore symptomsBileWeeksCluster levelMouth
2023
THU142 One-year Change In Bile Acids And Its Association With Changes In Metabolic Profile After Sleeve Gastrectomy In Youth
Tuli S, Kaur S, Bredella M, Misra M, Singhal V. THU142 One-year Change In Bile Acids And Its Association With Changes In Metabolic Profile After Sleeve Gastrectomy In Youth. Journal Of The Endocrine Society 2023, 7: bvad114.1394. PMCID: PMC10553406, DOI: 10.1210/jendso/bvad114.1394.Peer-Reviewed Original ResearchPhysiologically-Based Pharmacokinetic Modeling of Blood Clearance of Liver Fluorescent Markers for the Assessment of the Degree of Hepatic Ischemia-Reperfusion Injury *
Monti C, Audi S, Womack J, Hong S, Yang Y, Kim J, Dash R. Physiologically-Based Pharmacokinetic Modeling of Blood Clearance of Liver Fluorescent Markers for the Assessment of the Degree of Hepatic Ischemia-Reperfusion Injury *. Annual International Conference Of The IEEE Engineering In Medicine And Biology Society (EMBC) 2023, 00: 1-6. PMID: 38082711, DOI: 10.1109/embc40787.2023.10340273.Peer-Reviewed Original ResearchConceptsIschemia-reperfusion injuryMultidrug resistance-associated protein 2Hepatic ischemia-reperfusion injuryDegree of IRILiver transplantationBile-to-plasma ratioBlood clearanceEffects of ischemia-reperfusion injurySodium fluoresceinHepatic multidrug resistance-associated protein 2Bile-to-plasmaPhysiologically-based pharmacokinetic modelRat whole bloodRenal clearanceIschemia-reperfusionBile clearanceLiver uptakeClearanceProtein 2Whole bloodBilePBPK modelTransplantationLiverPhysiologically-basedPhysiologically-based pharmacokinetic (PBPK) modeling of sodium fluorescein (SF) blood clearance for assessing hepatic ischemia-reperfusion injury (IRI)
Monti C, Womack J, Audi S, Hong S, Yang Y, Kim J, Dash R. Physiologically-based pharmacokinetic (PBPK) modeling of sodium fluorescein (SF) blood clearance for assessing hepatic ischemia-reperfusion injury (IRI). Physiology 2023, 38: 5732857. DOI: 10.1152/physiol.2023.38.s1.5732857.Peer-Reviewed Original ResearchIschemia-reperfusion injuryIschemia-reperfusion injury conditionsMRP2 activityBlood clearanceSodium fluoresceinPBPK modelSF concentrationsEffects of ischemia-reperfusion injuryContribution of Mrp2Hepatic ischemia-reperfusion injuryWarm ischemia timeActivity of MRP2Bile-to-plasmaDiminished secretionIschemia timeMRP2 transportersCanalicular transportersLiver functionMRP2Intracellular internalizationBloodBileClearance dataClearanceLiver
2022
Fluorescein clearance kinetics in blood and bile indicates hepatic ischemia-reperfusion injury in rats
Kim J, Yang Y, Hong S, Zielonka J, Dash R, Audi S, Kumar S, Joshi A, Zimmerman M, Hong J. Fluorescein clearance kinetics in blood and bile indicates hepatic ischemia-reperfusion injury in rats. AJP Gastrointestinal And Liver Physiology 2022, 323: g126-g133. PMID: 35700191, DOI: 10.1152/ajpgi.00038.2022.Peer-Reviewed Original ResearchConceptsWarm ischemia timeHepatic ischemia-reperfusion injuryIschemia-reperfusion injuryBile-to-plasmaClearance kineticsWarm ischemia time groupsSprague-Dawley ratsBile metabolismMeasured 1 hSodium fluorescein injectionFluorescein injectionIschemia timeLiver functionTherapeutic strategiesSodium fluoresceinInverse correlationDecreased levelsBloodBileBile samplesFluorescence ratioReperfusionRatsFluoresceinIncreased levels
2021
Bile Microbiota in Liver Transplantation: Proof of Concept Using Gene Amplification in a Heterogeneous Clinical Scenario
D'Amico F, Bertacco A, Finotti M, Di Renzo C, Rodriguez-Davalos MI, Gondolesi GE, Cillo U, Mulligan D, Geibel J. Bile Microbiota in Liver Transplantation: Proof of Concept Using Gene Amplification in a Heterogeneous Clinical Scenario. Frontiers In Surgery 2021, 8: 621525. PMID: 33796547, PMCID: PMC8009296, DOI: 10.3389/fsurg.2021.621525.Peer-Reviewed Original ResearchBile microbiotaLiver donorsBiliary tract diseaseCommon bile ductGene amplificationRibosomal RNA gene amplificationLiver recipientsLiver transplantationPediatric recipientsLiver proceduresBiliary tractBile ductRecipient patientsTract diseaseBile samplesHeterogeneous cohortClinical scenariosBileSterile wayPCR sequencingPatientsRecipientsMicrobiotaTransplantationGallbladder
2020
The in vivo preventive and therapeutic properties of curcumin in bile reflux‐related oncogenesis of the hypopharynx
Doukas SG, Doukas PG, Sasaki CT, Vageli D. The in vivo preventive and therapeutic properties of curcumin in bile reflux‐related oncogenesis of the hypopharynx. Journal Of Cellular And Molecular Medicine 2020, 24: 10311-10321. PMID: 32691972, PMCID: PMC7521262, DOI: 10.1111/jcmm.15640.Peer-Reviewed Original ResearchConceptsNF-κBRecent pre-clinical studiesHuman hypopharyngeal cellsIndependent risk factorPre-clinical studiesNF-κB activationTherapeutic propertiesHypopharyngeal cellsRisk factorsMolecular eventsHypopharyngeal mucosaBile exposureImmunohistochemical analysisFuture translational developmentBile acidsOncogenic profileHypopharynxCarcinogenic effectsOncogenic functionOverexpression of RelAEpithelial cellsBileTranslational developmentExpression of genesCurcuminThe Progressive Mutagenic Effects of Acidic Bile Refluxate in Hypopharyngeal Squamous Cell Carcinogenesis: New Insights
Sasaki CT, Doukas SG, Costa J, Vageli DP. The Progressive Mutagenic Effects of Acidic Bile Refluxate in Hypopharyngeal Squamous Cell Carcinogenesis: New Insights. Cancers 2020, 12: 1064. PMID: 32344873, PMCID: PMC7281001, DOI: 10.3390/cancers12051064.Peer-Reviewed Original ResearchAcidic bileUpper aerodigestive tractAdditional risk factorsBiomarkers of progressionSquamous cell carcinogenesisNF-κB activationNeck malignanciesAerodigestive tractInvasive cancerHistopathological changesRisk factorsHypopharyngeal mucosaEarly neoplasiaMalignant lesionsP53 expressionTranslational studiesVivo modelCell carcinogenesisBileExperimental modelEarly detectionCancerNovel evidenceMutagenic effectsFirst study
2019
Temporal characteristics of NF-κB inhibition in blocking bile-induced oncogenic molecular events in hypopharyngeal cells
Doukas PG, Vageli DP, Doukas SG, Sasaki CT. Temporal characteristics of NF-κB inhibition in blocking bile-induced oncogenic molecular events in hypopharyngeal cells. Oncotarget 2019, 10: 3339-3351. PMID: 31164956, PMCID: PMC6534360, DOI: 10.18632/oncotarget.26917.Peer-Reviewed Original ResearchAcidic bileNF-κB inhibitorBAY 11Hypopharyngeal cellsIL-6MiR-155MiR-375Specific NF-κB inhibitorMiR-21NF-κB inhibitionPre-neoplastic eventsEsophageal refluxLaryngopharyngeal cancerRisk factorsMolecular eventsEarly neoplasiaTherapeutic implicationsMiR-192MiR-451aClinical useWestern blotB activationBileOncogenic factorB inhibitorHepatic Inflammatory Pseudotumor: An Important Differential Diagnosis in Patients With a History of Previous Biliary Procedures
Zhao J, Olino K, Low L, Qiu S, Stevenson H. Hepatic Inflammatory Pseudotumor: An Important Differential Diagnosis in Patients With a History of Previous Biliary Procedures. ACG Case Reports Journal 2019, 6: e00015. PMID: 31598534, PMCID: PMC6657982, DOI: 10.14309/crj.0000000000000015.Peer-Reviewed Original ResearchHepatic inflammatory pseudotumorInflammatory pseudotumorBile duct stent placementTreated with antibioticsHepatic abscess formationTriggers of liver inflammationRare lesionsBile leakageBiliary drainageBiliary proceduresAbscess formationStent placementComplete resolutionSurgical interventionDifferential diagnosisFollow-upLiver inflammationPatientsMalignancyDiagnosisBilePseudotumorRecurrencePathophysiologyInflammation
2018
Pancreatic-Type Mixed Acinar Neuroendocrine Carcinoma Arising in the Common Bile Duct: A Case Report
Shafique K, Lee L, Samad A, Wang L, Klimstra D. Pancreatic-Type Mixed Acinar Neuroendocrine Carcinoma Arising in the Common Bile Duct: A Case Report. Advances In Anatomic Pathology 2018, 23: 266-270. DOI: 10.1097/pcr.0000000000000278.Peer-Reviewed Original ResearchMixed acinar-neuroendocrine carcinomaAcinar-neuroendocrine carcinomaBile ductNeuroendocrine carcinomaPancreatic heterotopiaHigh-power fieldsExtrahepatic bile ductNeuroendocrine neoplasmsGranular chromatinProminent nucleoliAbdominal discomfortCase reportMalignant transformationSolid massExtrapancreatic locationImaging studiesMinimal to moderate amountsSolid sheetsPancreatic typeBileCarcinomaTumorImmunohistochemistryDuctHeterotopia
2017
Studies on the mechanisms of bile acid initiated hepatic inflammation in cholestatic liver injury.
Cai SY, Boyer JL. Studies on the mechanisms of bile acid initiated hepatic inflammation in cholestatic liver injury. Inflammation And Cell Signaling 2017, 4 PMID: 28804737, PMCID: PMC5553904, DOI: 10.14800/ics.1561.Peer-Reviewed Original Research
2015
Signaling pathways in biliary epithelial cells
Leite M, Guerra M, Andrade V, Nathanson M. Signaling pathways in biliary epithelial cells. 2015, 15-33. DOI: 10.1002/9781118663387.ch2.Peer-Reviewed Original ResearchBiliary epithelial cellsEpithelial cellsFormation of bileSurface membrane receptorsBiliary treeDuctal bileIntracellular signal transduction pathwaysCanalicular bileGrowth factorCholangiocytesBileCell functionPeptide hormonesBile saltsDetoxification of xenobioticsMembrane receptorsSignal transduction pathwaysTransduction pathways
2009
Signaling Pathways in Biliary Epithelial Cells
Leite M, Andrade V, Nathanson M. Signaling Pathways in Biliary Epithelial Cells. 2009, 25-39. DOI: 10.1007/978-3-642-00150-5_2.Peer-Reviewed Original ResearchBiliary epithelial cellsEpithelial cellsFormation of bileSurface membrane receptorsBiliary treeDuctal bileIntracellular signal transduction pathwaysCanalicular bileGrowth factorCholangiocytesBileCell functionPeptide hormonesBile saltsDetoxification of xenobioticsMembrane receptorsSignal transduction pathwaysTransduction pathways
2008
Functional Anatomy of Normal Bile Ducts
Strazzabosco M, Fabris L. Functional Anatomy of Normal Bile Ducts. The Anatomical Record 2008, 291: 653-660. PMID: 18484611, PMCID: PMC3743051, DOI: 10.1002/ar.20664.Peer-Reviewed Original ResearchConceptsBile ductBiliary treeExtrahepatic bile ductSmall bile ductsNormal bile ductsLiver progenitor cellsBile productionBiliary epitheliumMajor ductsSecretory functionVascular structuresProgenitor cellsCholangiocyte functionFunctional anatomyBileDuctCholangiocytesIntestineFunctional interactionMorphological heterogeneityNerveGallbladderVariety of functionsEpithelium
2001
Stimulation of ATP secretion in the liver by therapeutic bile acids
NATHANSON M, BURGSTAHLER A, MASYUK A, LaRUSSO N. Stimulation of ATP secretion in the liver by therapeutic bile acids. Biochemical Journal 2001, 358: 1-5. DOI: 10.1042/bj3580001.Peer-Reviewed Original ResearchBile duct epitheliumUrsodeoxycholic acidBile acidsSecretory disordersATP receptorsPerfusion of ATPBile duct segmentsEndogenous ATPTherapeutic bile acidsSecretion of ATPNumber of disordersMechanism of actionBile flowPharmacological activationPharmacological meansTherapeutic benefitElectrolyte secretionDelivery of ATPATP secretionCystic fibrosisOnly agentATP releaseBileCytosolic Ca2Liver
1999
Biliary bile acids in primary biliary cirrhosis: Effect of ursodeoxycholic acid
Combes B, Carithers R, Maddrey W, Munoz S, Garcia‐Tsao G, Bonner G, Boyer J, Luketic V, Shiffman M, Peters M, White H, Zetterman R, Risser R, Rossi S, Hofmann A. Biliary bile acids in primary biliary cirrhosis: Effect of ursodeoxycholic acid. Hepatology 1999, 29: 1649-1654. PMID: 10347103, PMCID: PMC4004074, DOI: 10.1002/hep.510290618.Peer-Reviewed Original ResearchMeSH KeywordsBileBile Acids and SaltsChenodeoxycholic AcidCholic AcidChromatography, GasChromatography, High Pressure LiquidDeoxycholic AcidDouble-Blind MethodDrug Administration ScheduleFemaleHumansLithocholic AcidLiver Cirrhosis, BiliaryMaleMiddle AgedPlacebosRegression AnalysisReproducibility of ResultsTime FactorsUrsodeoxycholic AcidConceptsPrimary biliary cirrhosisBile acid compositionUrsodeoxycholic acidBile acidsBiliary cirrhosisSeverity of PBCSingle bedtime dosePlacebo-controlled trialBiliary bile acidsEndogenous bile acidsMajor bile acidsBedtime dosePlacebo medicationDuodenal bileHigh-pressure liquid chromatography methodPatientsNormal personsBileSignificant decreaseCirrhosisAcid compositionCDCATaurineLiquid chromatography methodYears
1997
Enterohepatic circulation of scymnol sulfate in an elasmobranch, the little skate (Raja erinacea)
Fricker G, Wössner R, Drewe J, Fricker R, Boyer J. Enterohepatic circulation of scymnol sulfate in an elasmobranch, the little skate (Raja erinacea). American Journal Of Physiology 1997, 273: g1023-g1030. PMID: 9374698, DOI: 10.1152/ajpgi.1997.273.5.g1023.Peer-Reviewed Original ResearchConceptsEnterohepatic circulationScymnol sulfateBile alcohol sulfatesBile flowBiliary secretionCholeretic effectMajor bile saltsHepatic uptakeHepatic eliminationIntestinal epitheliumBileLiverSkate liverHepatic transportSpecific transport mechanismsBile alcoholsMajor metaboliteFirst direct demonstrationBile saltsCholyltaurinePerfusateLittle skatePolar metabolitesCompetitive mannerDirect demonstrationViral RNA in duodenal bile of cirrhotic patients with chronic hepatitis C.
Kuan S, Garcia-Tsao G, Cartun R, Emanuel J, West A. Viral RNA in duodenal bile of cirrhotic patients with chronic hepatitis C. Archives Of Pathology & Laboratory Medicine 1997, 121: 847-52. PMID: 9278613.Peer-Reviewed Original ResearchConceptsHepatitis C virusCirrhotic patientsDuodenal bileChronic hepatitis C virusHepatitis C virus RNAHCV-negative controlsChronic hepatitis C.C virus RNAReverse transcriptase-polymerase chain reactionViral RNATranscriptase-polymerase chain reactionCross-reacting antigenSeropositive patientsHepatitis C.Seronegative controlsEndoscopic evaluationBreast milkC virusPolymerase chain reactionCirrhotic liverC100 proteinAntigen immunoreactivePatientsBileVirus RNA
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