2024
Metabolic regulator LKB1 controls adipose tissue ILC2 PD-1 expression and mitochondrial homeostasis to prevent insulin resistance
Sun J, Zhang Y, Zhang Q, Hu L, Zhao L, Wang H, Yuan Y, Niu H, Wang D, Zhang H, Liu J, Feng X, Su X, Qiu J, Sun J, Xu H, Zhang C, Wang K, Bi Y, Engleman E, Shen L. Metabolic regulator LKB1 controls adipose tissue ILC2 PD-1 expression and mitochondrial homeostasis to prevent insulin resistance. Immunity 2024, 57: 1289-1305.e9. PMID: 38772366, DOI: 10.1016/j.immuni.2024.04.024.Peer-Reviewed Original ResearchLiver kinase B1PD-1 expressionLKB1 deficiencyInsulin resistanceSuppressing Bcl-xL expressionBcl-xL expressionGroup 2 innate lymphoid cellsBlockade of PD-1Treatment of metabolic diseasesObesity-induced insulin resistanceFunction of ILC2sType 2 immunityMitochondrial homeostasisActivation of NFATObesity-associated insulin resistanceMitochondrial metabolismPrevent insulin resistanceKinase B1Exacerbate insulin resistanceEnhanced mitophagyMetabolic homeostasisILC2 responsesPD-1Genetic ablationLymphoid cells
2019
Anti‐inflammatory effects of oestrogen mediate the sexual dimorphic response to lipid‐induced insulin resistance
Camporez JP, Lyu K, Goldberg EL, Zhang D, Cline GW, Jurczak MJ, Dixit VD, Petersen KF, Shulman GI. Anti‐inflammatory effects of oestrogen mediate the sexual dimorphic response to lipid‐induced insulin resistance. The Journal Of Physiology 2019, 597: 3885-3903. PMID: 31206703, PMCID: PMC6876753, DOI: 10.1113/jp277270.Peer-Reviewed Original ResearchConceptsObesity-induced insulin resistanceHigh-fat dietEctopic lipid contentWhite adipose tissue lipolysisInsulin resistanceAdipose tissue lipolysisMale miceInsulin sensitivityFemale miceInsulin-stimulated suppressionWAT inflammationTissue lipolysisRodent studiesTumor necrosis factor αWhole-body insulin sensitivityLipid-induced insulin resistanceMetabolic homeostasisAge-matched menInterleukin-6 concentrationsSkeletal muscleAnti-inflammatory effectsType 2 diabetesInsulin-mediated suppressionSexual dimorphic responseNecrosis factor α
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