2019
Association of metformin, sulfonylurea and insulin use with brain structure and function and risk of dementia and Alzheimer’s disease: Pooled analysis from 5 cohorts
Weinstein G, Davis-Plourde KL, Conner S, Himali JJ, Beiser AS, Lee A, Rawlings AM, Sedaghat S, Ding J, Moshier E, van Duijn CM, Beeri MS, Selvin E, Ikram MA, Launer LJ, Haan MN, Seshadri S. Association of metformin, sulfonylurea and insulin use with brain structure and function and risk of dementia and Alzheimer’s disease: Pooled analysis from 5 cohorts. PLOS ONE 2019, 14: e0212293. PMID: 30768625, PMCID: PMC6377188, DOI: 10.1371/journal.pone.0212293.Peer-Reviewed Original ResearchConceptsInsulin useMRI measuresDementia/AD riskCognitive functionAssociation of metforminGlycemic control propertiesNew-onset dementiaSacramento Area Latino StudyCox regression analysisBrain MRI measuresPopulation-based cohortRisk of dementiaAdverse cognitive outcomesLife style changesGlobal cognitive functionFramingham Heart StudySulfonylurea useDiabetes medicationsReykjavik StudyGlycemic dysregulationRenal functionGlycemic controlRotterdam StudyDementia riskIncident dementia
2018
Among Children Born Extremely Preterm a Higher Level of Circulating Neurotrophins Is Associated with Lower Risk of Cognitive Impairment at School Age
Kuban K, Heeren T, O'Shea T, Joseph R, Fichorova R, Douglass L, Jara H, Frazier J, Hirtz D, Taylor H, Rollins J, Paneth N, Investigators E, Ware J, Coster T, Hanson B, Wilson R, McGhee K, Lee P, Asgarian A, Sadhwani A, Perrin E, Neger E, Mattern K, Walkowiak J, Barron S, Shah B, Singh R, Smith A, Klein D, McQuiston S, Venuti L, Powers B, Foley A, Dessureau B, Wood M, Damon-Minow J, Ehrenkranz R, Benjamin J, Romano E, Tsatsanis K, Chawarska K, Kim S, Dieterich S, Bearrs K, Peters N, Brown P, Ansusinha E, Waldrep E, Friedman J, Hounshell G, Allred D, Engelke S, Darden-Saad N, Stainback G, Warner D, Wereszczak J, Bernhardt J, McKeeman J, Meyer E, Pastyrnak S, Rathbun J, Nota S, Crumb T, Lenski M, Weiland D, Lloyd M, Hunter S, Msall M, Ramoskaite R, Wiggins S, Washington K, Martin R, Prendergast B, Scott M, Klarr J, Kring B, DeRidder J, Vogt K, Yamamoto H, Ryan S, Junaid D, Dawood H, Beatty N, Luu N, Tang V, Sassi R, Pasicznyk J. Among Children Born Extremely Preterm a Higher Level of Circulating Neurotrophins Is Associated with Lower Risk of Cognitive Impairment at School Age. The Journal Of Pediatrics 2018, 201: 40-48.e4. PMID: 30029870, PMCID: PMC6684153, DOI: 10.1016/j.jpeds.2018.05.021.Peer-Reviewed Original ResearchConceptsWeeks of lifeNeurotrophic proteinsSevere cognitive impairmentBlood levelsCognitive impairmentInflammatory proteinLower riskBrain-derived neurotrophic factorNeonatal blood specimensProtein blood levelsHigh blood levelsAdverse cognitive outcomesElevated blood levelsLow Gestational Age Newborn StudyNormal T cellsYears of ageHigh exposureFunction testsNeurotrophic factorCognitive function levelT cellsReduced riskMultinomial logistic regressionElevated proteinBlood specimens
2002
Relationship between Alcohol Consumption and Folstein Mini-Mental Status Examination Scores among Older Cognitively Impaired Adults
Reid MC, Maciejewski PK, Hawkins KA, Bogardus ST. Relationship between Alcohol Consumption and Folstein Mini-Mental Status Examination Scores among Older Cognitively Impaired Adults. Journal Of Geriatric Psychiatry And Neurology 2002, 15: 31-37. PMID: 11936241, DOI: 10.1177/089198870201500107.Peer-Reviewed Original ResearchConceptsAlcohol abuse/dependenceAbuse/dependenceCognitive screenMMSE subscoresLower total MMSE scoresMMSE scoresDistinctive cognitive profileCognitive impairmentBrief cognitive screenAdverse cognitive outcomesTotal MMSE scoreAlcohol historyCognitive measuresCognitive domainsCognitive profileAlcohol consumptionMini - mental status examination testMini-Mental Status Examination scoreCognitive outcomesAlcohol abuse/dependence disordersImpaired adultsCurrent alcohol intakeMiddle-aged adultsSignificant alcohol historyComprehensive geriatric assessment
1999
The Etiology and Outcome of Cerebral Ventriculomegaly at Term in Very Low Birth Weight Preterm Infants
Ment L, Vohr B, Allan W, Westerveld M, Katz K, Schneider K, Makuch R. The Etiology and Outcome of Cerebral Ventriculomegaly at Term in Very Low Birth Weight Preterm Infants. 1999, 104: 243-248. PMID: 10429002, DOI: 10.1542/peds.104.2.243.Peer-Reviewed Original ResearchConceptsBronchopulmonary dysplasiaPreterm infantsCorrected ageIndependent predictorsCerebral ventriculomegalyBirth weightGrade 3Low birth weight preterm infantsBirth weight preterm infantsMaternal educationLow birth weight survivorsCause of ventriculomegalyDevelopment of ventriculomegalyGrades of IVHIncidence of handicapWeight preterm infantsMonths' corrected ageAdverse neurodevelopmental outcomesLow birth weightYears' corrected ageAdverse cognitive outcomesLogistic regression analysisYears of ageApgar scoreNeurodevelopmental handicap
1996
Neurodevelopmental outcome at 36 months' corrected age of preterm infants in the Multicenter Indomethacin Intraventricular Hemorrhage Prevention Trial.
Ment L, Vohr B, Oh W, Scott D, Allan W, Westerveld M, Duncan C, Ehrenkranz R, Katz K, Schneider K, Makuch R. Neurodevelopmental outcome at 36 months' corrected age of preterm infants in the Multicenter Indomethacin Intraventricular Hemorrhage Prevention Trial. 1996, 98: 714-8. PMID: 8885951, DOI: 10.1542/peds.98.4.714.Peer-Reviewed Original ResearchMeSH KeywordsCerebral HemorrhageChild DevelopmentChild, PreschoolChi-Square DistributionCyclooxygenase InhibitorsHumansIndomethacinInfantInfant, NewbornInfant, PrematureInfant, Premature, DiseasesInfant, Very Low Birth WeightIntelligence TestsNeurologic ExaminationUltrasonography, Doppler, TranscranialConceptsLow-dose indomethacinMonths' corrected ageIntraventricular hemorrhageCorrected ageNeurodevelopmental followLong-term neurodevelopmental followLow birth weight infantsLow birth weight neonatesBirth weight infantsMean gestational ageBirth weight neonatesStandard neurologic examinationAdverse cognitive outcomesIncidence of deafnessDose indomethacinWeight infantsPreterm infantsProspective trialWeight neonatesCranial ultrasoundEarly administrationNeurodevelopmental outcomesNeurologic examinationCerebral palsyGestational age
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