2019
Bi-Functional Chicken Immunoglobulin-Like Receptors With a Single Extracellular Domain (ChIR-AB1): Potential Framework Genes Among a Relatively Stable Number of Genes Per Haplotype
Meziane E, Potts N, Viertlboeck B, Løvlie H, Krupa A, Burke T, Brown S, Watson K, Richardson D, Pizzari T, Göbel T, Kaufman J. Bi-Functional Chicken Immunoglobulin-Like Receptors With a Single Extracellular Domain (ChIR-AB1): Potential Framework Genes Among a Relatively Stable Number of Genes Per Haplotype. Frontiers In Immunology 2019, 10: 2222. PMID: 31620133, PMCID: PMC6760009, DOI: 10.3389/fimmu.2019.02222.Peer-Reviewed Original ResearchConceptsLeukocyte receptor complexRed junglefowlIg-like receptorsChicken Ig-like receptorsLeukocyte Ig-like receptorsCHIR-AB1Chicken linesExtracellular domainImmunoglobulin-like (Ig-likeHighly-related genesTrios of parentsExtracellular Ig-like domainsStrand-mediated conformational analysisIg-like domainsCommercial chicken linesPositively-charged residuesKiller Ig-like receptorsExperimental chicken linesCytoplasmic tailSequencing studiesIg-likeFramework genesTransmembrane regionSequence relationshipsEgg-laying chickens
2014
Structure, domain organization, and different conformational states of stem cell factor-induced intact KIT dimers
Opatowsky Y, Lax I, Tomé F, Bleichert F, Unger VM, Schlessinger J. Structure, domain organization, and different conformational states of stem cell factor-induced intact KIT dimers. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: 1772-1777. PMID: 24449920, PMCID: PMC3918759, DOI: 10.1073/pnas.1323254111.Peer-Reviewed Original ResearchConceptsExtracellular regionConformational statesIg-like domainsReceptor tyrosine kinasesDifferent conformational statesTrans autophosphorylationTyrosine kinase domainMembrane-proximal Ig-like domainsTrans phosphorylationAutophosphorylation sitesDomain organizationKinase domainCytoplasmic regionHomotypic interactionsKinase activityReceptor dimersDimeric receptorTyrosine kinaseAsymmetric arrangementMolecular interactionsPrevalent conformationsCrystal structureAutophosphorylationDimersKinase
2013
Crystal structure of glycoprotein E2 from bovine viral diarrhea virus
Li Y, Wang J, Kanai R, Modis Y. Crystal structure of glycoprotein E2 from bovine viral diarrhea virus. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 6805-6810. PMID: 23569276, PMCID: PMC3637714, DOI: 10.1073/pnas.1300524110.Peer-Reviewed Original ResearchConceptsBovine viral diarrhea virus (BVDV) E2C-terminal motifHost cell cytoplasmImportant animal pathogenMembrane fusion mechanismIg-like domainsUnique protein architectureOuter lipid envelopeProtein architectureAnimal pathogensFusion apparatusStructure of E2New foldCellular membranesBovine viral diarrhea virusAromatic residuesViral diarrhea virusCell cytoplasmLipid envelopeDisulfide bondsCell entryDiarrhea virusMajor global health threatCrystal structureFusion mechanism
2006
Crystal Structure of the Agrin-responsive Immunoglobulin-like Domains 1 and 2 of the Receptor Tyrosine Kinase MuSK
Stiegler A, Burden S, Hubbard S. Crystal Structure of the Agrin-responsive Immunoglobulin-like Domains 1 and 2 of the Receptor Tyrosine Kinase MuSK. Journal Of Molecular Biology 2006, 364: 424-433. PMID: 17011580, PMCID: PMC1752213, DOI: 10.1016/j.jmb.2006.09.019.Peer-Reviewed Original ResearchConceptsHydrophobic patchDisulfide bridgesReceptor tyrosine kinase MuSKUnique hydrophobic patchIg-like domainsNon-crystallographic dimerImmunoglobulin-like domains 1Heparan sulfate proteoglycansReceptor tyrosine kinasesAgrin responsivenessInternal disulfide bridgeMuSK activationDomain 1Tyrosine kinaseIg1MuSK ectodomainI-setBiochemical analysisSulfate proteoglycansBiochemical dataMuscle-specific kinaseKinaseCrystal structureNeuromuscular junctionSkeletal muscleSynCAM in Formation and Function of Synaptic Specializations
Biederer T. SynCAM in Formation and Function of Synaptic Specializations. 2006, 125-135. DOI: 10.1007/978-0-387-32562-0_9.Peer-Reviewed Original ResearchInteraction motifsSynCAM 1Short cytosolic tailProtein interaction motifsSingle transmembrane regionIg-like domainsCytosolic tailActin cytoskeletonTransmembrane regionIntracellular sequencesExtracellular sequencesAdaptor moleculeGeneral roleMembrane differentiationSynaptic differentiationCentral nervous systemPostsynaptic membraneAdhesion moleculesProteinSynaptic cleftMotifPresynaptic terminalsDifferentiationSequenceFamily members
1997
Kit Receptor Dimerization Is Driven by Bivalent Binding of Stem Cell Factor*
Lemmon M, Pinchasi D, Zhou M, Lax I, Schlessinger J. Kit Receptor Dimerization Is Driven by Bivalent Binding of Stem Cell Factor*. Journal Of Biological Chemistry 1997, 272: 6311-6317. PMID: 9045650, DOI: 10.1074/jbc.272.10.6311.Peer-Reviewed Original ResearchConceptsStem cell factorKIT dimerizationReceptor dimerizationExtracellular domainCell factorFourth Ig-like domainColony-stimulating factor-1Receptor tyrosine kinasesIg-like domainsCytokine stem cell factorDomain bindsPlatelet-derived growth factorGrowth factorLike domainDimer bindsMost growth factorsTyrosine kinaseDimerization siteConformational changesReceptor KITAnalytical ultracentrifugationForms of KITBivalent bindingFactor 1Dimerization
1994
Distinct developmental expression of a new avian fibroblast growth factor receptor
Marcelle C, Eichmann A, Halevy O, Bréant C, Le Douarin N. Distinct developmental expression of a new avian fibroblast growth factor receptor. Development 1994, 120: 683-694. PMID: 8162862, DOI: 10.1242/dev.120.3.683.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBase SequenceBlotting, NorthernChick EmbryoCloning, MolecularCoturnixFibroblast Growth Factor 2GastrulaGene ExpressionIn Situ HybridizationMolecular Sequence DataMusclesPolymerase Chain ReactionReceptor Protein-Tyrosine KinasesReceptor, Fibroblast Growth Factor, Type 4Receptors, Fibroblast Growth FactorConceptsFibroblast growth factor receptorGrowth factor receptorMesoderm-derived structuresSkeletal muscle lineageFibroblast growth factor receptor (FGFR) familySatellite cellsStage-specific mannerDistinct developmental expressionFactor receptorNew memberIg-like domainsEarly myotomeGrowth factor receptor familyPattern of expressionSkeletal muscleEmbryonic RNAPrimitive streak stageLateral epiblastMuscle lineageDays of developmentFactor receptor familyPrimary transcriptEarly avian developmentAvian developmentFibroblast growth factor
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