2022
Immune landscape of human placental villi using single-cell analysis
Toothaker JM, Olaloye O, McCourt BT, McCourt CC, Silva TN, Case RM, Liu P, Yimlamai D, Tseng G, Konnikova L. Immune landscape of human placental villi using single-cell analysis. Development 2022, 149 PMID: 35050308, PMCID: PMC8935213, DOI: 10.1242/dev.200013.Peer-Reviewed Original ResearchMeSH KeywordsAntigens, CDAntigens, Differentiation, MyelomonocyticB-LymphocytesB7-H1 AntigenChorionic VilliFemaleFetusFlow CytometryHLA-DR AntigensHumansKiller Cells, NaturalLeukocyte Common AntigensLymphocyte ActivationMacrophagesMemory T CellsPlacentaPregnancyPregnancy Trimester, SecondReceptors, Cell SurfaceReceptors, ChemokineSingle-Cell AnalysisT-LymphocytesConceptsT cellsHuman placental villiPlacental villiImmune systemFetal immune systemMaternal immune systemFetal immune cellsAdult T-cellT cell receptor stimulationCell receptor stimulationHealthy pregnancyImmune landscapeMemory phenotypeImmune cellsFetal organsEnhanced proliferative capacityReceptor stimulationMultiple subtypesPV tissueComplex immune systemImaging modalitiesMass cytometryProliferative capacityMaternal mechanismsRecent reports
2017
Membrane-bound Dickkopf-1 in Foxp3+ regulatory T cells suppresses T cell-mediated autoimmune colitis
Chae W, Hao L, Henegariu O, Yilmaz S, Bothwell A. Membrane-bound Dickkopf-1 in Foxp3+ regulatory T cells suppresses T cell-mediated autoimmune colitis. The Journal Of Immunology 2017, 198: 156.8-156.8. DOI: 10.4049/jimmunol.198.supp.156.8.Peer-Reviewed Original ResearchDKK-1 expressionDickkopf-1T cellsImmunological toleranceT cell-mediated toleranceEffector CD4 T cellsT cell-mediated colitisRegulatory T cellsCD4 T cellsT cell receptor stimulationCell receptor stimulationActivated TregsAutoimmune colitisTreg markersColitis modelReceptor stimulationTregsCanonical Wnt pathwayDe novo protein synthesisCell proliferationColitisWnt pathwayNovo protein synthesisMAPK pathwayWnt ligands
2010
An Oscillatory Switch in mTOR Kinase Activity Sets Regulatory T Cell Responsiveness
Procaccini C, De Rosa V, Galgani M, Abanni L, Calì G, Porcellini A, Carbone F, Fontana S, Horvath TL, La Cava A, Matarese G. An Oscillatory Switch in mTOR Kinase Activity Sets Regulatory T Cell Responsiveness. Immunity 2010, 33: 929-941. PMID: 21145759, PMCID: PMC3133602, DOI: 10.1016/j.immuni.2010.11.024.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCD4 AntigensCell ProliferationCells, CulturedClonal AnergyDisease ProgressionEncephalomyelitis, Autoimmune, ExperimentalForkhead Transcription FactorsHumansInterleukin-2Interleukin-2 Receptor alpha SubunitLeptinMiceMice, Inbred C57BLSignal TransductionSirolimusT-Lymphocytes, RegulatoryTOR Serine-Threonine KinasesConceptsTreg cellsAnergic stateInterleukin-2Treg cell expansionRegulatory T cellsExogenous interleukin-2T cell responsivenessCell receptor stimulationImmune toleranceT cellsCell responsivenessReceptor stimulationMTOR activationEarly downregulationMammalian targetMTOR kinase activityRapamycin (mTOR) pathwayProliferative capabilityTransient inhibitionUnderlying mechanismElevated activityEnergy metabolismCellsResponsivenessCell expansionMechanisms of Pre-B Cell Receptor-Inactivation In Acute Lymphoblastic Leukemia
Duy C, Nowak D, Klemm L, Nahar R, Ng C, Elliott E, Hofmann W, Heisterkamp N, Lowell C, Koeffler P, Muschen M. Mechanisms of Pre-B Cell Receptor-Inactivation In Acute Lymphoblastic Leukemia. Blood 2010, 116: 147. DOI: 10.1182/blood.v116.21.147.147.Peer-Reviewed Original ResearchPre-B cell receptorImmunoglobulin μ chainCell receptor functionCell receptor stimulationTyrosine kinasePAX5 fusion genesSystematic gene expression analysisΜ chainsSplice variantsCell receptorRapid cell cycle arrestExon 16Immunoglobulin gene rearrangementsReceptor functionReceptor signal transductionPre-B cell receptor functionGene rearrangementsGene expression analysisLeukemia cellsDominant-negative waySyk tyrosine kinaseCell cycle arrestPre B cellsSH2 domainMRNA splicing
2009
Alterations in the Kinetics of CD4+ T Cell Responses with Aging
Hong M, Dan J, Lee W, Kang I. Alterations in the Kinetics of CD4+ T Cell Responses with Aging. Journal Of Rheumatic Diseases 2009, 16: 271-280. DOI: 10.4078/jkra.2009.16.4.271.Peer-Reviewed Original ResearchKinetics of CD4T cell proliferationHr of stimulationT cell activationT cellsCD40L expressionCell proliferationCell activationPeripheral blood mononuclear cellsT cell immunityT cell responsesAnti-CD28 antibodiesBlood mononuclear cellsActivation marker CD69Duration of stimulationRisk of infectionT cell receptor stimulationAge-associated changesCell receptor stimulationYounger patientsCell immunityCD25 expressionMononuclear cellsElderly subjectsCD4
2006
Expression of Interleukin-10 in Intestinal Lymphocytes Detected by an Interleukin-10 Reporter Knockin tiger Mouse
Kamanaka M, Kim ST, Wan YY, Sutterwala FS, Lara-Tejero M, Galán JE, Harhaj E, Flavell RA. Expression of Interleukin-10 in Intestinal Lymphocytes Detected by an Interleukin-10 Reporter Knockin tiger Mouse. Immunity 2006, 25: 941-952. PMID: 17137799, DOI: 10.1016/j.immuni.2006.09.013.Peer-Reviewed Original ResearchConceptsIntraepithelial lymphocytesInterleukin-10T cellsColonic lamina propria lymphocytesIL-10 protein expressionIL-10-producing T cellsSmall intestinal intraepithelial lymphocytesLamina propria lymphocytesRegulatory T cellsIntestinal intraepithelial lymphocytesAnti-CD3 treatmentIL-10 geneRegulation of inflammationRegulatory cells 1T cell receptor stimulationCell receptor stimulationIntestinal lymphocytesIL-10Receptor stimulationSmall intestineKnockin miceLymphocytesCells 1Protein expressionStrong expression
2005
Requirement of Voltage-Gated Calcium Channel ß4 Subunit for T Lymphocyte Functions
Badou A, Basavappa S, Desai R, Peng YQ, Matza D, Mehal WZ, Kaczmarek LK, Boulpaep EL, Flavell RA. Requirement of Voltage-Gated Calcium Channel ß4 Subunit for T Lymphocyte Functions. Science 2005, 307: 117-121. PMID: 15637280, DOI: 10.1126/science.1100582.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCalciumCalcium Channels, L-TypeCalcium SignalingCD4-Positive T-LymphocytesCytokinesDNA-Binding ProteinsIon Channel GatingLymphocyte ActivationMembrane PotentialsMiceMice, Inbred C3HMice, Inbred C57BLMutationNFATC Transcription FactorsNuclear ProteinsPatch-Clamp TechniquesPhosphorylationProtein SubunitsReceptors, Antigen, T-CellT-LymphocytesTranscription FactorsConceptsT lymphocytesCalcium channelsVoltage-gated calcium channelsT lymphocyte functionT cell receptor stimulationCell receptor stimulationCytokine productionLymphocyte functionCalcium influxReceptor stimulationCalcium responseCalcium entryTranscription factor NFATCav1 channelsLymphocytesAlpha1 subunitCav channelsNormal functionNonexcitable cellsDisplay impairmentsExcitable cellsChannel openingMolecular identityDiverse physiological processesPhysiological processes
2002
The Spectrin-Ankyrin Skeleton Controls CD45 Surface Display and Interleukin-2 Production
Pradhan D, Morrow J. The Spectrin-Ankyrin Skeleton Controls CD45 Surface Display and Interleukin-2 Production. Immunity 2002, 17: 303-315. PMID: 12354383, DOI: 10.1016/s1074-7613(02)00396-5.Peer-Reviewed Original ResearchMeSH KeywordsAnkyrinsCD3 ComplexCell MembraneHumansInterleukin-2Jurkat CellsLeukocyte Common AntigensLymphocyte ActivationMacromolecular SubstancesMembrane GlycoproteinsNeoplasm ProteinsPeptide FragmentsProtein BindingProtein Interaction MappingProtein IsoformsProtein Structure, TertiaryRecombinant Fusion ProteinsSpectrinStructure-Activity RelationshipT-LymphocytesTransfectionConceptsJurkat T cellsT cell receptor stimulationCell receptor stimulationCytoplasmic domainSurface recruitmentBetaI spectrinSpectrin peptidesT cell activationSurface displayIntracellular poolUnexpected contributionAnkyrinSpectrinCell activationReceptor stimulationCD45T cellsCellsInterleukin-2 productionGlycoproteinRecruitmentT lymphocyte functionActivationLymphocyte functionPool
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