Membrane‐bound Dickkopf‐1 in Foxp3+ regulatory T cells suppresses T‐cell‐mediated autoimmune colitis
Chae W, Park J, Henegariu O, Yilmaz S, Hao L, Bothwell ALM. Membrane‐bound Dickkopf‐1 in Foxp3+ regulatory T cells suppresses T‐cell‐mediated autoimmune colitis. Immunology 2017, 152: 265-275. PMID: 28556921, PMCID: PMC5588763, DOI: 10.1111/imm.12766.Peer-Reviewed Original ResearchMeSH KeywordsAdoptive TransferAnimalsAutoimmune DiseasesAutoimmunityCell MembraneCell ProliferationCHO CellsColitisColonCricetulusDisease Models, AnimalDNA-Binding ProteinsForkhead Transcription FactorsGenetic Predisposition to DiseaseIntercellular Signaling Peptides and ProteinsLymphocyte ActivationMice, Inbred C57BLMice, KnockoutMitogen-Activated Protein KinasesPhenotypeSelf ToleranceSignal TransductionT-Lymphocytes, RegulatoryTime FactorsTransfectionConceptsRegulatory T cellsTreg cellsDKK-1 expressionAutoimmune colitisDickkopf-1T cellsT cell-mediated toleranceEffector CD4 T cellsCD4 T cellsInduction of toleranceT cell proliferationT cell receptor stimulationNovel TregColitis modelImmunological homeostasisImmunological toleranceFoxp3Receptor stimulationCanonical Wnt pathwayColitisFunctional inhibitionMonoclonal antibodiesDe novo protein synthesisProtein kinase pathwaySuppressor functionMembrane-bound Dickkopf-1 in Foxp3+ regulatory T cells suppresses T cell-mediated autoimmune colitis
Chae W, Hao L, Henegariu O, Yilmaz S, Bothwell A. Membrane-bound Dickkopf-1 in Foxp3+ regulatory T cells suppresses T cell-mediated autoimmune colitis. The Journal Of Immunology 2017, 198: 156.8-156.8. DOI: 10.4049/jimmunol.198.supp.156.8.Peer-Reviewed Original ResearchDKK-1 expressionDickkopf-1T cellsImmunological toleranceT cell-mediated toleranceEffector CD4 T cellsT cell-mediated colitisRegulatory T cellsCD4 T cellsT cell receptor stimulationCell receptor stimulationActivated TregsAutoimmune colitisTreg markersColitis modelReceptor stimulationTregsCanonical Wnt pathwayDe novo protein synthesisCell proliferationColitisWnt pathwayNovo protein synthesisMAPK pathwayWnt ligands
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