2025
Scalp rhythmic epileptiform discharges in focal cortical dysplasia: A clinicopathological study
Xu S, Ming W, Hong B, Zhou J, Jin B, Lv J, Zheng Z, Jiang H, Shen C, Wang Z, Wang Y, Ding M, Xu J, Wang S, Zheng Y. Scalp rhythmic epileptiform discharges in focal cortical dysplasia: A clinicopathological study. Clinical Neurophysiology 2025, 174: 10-16. PMID: 40179633, DOI: 10.1016/j.clinph.2025.03.031.Peer-Reviewed Original ResearchConceptsRhythmic epileptiform dischargesFocal cortical dysplasia type 2Focal cortical dysplasiaFavorable surgical outcomeSurgical outcomesCortical dysplasiaEpileptiform dischargesAssociated with favorable surgical outcomesType 2Focal cortical dysplasia patientsChloride transportScalp electroencephalogramResection surgeryInterictal patternsClinical significanceClinical variablesPathologic correlationClinicopathological studyExtratemporal regionsPatientsAbnormal expressionPathological cellsPathological substrateDysplasiaElectroencephalogram
2020
Pathways in the Pathophysiology of Coronavirus 19 Lung Disease Accessible to Prevention and Treatment
Eisenhut M, Shin J. Pathways in the Pathophysiology of Coronavirus 19 Lung Disease Accessible to Prevention and Treatment. Frontiers In Physiology 2020, 11: 872. PMID: 32922301, PMCID: PMC7457053, DOI: 10.3389/fphys.2020.00872.Peer-Reviewed Original ResearchCystic fibrosis transmembrane conductance regulatorAcute respiratory distress syndromeTNF-alpha levelsTNF-alphaLung diseaseRandomized Controlled TrialsEpithelial sodiumReduction of TNF-alpha productionCystic fibrosis transmembrane conductance regulator activityChloride transportAnti-TNF-alpha treatmentAlveolar spaceTumor necrosis factor-alphaHuman beta-defensin-2Associated with improved outcomesVitamin D prophylaxisRespiratory distress syndromeTNF-alpha concentrationsTransmembrane conductance regulatorTNF-alpha releasePhosphodiesterase-5 inhibitorsNecrosis factor-alphaTNF-alpha productionImpairment of sodiumBeta-defensin-2
2010
Evidence for intestinal chloride secretion
Murek M, Kopic S, Geibel J. Evidence for intestinal chloride secretion. Quarterly Journal Of Experimental Physiology And Cognate Medical Sciences 2010, 95: 471-478. PMID: 20233891, DOI: 10.1113/expphysiol.2009.049445.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsChloride ChannelsChloridesCLC-2 Chloride ChannelsCystic Fibrosis Transmembrane Conductance RegulatorDiarrheaEnterocytesHumansIntestinal AbsorptionIntestinal MucosaIntestinal SecretionsPotassium ChannelsSodium-Potassium-Chloride SymportersSodium-Potassium-Exchanging ATPaseTight JunctionsWater-Electrolyte Balance
2006
Pendrin Regulation in Mouse Kidney Primarily Is Chloride-Dependent
Vallet M, Picard N, Loffing-Cueni D, Fysekidis M, Bloch-Faure M, Deschênes G, Breton S, Meneton P, Loffing J, Aronson PS, Chambrey R, Eladari D. Pendrin Regulation in Mouse Kidney Primarily Is Chloride-Dependent. Journal Of The American Society Of Nephrology 2006, 17: 2153-2163. PMID: 16825334, DOI: 10.1681/asn.2005101054.Peer-Reviewed Original ResearchConceptsHydrochlorothiazide administrationAldosterone secretionExtracellular fluid volume regulationElevated plasma aldosterone levelsPlasma aldosterone levelsDifferent mouse modelsFluid volume regulationPendrin protein expressionAldosterone levelsSecondary hyperaldosteronismEpithelial sodium channelChloride transportApical Cl-/HCO3Chloride reabsorptionRat modelPendrin expressionMouse modelKnockout miceSemiquantitative immunoblottingNaCl loadingGamma-ENaC subunitsBiologic effectsExperimental modelSodium channelsProtein expression
2002
Formate-stimulated NaCl absorption in the proximal tubule is independent of the pendrin protein
Karniski LP, Wang T, Everett LA, Green ED, Giebisch G, Aronson PS. Formate-stimulated NaCl absorption in the proximal tubule is independent of the pendrin protein. American Journal Of Physiology. Renal Physiology 2002, 283: f952-f956. PMID: 12372770, DOI: 10.1152/ajprenal.00182.2002.Peer-Reviewed Original ResearchConceptsProximal tubulesChloride/formate exchangeNaCl reabsorptionChloride reabsorptionElectroneutral NaCl reabsorptionNaCl absorptionRole of pendrinFormate exchangePds-knockout mouseRecycling of formatePendrin proteinReabsorptionMicePendrinBrush border membrane vesiclesTubulesPresent studyChloride transportApical membrane
1991
Localization of the cystic fibrosis transmembrane conductance regulator in pancreas.
Marino CR, Matovcik LM, Gorelick FS, Cohn JA. Localization of the cystic fibrosis transmembrane conductance regulator in pancreas. Journal Of Clinical Investigation 1991, 88: 712-716. PMID: 1713921, PMCID: PMC295422, DOI: 10.1172/jci115358.Peer-Reviewed Original ResearchConceptsCF transmembrane conductance regulatorCystic fibrosisTransmembrane conductance regulatorCFTR peptidesPancreatic secretory functionDouble-label immunofluorescence studiesConductance regulatorDuct epithelial cellsCystic fibrosis transmembrane conductance regulatorFibrosis transmembrane conductance regulatorPancreatic insufficiencyIntralobular duct cellsSecretory functionHuman pancreasCFTR moleculesChloride transportMonoclonal antibodiesApical domainDuct cellsAntibodiesEpithelial cellsAcinar cellsCFTR proteinImmunofluorescence studiesProtein products
1987
Mechanism of electroneutral sodium chloride absorption in distal colon of the rat
Binder H, Foster E, Budinger M, Hayslett J. Mechanism of electroneutral sodium chloride absorption in distal colon of the rat. Gastroenterology 1987, 93: 449-455. PMID: 3609655, DOI: 10.1016/0016-5085(87)90905-x.Peer-Reviewed Original ResearchConceptsSodium chloride absorptionElectroneutral sodium chloride absorptionNet sodium absorptionNet chloride absorptionDistal colonChloride absorptionSodium absorptionRat distal colonSodium chloride cotransportVoltage-clamp conditionsMM furosemideMM amilorideMucosal bathing solutionChloride transportClamp conditionsColonBathing solutionRatsElectrogenic sodiumMechanism of sodiumAmilorideSodiumAbsence of potassiumCotransportMucosa
1986
Evidence for electroneutral sodium chloride transport in rat proximal convoluted tubule
Howlin KJ, Alpern RJ, Berry CA, Rector FC. Evidence for electroneutral sodium chloride transport in rat proximal convoluted tubule. American Journal Of Physiology 1986, 250: f644-f648. PMID: 3963204, DOI: 10.1152/ajprenal.1986.250.4.f644.Peer-Reviewed Original ResearchConceptsTransepithelial potential differenceLate proximal tubular fluidProximal tubular fluidNaCl transportEffect of cyanideLumen-negative potential differenceSodium chloride transportLuminal perfusateTubular fluidNaCl absorptionTwo-thirdsTubulesPotential differenceChloride transportActive transportPerfusateChloride transport in the mammalian proximal tubule
Schild L, Giebisch G, Karniski L, Aronson PS. Chloride transport in the mammalian proximal tubule. Pflügers Archiv - European Journal Of Physiology 1986, 407: s156-s159. PMID: 3822761, DOI: 10.1007/bf00584945.Commentaries, Editorials and LettersConceptsMammalian proximal tubuleElectroneutral anion exchangeApical cell membraneElectroneutral transportTransport stimulationCell membraneHydrogen exchangeBrushborder membraneProximal tubule cellsChloride transportMembraneProximal tubulesTransport routesTubule cellsPossible transport mechanismsChloride/formate exchangeChloride exchangeRabbit renal cortexChloride movementSubmillimolar concentrationsTubulesVesicles
1985
Sodium and chloride transport across rabbit ileal brush border. II. Evidence for Cl-HCO3 exchange and mechanism of coupling
Knickelbein R, Aronson PS, Schron CM, Seifter J, Dobbins JW. Sodium and chloride transport across rabbit ileal brush border. II. Evidence for Cl-HCO3 exchange and mechanism of coupling. American Journal Of Physiology 1985, 249: g236-g245. PMID: 3927745, DOI: 10.1152/ajpgi.1985.249.2.g236.Peer-Reviewed Original ResearchMeSH Keywords4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic AcidAmilorideAnimalsAnionsBicarbonatesCarbonic AnhydrasesChloridesHydrogen-Ion ConcentrationHydroxidesIleumIn Vitro TechniquesIntestinal AbsorptionIntestinal MucosaMembrane PotentialsMicrovilliModels, BiologicalPotassiumRabbitsSodiumConceptsStimulation of ClBrush border membraneCl- uptakeInside-alkaline pH gradientCl transportCl-HCO3 exchangeRabbit ileumCoupling of NaX minMM ClBrush border vesiclesBrush borderN2-5Saturable functionMM KClNa uptakeLevel fourfoldAddition of HCO3K diffusion potentialsCarbonic anhydrase activityChloride transportUptake
1983
Chloride transport across the basolateral cell membrane of theNecturus proximal tubule: Dependence on bicarbonate and sodium
Guggino W, London R, Boulpaep E, Giebisch G. Chloride transport across the basolateral cell membrane of theNecturus proximal tubule: Dependence on bicarbonate and sodium. The Journal Of Membrane Biology 1983, 71: 227-240. PMID: 6302263, DOI: 10.1007/bf01875464.Peer-Reviewed Original ResearchConceptsBasolateral cell membraneProximal tubule cellsBasolateral solutionNH4Cl exposurePH-sensitive microelectrodesProximal tubulesTubule cellsPerfusion solutionCell membraneIntracellular chlorideTheNecturus proximal tubuleIntracellular pHApical cell membraneNH4Cl treatmentChloride transportChloride activityKidney
1965
Micropuncture study of proximal renal tubular chloride transport during hypercapnea in the rat
Kashgarian M, Warren Y, Levitin H. Micropuncture study of proximal renal tubular chloride transport during hypercapnea in the rat. American Journal Of Physiology 1965, 209: 655-658. PMID: 5837751, DOI: 10.1152/ajplegacy.1965.209.3.655.Peer-Reviewed Original Research
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