2010
In vivo nuclear translocation of mineralocorticoid and glucocorticoid receptors in rat kidney: differential effect of corticosteroids along the distal tubule
Ackermann D, Gresko N, Carrel M, Loffing-Cueni D, Habermehl D, Gomez-Sanchez C, Rossier B, Loffing J. In vivo nuclear translocation of mineralocorticoid and glucocorticoid receptors in rat kidney: differential effect of corticosteroids along the distal tubule. American Journal Of Physiology. Renal Physiology 2010, 299: f1473-f1485. PMID: 20861076, DOI: 10.1152/ajprenal.00437.2010.Peer-Reviewed Original ResearchConceptsAldosterone-sensitive distal nephronThick ascending limbGlucocorticoid receptorLate distal convoluted tubuleLow-dose corticosterone replacementSegment-specific cellsNuclear translocationDietary NaCl loadingDistal convoluted tubuleKidneys of ratsDehydrogenase type 2Proximal tubule cellsAldosterone replacementMineralocorticoid selectivityPlasma aldosteroneCorticosteroid effectsCorticosterone replacementControl ratsDistal tubulesDistal nephronConvoluted tubulesNaCl loadingCorticosterone levelsAscending limbHigh doses
2006
Pendrin Regulation in Mouse Kidney Primarily Is Chloride-Dependent
Vallet M, Picard N, Loffing-Cueni D, Fysekidis M, Bloch-Faure M, Deschênes G, Breton S, Meneton P, Loffing J, Aronson PS, Chambrey R, Eladari D. Pendrin Regulation in Mouse Kidney Primarily Is Chloride-Dependent. Journal Of The American Society Of Nephrology 2006, 17: 2153-2163. PMID: 16825334, DOI: 10.1681/asn.2005101054.Peer-Reviewed Original ResearchConceptsHydrochlorothiazide administrationAldosterone secretionExtracellular fluid volume regulationElevated plasma aldosterone levelsPlasma aldosterone levelsDifferent mouse modelsFluid volume regulationPendrin protein expressionAldosterone levelsSecondary hyperaldosteronismEpithelial sodium channelChloride transportApical Cl-/HCO3Chloride reabsorptionRat modelPendrin expressionMouse modelKnockout miceSemiquantitative immunoblottingNaCl loadingGamma-ENaC subunitsBiologic effectsExperimental modelSodium channelsProtein expression
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