2019
The Role of Bowel Preparation in Open, Minimally Invasive, and Converted-to-Open Colectomy
Luo J, Liu Z, Pei KY, Khan SA, Wang X, Yang M, Wang X, Zhang Y. The Role of Bowel Preparation in Open, Minimally Invasive, and Converted-to-Open Colectomy. Journal Of Surgical Research 2019, 242: 183-192. PMID: 31085366, DOI: 10.1016/j.jss.2019.02.039.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, OralAgedAged, 80 and overAnti-Bacterial AgentsAntibiotic ProphylaxisCatharticsColectomyColonic DiseasesConversion to Open SurgeryElective Surgical ProceduresFemaleHospital MortalityHumansLaparoscopyLength of StayMaleMiddle AgedPostoperative ComplicationsPreoperative CareRetrospective StudiesRobotic Surgical ProceduresConceptsAntibiotic bowel preparationMechanical bowel preparationBowel preparationProtective effectElective colectomyPostoperative complicationsMajor complicationsReduced riskMultivariate logistic regression modelLength of stayStrong protective effectLogistic regression modelsStudy time periodInfectious complicationsAnastomotic leakOpen colectomyPreoperative strategyInvasive colectomyOpen groupColectomyAmerican CollegeComplicationsPatientsOverall populationRobotic surgery
2011
Strong protective effect of the aldehyde dehydrogenase gene (ALDH2) 504lys (*2) allele against alcoholism and alcohol-induced medical diseases in Asians
Li D, Zhao H, Gelernter J. Strong protective effect of the aldehyde dehydrogenase gene (ALDH2) 504lys (*2) allele against alcoholism and alcohol-induced medical diseases in Asians. Human Genetics 2011, 131: 725-737. PMID: 22102315, PMCID: PMC3548401, DOI: 10.1007/s00439-011-1116-4.Peer-Reviewed Original ResearchConceptsAlcohol dependenceAlcohol-induced liver diseaseStrong associationCase-control studyPathogenesis of ADSub-group analysisStrong protective effectRandom-effects modelP-valueAldehyde dehydrogenase 2 geneLiver diseaseMedical illnessMedical diseasesProtective effectAlcohol abuseLys alleleAcetaldehyde metabolismAsian populationsStatistical significanceStrict criteriaALDH2 geneEffects modelAssociationDiseaseDominant model
2008
The Tick Salivary Protein Salp15 Inhibits the Killing of Serum-Sensitive Borrelia burgdorferi Sensu Lato Isolates
Schuijt TJ, Hovius JW, van Burgel ND, Ramamoorthi N, Fikrig E, van Dam AP. The Tick Salivary Protein Salp15 Inhibits the Killing of Serum-Sensitive Borrelia burgdorferi Sensu Lato Isolates. Infection And Immunity 2008, 76: 2888-2894. PMID: 18426890, PMCID: PMC2446733, DOI: 10.1128/iai.00232-08.Peer-Reviewed Original ResearchConceptsComplement-mediated killingBurgdorferi-specific antibodiesBorrelia burgdorferiStrong protective effectSerum-sensitive isolatesNormal human serumBorrelia burgdorferi sensu latoBurgdorferi sensu latoProtective effectMembrane attack complexTick salivaLyme diseaseBorrelia burgdorferi sensu lato isolatesComplement complexI. scapularis Salp15B. burgdorferiSalp15Attack complexBurgdorferiHuman serumKillingSpirochetesIxodes scapularisIsolatesTicks
2001
Effects of CCR5-Delta32, CCR2-64I, and SDF-1 3'A alleles on HIV-1 disease progression: An international meta-analysis of individual-patient data.
Ioannidis J, Rosenberg P, Goedert J, Ashton L, Benfield T, Buchbinder S, Coutinho R, Eugen-Olsen J, Gallart T, Katzenstein T, Kostrikis L, Kuipers H, Louie L, Mallal S, Margolick J, Martinez O, Meyer L, Michael N, Operskalski E, Pantaleo G, Rizzardi G, Schuitemaker H, Sheppard H, Stewart G, Theodorou I, Ullum H, Vicenzi E, Vlahov D, Wilkinson D, Workman C, Zagury J, O'Brien T. Effects of CCR5-Delta32, CCR2-64I, and SDF-1 3'A alleles on HIV-1 disease progression: An international meta-analysis of individual-patient data. Annals Of Internal Medicine 2001, 135: 782-95. PMID: 11694103, DOI: 10.7326/0003-4819-135-9-200111060-00008.Peer-Reviewed Original ResearchConceptsHIV-1 infectionCCR2-64I alleleHIV-1 RNA levelsHIV-1 disease progressionDevelopment of AIDSIndividual patient dataCCR5-Delta32Decreased riskDisease progressionProtective effectLower HIV-1 RNA levelsRNA levelsProspective cohort studyCase-control studyClear protective effectStrong protective effectChemokine receptor genesRandom-effects modelCCR2-64ICohort studyStudy entryCertain chemokinesAIDSInfectionProgression
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