2024
Biodistribution of Polymeric Nanoparticles following in utero Delivery to a Nonhuman Primate
Eaton D, Lynn A, Surprenant J, Deschenes E, Guerra M, Rivero R, Yung N, O'Connor M, Glazer P, Bahtiyar M, Saltzman W, Stitelman D. Biodistribution of Polymeric Nanoparticles following in utero Delivery to a Nonhuman Primate. Biomedicine Hub 2024, 10: 543138. PMID: 39845408, PMCID: PMC11753793, DOI: 10.1159/000543138.Peer-Reviewed Original ResearchMonogenic diseasesNon-human primatesBiodistribution of polymeric nanoparticlesPreclinical mouse modelsStem cell populationFetal liverFetal malesSystemic deliveryFetal bonesAccumulation of NPIn-uteroMid-gestationNP accumulationBiodistribution studiesPolymeric NPsTherapeutic accessCell populationsMaternal tissuesZone of proliferationPolymeric nanoparticlesDiseaseBirthMiceDeliveryBiodistributionDisordered but effective: short linear motifs as gene therapy targets for hyperexcitability disorders
Dib-Hajj S, Waxman S. Disordered but effective: short linear motifs as gene therapy targets for hyperexcitability disorders. Journal Of Clinical Investigation 2024, 134: e182198. PMID: 38949022, PMCID: PMC11213459, DOI: 10.1172/jci182198.Peer-Reviewed Original ResearchConceptsTetrodotoxin-sensitiveHyperexcitability disordersSensory neuronsExcitability of sensory neuronsGene therapy modalitiesPeripheral sensory neuronsVoltage-gated sodiumMinimal side effectsGene therapyInduce analgesiaTherapy modalitiesSide effectsTherapeutic strategiesNav channelsAttenuating excitationIn vivoHyperexcitabilityAnalgesiaNeuronsDisordersPainTherapyGenesBiodistributionRatsPilot PET study of vaginally administered bioadhesive nanoparticles in cynomolgus monkeys: Kinetics and safety evaluation
Grun M, Honhar P, Wang Y, Rossano S, Khang M, Suh H, Fowles K, Kliman H, Cavaliere A, Carson R, Marquez‐Nostra B, Saltzman W. Pilot PET study of vaginally administered bioadhesive nanoparticles in cynomolgus monkeys: Kinetics and safety evaluation. Bioengineering & Translational Medicine 2024, 9: e10661. PMID: 39553429, PMCID: PMC11561825, DOI: 10.1002/btm2.10661.Peer-Reviewed Original ResearchVaginal dosage formsBioadhesive nanoparticlesCynomolgus monkeysAnalysis of inflammatory biomarkersVaginal microbicidesVaginal canalMultiple dosesInflammatory biomarkersTherapeutic efficacyVaginal fluidSystemic circulationLong-term deliveryNoninvasive imagingClinical translationDosage formsNon-human primatesDelivery vehiclesMonkeysDeliveryVaginitisUterusMicrobicidesSafety evaluationBiodistributionDose
2023
Head-to-head comparison of in vitro and in vivo efficacy of pHLIP-conjugated anti-seed gamma peptide nucleic acids
Dhuri K, Duran T, Chaudhuri B, Slack F, Vikram A, Glazer P, Bahal R. Head-to-head comparison of in vitro and in vivo efficacy of pHLIP-conjugated anti-seed gamma peptide nucleic acids. Cell Reports Physical Science 2023, 4: 101584. PMID: 38144419, PMCID: PMC10745205, DOI: 10.1016/j.xcrp.2023.101584.Peer-Reviewed Original Research
2021
Evolution of Toll-like receptor 7/8 agonist therapeutics and their delivery approaches: From antiviral formulations to vaccine adjuvants
Bhagchandani S, Johnson J, Irvine D. Evolution of Toll-like receptor 7/8 agonist therapeutics and their delivery approaches: From antiviral formulations to vaccine adjuvants. Advanced Drug Delivery Reviews 2021, 175: 113803. PMID: 34058283, PMCID: PMC9003539, DOI: 10.1016/j.addr.2021.05.013.Peer-Reviewed Original ResearchConceptsVaccine adjuvantsImidazoquinoline derivativesToll-like receptor 7Candidate vaccine adjuvantsSkin cancer treatmentBroad therapeutic utilityTLR7 toleranceTopical antiviralsImmunomodulatory agentsReceptor 7Systemic administrationPoor pharmacokinetic propertiesTherapeutic utilitySuccessful clinical translationSynthetic agonistsAntiviral formulationsInfectious diseasesPharmacokinetic propertiesCancer treatmentBroad expression profileAdjuvantClinical translationBiodistributionExpression profilesTherapeutics
2020
Altered FDG Biodistribution in Subcutaneous White Fat on PET/CT Following l-Asparaginase Chemotherapy.
Young CR, Kulon ME, Boustani AM, Pucar D. Altered FDG Biodistribution in Subcutaneous White Fat on PET/CT Following l-Asparaginase Chemotherapy. Clinical Nuclear Medicine 2020, 46: e179-e180. PMID: 33086270, DOI: 10.1097/rlu.0000000000003340.Peer-Reviewed Original ResearchConceptsPET/CTAltered biodistributionMediastinal T-cell lymphoblastic lymphomaPosttreatment FDG PET/CTFDG PET/CTT-cell lymphoblastic lymphomaSubcutaneous white adipose tissueWhite adipose tissueTreatment response assessmentSubcutaneous white fatAsparaginase chemotherapyLymphoblastic lymphomaAsparaginase resistanceFDG biodistributionResponse assessmentWhite fatGlucose metabolismAdipose tissueTreatment cyclesLeukemic cellsVisceral activityCTBiodistributionChemotherapyDiffuse activity
2015
Nanoparticles for Cardiovascular Imaging and Therapeutic Delivery, Part 1: Compositions and Features
Stendahl JC, Sinusas AJ. Nanoparticles for Cardiovascular Imaging and Therapeutic Delivery, Part 1: Compositions and Features. Journal Of Nuclear Medicine 2015, 56: 1469-1475. PMID: 26272808, PMCID: PMC4934895, DOI: 10.2967/jnumed.115.160994.BooksConceptsTherapeutic deliveryMultifunctional imaging agentsTargeted molecular imagingTunable propertiesSmall moleculesVersatile platformNanoparticlesUnique propertiesSmall molecule agentsImaging agentIntriguing attributesClinical translationMolecular imagingPharmacokinetic limitationsPropertiesElimination propertiesDiscusses challengesScope of applicationMoleculesHigh-resolution imaging modalityDeliveryMicroparticlesAgentsBiodistributionPlatformPET imaging of a collagen matrix reveals its effective injection and targeted retention in a mouse model of myocardial infarction
Ahmadi A, Thorn SL, Alarcon EI, Kordos M, Padavan DT, Hadizad T, Cron GO, Beanlands RS, DaSilva JN, Ruel M, deKemp RA, Suuronen EJ. PET imaging of a collagen matrix reveals its effective injection and targeted retention in a mouse model of myocardial infarction. Biomaterials 2015, 49: 18-26. PMID: 25725551, DOI: 10.1016/j.biomaterials.2015.01.016.Peer-Reviewed Original ResearchConceptsMyocardial infarctionPositron emission tomographyPET imagingMouse modelNon-invasive PET imagingCardiac regeneration therapyIschemic territoryPET resultsInfarcted myocardiumEmission tomographyCollagen matrixMyocardial injectionEarly retentionPromising modalityRegeneration therapyInfarctionLabeling efficiencyMyocardiumFluorescence imagingImagingBiodistributionInjectionQdot labelingEx
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