2024
Long-term natural history of ellipsoid zone width in USH2A-retinopathy
Heyang M, Warren J, Ocieczek P, Duncan J, Moosajee M, Del Priore L, Shen L. Long-term natural history of ellipsoid zone width in USH2A-retinopathy. British Journal Of Ophthalmology 2024, 109: 383-390. PMID: 39103200, PMCID: PMC11866300, DOI: 10.1136/bjo-2024-325323.Peer-Reviewed Original ResearchAvocational exposure associations with ALS risk, survival, and phenotype: A Michigan-based case-control study
Goutman S, Boss J, Jang D, Piecuch C, Farid H, Batra M, Mukherjee B, Feldman E, Batterman S. Avocational exposure associations with ALS risk, survival, and phenotype: A Michigan-based case-control study. Journal Of The Neurological Sciences 2024, 457: 122899. PMID: 38278093, PMCID: PMC11060628, DOI: 10.1016/j.jns.2024.122899.Peer-Reviewed Original ResearchConceptsALS riskLower educational attainmentAssociated with ALS riskCase-control studyExercise 5Onset ageSelf-completionExposure variablesYard workExposure associationsRecreational danceIdentified exposureExerciseEducational attainmentAL burdenEnvironmental exposuresParticipantsAL factorPersonal participationAvocational exposureRiskExposomeHobbiesALS onsetComparison correction
2022
Use and Product Characteristics of “Tobacco Free Nicotine” E-Cigarettes Among Young Adults
Davis DR, Bold KW, Camenga D, Kong G, Jackson A, Lee J, Rajesh-Kumar L, Krishnan-Sarin S, Morean ME. Use and Product Characteristics of “Tobacco Free Nicotine” E-Cigarettes Among Young Adults. Nicotine & Tobacco Research 2022, 25: 379-385. PMID: 35913677, PMCID: PMC9910142, DOI: 10.1093/ntr/ntac188.Peer-Reviewed Original ResearchConceptsE-cigarette useFrequent e-cigarette useE-cigarettesYoung adultsAdjusted modelMore frequent e-cigarette useNicotine pouchesMultivariable adjusted modelsE-cigarette use statusNicotine e-cigarettesLogistic regression modelsBinary logistic regression modelRace/ethnicityU.S. young adultsOnset ageYounger ageBivariate comparisonsNicotine concentrationsTobacco productsAlcohol useAdultsFree nicotineUse statusLifetime frequencyLifetime e-cigarette use
2019
Earlier Onset in Autosomal Dominant Hypophosphatemic Rickets of R179 than R176 Mutations in Fibroblast Growth Factor 23: Report of 20 Chinese Cases and Review of the Literature
Liu C, Zhao Z, Wang O, Li M, Xing X, Hsieh E, Fukumoto S, Jiang Y, Xia W. Earlier Onset in Autosomal Dominant Hypophosphatemic Rickets of R179 than R176 Mutations in Fibroblast Growth Factor 23: Report of 20 Chinese Cases and Review of the Literature. Calcified Tissue International 2019, 105: 476-486. PMID: 31486862, DOI: 10.1007/s00223-019-00597-y.Peer-Reviewed Original ResearchConceptsAutosomal dominant hypophosphatemic ricketsLower extremity deformitiesDominant hypophosphatemic ricketsExtremity deformitiesOnset ageHypophosphatemic ricketsFibroblast growth factor 23Growth factor 23Onset of diseaseRU/mLHistory of ricketsEarlier onset ageAge of onsetRare hereditary disorderPg/mLGenotype-phenotype correlationI-FGF23Symptomatic patientsFactor 23More patientsSerum phosphateClinical manifestationsLaboratory examinationsOvert symptomsMutation carriers
2018
Identification of genetic risk factors in the Chinese population implicates a role of immune system in Alzheimer’s disease pathogenesis
Zhou X, Chen Y, Mok K, Zhao Q, Chen K, Chen Y, Hardy J, Li Y, Fu A, Guo Q, Ip N, Saykin A, Toga A, Borowski B, Ward C, DeCarli C, Mathis C, Jack C, Harvey D, Holtzman D, Jones D, Gessert D, Lilly E, Reiman E, Franklin E, Hefti F, Sorensen G, Jimenez G, Fillit H, Gunter J, Salazar J, Hsiao J, Morris J, Trojanowki J, Neu K, Kantarci K, Faber K, Harless K, Chen K, Nho K, Beckett L, Thal L, Thal L, Shaw L, Kuller L, Shen L, Hergesheimer L, Taylor-Reinwald L, Mesulam M, Korecka M, Raichle M, Carrillo M, Albert M, Senjem M, Bernstein M, Donohue M, Weiner M, Figurski M, Buckholtz N, Fox N, Cairns N, Schuff N, Foster N, Aisen P, Thompson P, Davies P, Snyder P, Snyder P, Vemuri P, Frank R, Koeppe R, Green R, Petersen R, Walter S, Paul S, Potkin S, Kim S, Foroud T, Montine T, Lee V, Jagust W, Potter W, Cabrera Y, Khachaturian Z, Fleisher A, Pierce A, Mintz A, Lerner A, Norbash A, Levey A, Rosen A, Smith A, Ulysse A, Budson A, Kertesz A, Oliver A, Hake A, Burke A, Sarrael A, Porsteinsson A, Lamb A, Lee A, Raj B, Lane B, Yanez B, Ances B, Mudge B, Lind B, Stefanovic B, Goldstein B, Bonakdarpour B, Matthews B, Ott B, Reynolds B, Miller B, Spann B, Sadowsky C, Bernick C, Smith C, Onyike C, Heyn C, Hosein C, Leach C, Belden C, van Dyck C, Clark C, Wu C, Albers C, Brand C, Bodge C, Tatsuoka C, Carlsson C, Mathews D, D’Agostino D, Silverman D, Marson D, Wolk D, Bachman D, Clark D, Geldmacher D, Hart D, Knopman D, Perry D, Winkfield D, Miller D, Kerwin D, Drost D, Simpson D, Munic D, Scharre D, Bartha R, Celmins D, Zimmerman E, Teng E, Coleman E, Zamrini E, Mitsis E, Finger E, Oates E, Sosa E, Woo E, Rogalski E, Fletcher E, Parfitt F, Thai G, Marshall G, Conrad G, Tremont G, Bartzokis G, Hsiung G, Chiang G, Pearlson G, Jicha G, Vanderswag H, Grossman H, Capote H, Bergman H, Chertkow H, Feldman H, Rosen H, Koleva H, Shim H, Rachinsky I, Mintzer J, Ziolkowski J, Brewer J, Lah J, Singleton-Garvin J, Cellar J, Brosch J, Tinklenberg J, Karlawish J, Villanueva-Meyer J, Kaye J, Burns J, Petrella J, Yesavage J, Allard J, Lord J, Hetelle J, Brockington J, Morris J, Olichney J, Rogers J, Quinn J, Kass J, Taylor J, Heidebrink J, Anderson K, Blank K, Smith K, Bell K, Johnson K, Tingus K, DeMarco K, Sink K, Johnson K, Makino K, Spicer K, Nam K, Martin K, Poki-Walker K, Johnson K, Fargher K, Lipowski K, Womack K, Flashman L, Honig L, Apostolova L, Teodoro L, Silbert L, Ravdin L, Schneider L, Daiello L, Ismail M, Seltzer M, Mesulam M, Carroll M, Kataki M, Greig-Custo M, Love M, Mintun M, Farlow M, Sadowski M, Creech M, Hynes M, Quiceno M, Oakley M, Becerra M, Witbracht M, Keltz M, Lamar M, Yang M, Borrie M, Lin M, Assaly M, Rainka M, Dang M, Sheikh M, Gaikwad M, Chowdhury M, Trncic N, Johnson N, Kowalksi N, Pacini N, Kowall N, Graff-Radford N, Relkin N, Oyonumo N, Pomara N, James O, Ogunlana O, Lopez O, Carmichael O, Doraiswamy P, Fatica P, Johnson P, Samuels P, Malloy P, Ogrocki P, Maillard P, Hardy P, Tariot P, Lu P, Varma P, Doody R, Carter R, Shah R, Griffith R, Yeh R, Duara R, Tarawneh R, Turner R, Hernando R, Sperling R, Carson R, El Khouli R, Santulli R, Killiany R, Rodriguez R, Swerdlow R, Borges-Neto S, Black S, Weintraub S, Asthana S, Vaishnavi S, Dolen S, Mason S, Kremen S, Herring S, Sirrel S, Kittur S, Pawluczyk S, Schneider S, Kielb S, Reeder S, Correia S, Pasternack S, Pasternak S, Salloway S, Johnson S, Chao S, Arnold S, Schultz S, Rountree S, Lee T, Wong T, Villena T, Obisesan T, Pavlik V, Bates V, Sossi V, Shibley V, Brooks W, Pavlosky W, Stern Y, Simon A, Dongre A, Dean B, Navia B, Spellman D, Lee D, Shera D, Siemers E, Pickering E, Swenson F, Immerman F, Nomikos G, Soares H, Wan H, Seeburger J, Waring J, Trojanowski J, Siuciak J, Duffin K, Shaw L, Wang L, Thambisetty M, Walton M, Savage M, Ferm M, Kuhn M, Buckholtz N, Zagouras P, Cole P, Hendrickson R, Xie S, Allauzen S, Koroshetz W, Potter W. Identification of genetic risk factors in the Chinese population implicates a role of immune system in Alzheimer’s disease pathogenesis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2018, 115: 1697-1706. PMID: 29432188, PMCID: PMC5828602, DOI: 10.1073/pnas.1715554115.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseChinese populationAD subjectsDisease pathogenesisImmune systemPlasma biomarker levelsEarly disease onsetMinor allele carriersAlzheimer's disease (AD) pathogenesisGenetic risk factorsImmune-related pathwaysCommon variantsGenotype-phenotype analysisDisease onsetRisk factorsBiomarker levelsLeading causeOnset ageAllele carriersAD riskAD cohortPossible risk effectsFunctional effectsExpression levelsRegulatory effects
2016
Do Familial Aortic Dissections Tend to Occur at the Same Age?
Chou AS, Ma WG, Mok SC, Ziganshin BA, Peterss S, Rizzo JA, Tranquilli M, Elefteriades JA. Do Familial Aortic Dissections Tend to Occur at the Same Age? The Annals Of Thoracic Surgery 2016, 103: 546-550. PMID: 27570161, DOI: 10.1016/j.athoracsur.2016.06.007.Peer-Reviewed Original Research
2006
Age-dependent loss of tolerance to an immunodominant epitope of glutamic acid decarboxylase in diabetic-prone RIP-B7/DR4 mice
Gebe J, Unrath K, Falk B, Ito K, Wen L, Daniels T, Lernmark Å, Nepom G. Age-dependent loss of tolerance to an immunodominant epitope of glutamic acid decarboxylase in diabetic-prone RIP-B7/DR4 mice. Clinical Immunology 2006, 121: 294-304. PMID: 16979383, PMCID: PMC1850983, DOI: 10.1016/j.clim.2006.08.002.Peer-Reviewed Original ResearchConceptsGlial fibrillary acidic proteinNon-diabetic miceGlutamic acid decarboxylaseImmunodominant epitopesAcid decarboxylaseIslet-specific glucose-6-phosphatase catalytic subunit-related proteinHLA transgenic miceMean onset ageFibrillary acidic proteinAge-dependent lossIslet infiltratesOvert diabetesDiabetic miceFemale miceHistological evidenceMale miceDR4 miceYoung miceOnset ageProliferative responseDiabetic diseaseTransgenic miceImmunogenic epitopesAcidic proteinMice
1997
Sex Differences in Schizophrenia
Pearlson G, Schlaepfer T. Sex Differences in Schizophrenia. JAMA Psychiatry 1997, 54: 189-189. PMID: 9040289, DOI: 10.1001/archpsyc.1997.01830140101019.Peer-Reviewed Original ResearchConceptsClinical symptomsSex differencesPathogenesis of schizophreniaBiological risk markersEpidemiological characteristicsRisk markersEpidemiological featuresRisk factorsPathogenetic mechanismsBrain changesOnset ageSuch sex differencesReceptor hypothesisSchizophreniaSymptomsLateralization modelCortex modelDifferencesPathogenesis
1985
Pupillary measures of binocular luminance summation in infants and stereoblind adults.
Shea S, Doussard-Roosevelt J, Aslin R. Pupillary measures of binocular luminance summation in infants and stereoblind adults. Investigative Ophthalmology & Visual Science 1985, 26: 1064-70. PMID: 4019097.Peer-Reviewed Original ResearchConceptsBinocular luminance summationPupillary measuresPupillary systemPreverbal infantsFourth postnatal monthStandard clinical measuresStrabismic infantsBinocular functionStereoscopic performanceDevelopmental changesLuminance summationStereopsisBest predictorClinical measuresAdultsMeasuresOnset agePostnatal month
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