2017
Deep‐targeted sequencing of endothelial nitric oxide synthase gene exons uncovers exercise intensity and ethnicity‐dependent associations with post‐exercise hypotension
Pescatello LS, Schifano ED, Ash GI, Panza GA, Corso LML, Chen M, Deshpande V, Zaleski A, Cilhoroz B, Farinatti P, Taylor BA, O'Neill RJ, Thompson PD. Deep‐targeted sequencing of endothelial nitric oxide synthase gene exons uncovers exercise intensity and ethnicity‐dependent associations with post‐exercise hypotension. Physiological Reports 2017, 5: e13510. PMID: 29180482, PMCID: PMC5704084, DOI: 10.14814/phy2.13510.Peer-Reviewed Original ResearchConceptsPost-exercise hypotensionAmbulatory blood pressure responsesBlood pressure responseAmbulatory BP monitorObese African AmericansModerate-intensity exerciseModerate-intensity cyclingMultiple testing thresholdDiastolic BPAcute exerciseValidation cohortBP measurementsBP monitorIntensity exerciseVigorous intensityVariant genotypesIntensity cyclingMmHgTesting thresholdMinor alleleModerate intensityPressure responseHypotensionHypertensionAfrican Americans
2016
Deep‐targeted exon sequencing reveals renal polymorphisms associate with postexercise hypotension among African Americans
Pescatello LS, Schifano ED, Ash GI, Panza GA, Lamberti L, Chen M, Deshpande V, Zaleski A, Farinatti P, Taylor BA, Thompson PD. Deep‐targeted exon sequencing reveals renal polymorphisms associate with postexercise hypotension among African Americans. Physiological Reports 2016, 4: e12992. PMID: 27940662, PMCID: PMC5064144, DOI: 10.14814/phy2.12992.Peer-Reviewed Original ResearchConceptsMultiple testing thresholdADD1 variantsAngiotensin type 1 receptorAmbulatory blood pressure responsesTesting thresholdBlood pressure responseExon sequencingAmbulatory BP monitorModerate-intensity exerciseType 1 receptorModerate-intensity cyclingPostexercise hypotensionRenal variantDiastolic BPAcute exerciseValidation cohortBP measurementsBP monitorIntensity exerciseVigorous intensityAdducin geneVariant genotypesAldosterone synthaseIntensity cyclingCYP11B2 variantsDetermination of a Testing Threshold for Lumbar Puncture in the Diagnosis of Subarachnoid Hemorrhage after a Negative Head Computed Tomography: A Decision Analysis
Taylor RA, Gill H, Marcolini EG, Meyers HP, Faust JS, Newman DH. Determination of a Testing Threshold for Lumbar Puncture in the Diagnosis of Subarachnoid Hemorrhage after a Negative Head Computed Tomography: A Decision Analysis. Academic Emergency Medicine 2016, 23: 1119-1127. PMID: 27378053, DOI: 10.1111/acem.13042.Peer-Reviewed Original ResearchConceptsProbabilistic sensitivity analysesNegative head CTAneurysmal subarachnoid hemorrhageSubarachnoid hemorrhageLumbar punctureNegative CTTesting thresholdHead CTNormal neurologic findingsContrast-induced nephropathyNonaneurysmal subarachnoid hemorrhageLong-term morbidityHead Computed TomographyTwo-way sensitivity analysesDecision analytic modelProbability of deathNeurologic findingsRenal failureClinical variablesCurrent guidelinesPretest probabilityComputed tomographySecondary aimCTHemorrhage
2013
A decision analysis to determine a testing threshold for computed tomographic angiography and d-dimer in the evaluation of aortic dissection
Taylor RA, Iyer NS. A decision analysis to determine a testing threshold for computed tomographic angiography and d-dimer in the evaluation of aortic dissection. The American Journal Of Emergency Medicine 2013, 31: 1047-1055. PMID: 23702073, DOI: 10.1016/j.ajem.2013.03.039.Peer-Reviewed Original ResearchConceptsThoracic aortic dissectionD-dimerTesting thresholdAortic dissectionTomographic angiographyAcute renal failureHigh-risk featuresRenal replacement therapyClinical decision ruleD-dimer testingD-dimer sensitivityD-dimer testLarge mortality benefitMortality benefitPatient ageRenal failureReplacement therapyPretest probabilityLow prevalenceCTA testSmall riskDecision analysis softwareDisease probabilityCTAAngiography
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