2008
Deciphering the assembly pathway of Sm‐class U snRNPs
Neuenkirchen N, Chari A, Fischer U. Deciphering the assembly pathway of Sm‐class U snRNPs. FEBS Letters 2008, 582: 1997-2003. PMID: 18348870, DOI: 10.1016/j.febslet.2008.03.009.Peer-Reviewed Original ResearchConceptsU snRNPsAssembly pathwayUridine-rich small nuclear ribonucleoproteinsProtein arginine methyltransferase 5SMN complex functionTrans-acting factorsSmall nuclear ribonucleoproteinNuclear ribonucleoproteinCommon proteinsSurvival motor neuronSm classSnRNPsProteinPathwayMotor neuronsRibonucleoproteinRecent progressRNASMNAssemblyLarge numberVitroVivoComplexes
2006
A Comprehensive Interaction Map of the Human Survival of Motor Neuron (SMN) Complex*
Otter S, Grimmler M, Neuenkirchen N, Chari A, Sickmann A, Fischer U. A Comprehensive Interaction Map of the Human Survival of Motor Neuron (SMN) Complex*. Journal Of Biological Chemistry 2006, 282: 5825-5833. PMID: 17178713, DOI: 10.1074/jbc.m608528200.Peer-Reviewed Original ResearchConceptsMotor neurons (SMN) complexSMN complexComprehensive interaction mapInteraction mapSm proteinsSMN proteinSpinal muscular atrophy (SMA) disease geneRich small nuclear ribonucleoproteinSmall nuclear ribonucleoproteinAssembly machineryU snRNPsProtein SMNU snRNAsNuclear ribonucleoproteinDisease genesSm classGemins 2ProteinSnRNANovel assayModular compositionMultiple interactionsComplexesGemin5Major component
2005
Small Nuclear RNAs Encoded by Herpesvirus saimiri Upregulate the Expression of Genes Linked to T Cell Activation in Virally Transformed T Cells
Cook HL, Lytle JR, Mischo HE, Li MJ, Rossi JJ, Silva DP, Desrosiers RC, Steitz JA. Small Nuclear RNAs Encoded by Herpesvirus saimiri Upregulate the Expression of Genes Linked to T Cell Activation in Virally Transformed T Cells. Current Biology 2005, 15: 974-979. PMID: 15916956, DOI: 10.1016/j.cub.2005.04.034.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, CDAntigens, Differentiation, T-LymphocyteAntigens, NeoplasmBase PairingBlotting, NorthernBlotting, WesternCallithrixCD52 AntigenCell Line, TumorFlow CytometryGenetic VectorsGenome, ViralGlycoproteinsHerpesvirus 2, SaimiriineLentivirusLymphocyte ActivationMembrane ProteinsMicroarray AnalysisOncogene Proteins, ViralReceptors, Antigen, T-CellReceptors, ImmunologicRNA, Small NuclearT-LymphocytesTransduction, GeneticUp-RegulationConceptsSmall nuclear RNAHSURs 1Herpesvirus saimiriNuclear RNAExpression of genesAggressive T-cell leukemiaMarmoset T cellsHSUR 1U RNAAbundant viral transcriptCell activationT cellsHost mRNAsUnexpected roleIntracellular proteinsNorthern analysisSm classHost targetsViral transcriptsT cell activationNew World primatesRNAT-cell receptor betaT-cell leukemiaGamma chain
1993
Rare scleroderma autoantibodies to the U11 small nuclear ribonucleoprotein and to the trimethylguanosine cap of U small nuclear RNAs.
Gilliam AC, Steitz JA. Rare scleroderma autoantibodies to the U11 small nuclear ribonucleoprotein and to the trimethylguanosine cap of U small nuclear RNAs. Proceedings Of The National Academy Of Sciences Of The United States Of America 1993, 90: 6781-6785. PMID: 8341699, PMCID: PMC47016, DOI: 10.1073/pnas.90.14.6781.Peer-Reviewed Original ResearchConceptsSmall nuclear ribonucleoprotein particleTrimethylguanosine capLow-abundance membersSmall nuclear RNASmall nuclear ribonucleoproteinNuclear ribonucleoprotein particleGlycerol gradient fractionsU RNAU11 small nuclear ribonucleoproteinsSnRNP complexTargeted degradationNuclear RNANuclear ribonucleoproteinRibonucleoprotein particleNuclear extractsSm classProtein componentsHeLa cellsRNPGradient fractionsRNAProteinScleroderma seraRibonucleoproteinCosediments
1989
The mammalian analogue of the yeast PRP8 splicing protein is present in the U4/5/6 small nuclear ribonucleoprotein particle and the spliceosome.
Pinto AL, Steitz JA. The mammalian analogue of the yeast PRP8 splicing protein is present in the U4/5/6 small nuclear ribonucleoprotein particle and the spliceosome. Proceedings Of The National Academy Of Sciences Of The United States Of America 1989, 86: 8742-8746. PMID: 2479028, PMCID: PMC298364, DOI: 10.1073/pnas.86.22.8742.Peer-Reviewed Original ResearchConceptsSmall nuclear ribonucleoproteinU5 small nuclear ribonucleoproteinHeLa cell nuclear extractsSmall nuclear ribonucleoprotein particleCell nuclear extractsAnti-trimethylguanosine antibodyNuclear ribonucleoprotein particleAffinity-purified spliceosomesSplicing proteinsMammalian proteinsYeast proteinsSnRNP complexMRNA splicingSplicing extractsRibonucleoprotein particleNuclear ribonucleoproteinMammalian analogueNuclear extractsSm classGradient fractionationSm epitopesProteinSpliceosomeProtein reactivePrp8
1988
Additional low-abundance human small nuclear ribonucleoproteins: U11, U12, etc.
Montzka KA, Steitz JA. Additional low-abundance human small nuclear ribonucleoproteins: U11, U12, etc. Proceedings Of The National Academy Of Sciences Of The United States Of America 1988, 85: 8885-8889. PMID: 2973606, PMCID: PMC282611, DOI: 10.1073/pnas.85.23.8885.Peer-Reviewed Original ResearchConceptsSmall nuclear ribonucleoproteinU12 small nuclear ribonucleoproteinsSm small nuclear ribonucleoproteinsTrimethylguanosine cap structureTwo-dimensional gel fractionationLow-abundance RNAsLower eukaryotesSmall RNAsMRNA processingMammalian cellsMRNA splicingNuclear ribonucleoproteinAdditional speciesCap structureNuclease sensitivityNew RNASm classSm epitopesRNAU11Gel fractionationPotential roleU12EukaryotesSplicing
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply