2025
A niche driven mechanism determines response and a mutation-independent therapeutic approach for myeloid malignancies
Mosialou I, Ali A, Labella R, Bisikirska B, Cuesta-Dominguez A, Vgenopoulou P, Reyes I, Rao S, Wang A, Luo N, Galan-Diez M, Zhao J, Chernak B, Bewersdorf J, Fukasawa K, Su J, Higa J, Adams R, Corper A, Pampou S, Woods C, Fan X, Shah R, Feldstein J, Liu N, Liang C, Heiblig M, Kornblau S, Garcia-Manero G, Berman E, Jurcic J, Rabadan R, Raza A, Kousteni S. A niche driven mechanism determines response and a mutation-independent therapeutic approach for myeloid malignancies. Cancer Cell 2025, 43: 1007-1024.e13. PMID: 40154481, PMCID: PMC12151774, DOI: 10.1016/j.ccell.2025.03.007.Peer-Reviewed Original ResearchConceptsStandard of careAcute myeloid leukemiaAll-trans-retinoic acidMyelodysplastic syndromeMyeloid malignanciesLeukemic micePatients treated with all-trans-retinoic acidMDS/AML cellsResponse to therapyResistance to standardResponse to ATRAMyeloid leukemiaTargeted therapyMyeloid cancersAssociated with activationMutation profilesTherapeutic approachesImproved efficacyDisease outcomeMiceRelapseMalignancyTherapyPatientsOsteoblastic cells
2008
Obesity Accelerates T-Cell Leukemia in a Spontaneous Mouse Model.
Yun J, Klemm L, Behan J, Müschen M, Mittelman S. Obesity Accelerates T-Cell Leukemia in a Spontaneous Mouse Model. Blood 2008, 112: 1909. DOI: 10.1182/blood.v112.11.1909.1909.Peer-Reviewed Original ResearchAKR/J miceSpontaneous T cell leukemiaT-cell leukemiaT cell maturationDiet-induced obesityJ miceOnset of leukemiaLeukemic miceDiet groupMouse modelControl dietEffect of obesityCD4/CD8Non-obese counterpartsT cell subgroupsHigh-fat dietSpontaneous mouse modelMonths of ageT cell differentiationWeeks of ageTypes of cancerCD4/ CD8Clinical illnessThymus weightLifestyle parameters
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