2024
Cell Culture Evaluation Hints Widely Available HIV Drugs Are Primed for Success if Repurposed for HTLV-1 Prevention
Kalemera M, Maher A, Dominguez-Villar M, Maertens G. Cell Culture Evaluation Hints Widely Available HIV Drugs Are Primed for Success if Repurposed for HTLV-1 Prevention. Pharmaceuticals 2024, 17: 730. PMID: 38931397, PMCID: PMC11206710, DOI: 10.3390/ph17060730.Peer-Reviewed Original ResearchAdult T-cell leukaemia/lymphomaIntegrase strand transfer inhibitorsNucleoside reverse transcriptase inhibitorsHTLV-1Reservoir of latently infected CD4+ T cellsDevelopment of adult T-cell leukaemia/lymphomaHIV-1Latently infected CD4+ T cellsHuman T-cell lymphotropic virus type 1Infected CD4+ T cellsCD4+ T cellsHTLV-1 endemic areasAssociated with poor prognosisHTLV-1-associated pathologiesAntiretroviral therapy prescriptionT-cell leukaemia/lymphomaStrand transfer inhibitorsHTLV-1 infectionHTLV-1 transmissionReverse transcriptase inhibitorsShorter overall survivalVirus type 1HIV pillsOverall survivalHIV therapyHTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP): Case based discussion of risk factors, clinical, and therapeutic considerations
Saab L, DiCapua D, Zubair A. HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP): Case based discussion of risk factors, clinical, and therapeutic considerations. Journal Of The Neurological Sciences 2024, 459: 122973. PMID: 38520941, DOI: 10.1016/j.jns.2024.122973.Peer-Reviewed Original ResearchHTLV-1-associated myelopathy/tropical spastic paraparesisMyelopathy/tropical spastic paraparesisHTLV-1Discussion of risk factorsInfected CD4+ T cellsCD4+ T cellsAdult T-cell leukemia/lymphomaSpastic paraparesisT-cell leukemia/lymphomaQuality of lifeOptimal patient outcomesHTLV-1 infectionSymptoms of weaknessManaging symptomsDuration of infectionLoss of bladder controlNonspecific symptomsT cellsLower extremitiesSensory disturbancePatient outcomesTherapeutic considerationsHAM/TSPProviral loadRisk factorsHTLV-1 induces an inflammatory CD4+CD8+ T cell population in HTLV-1–associated myelopathy
Maher A, Aristodemou A, Giang N, Tanaka Y, Bangham C, Taylor G, Dominguez-Villar M. HTLV-1 induces an inflammatory CD4+CD8+ T cell population in HTLV-1–associated myelopathy. JCI Insight 2024, 9: e173738. PMID: 38193535, PMCID: PMC10906466, DOI: 10.1172/jci.insight.173738.Peer-Reviewed Original ResearchConceptsHTLV-1-associated myelopathyDP T cellsT cellsHTLV-1Double-positive T cellsAdult T-cell leukemiaT cell populationsT-cell tropismHTLV-1 infectionHuman T-cell leukemia virus type 1Virus type 1T-cell leukemiaCXCR3 expressionPreferential CD4Asymptomatic infectionCNS pathologyIL-6Asymptomatic carriersInflammatory diseasesCytotoxic phenotypeCell leukemiaCell tropismType 1CD4Cell populations
2015
Monoclonal antibody profiling of cell surface proteins associated with the viral biofilms on HTLV-1 transformed cells.
Tarasevich A, Filatov A, Pichugin A, Mazurov D. Monoclonal antibody profiling of cell surface proteins associated with the viral biofilms on HTLV-1 transformed cells. Acta Virologica 2015, 59: 247-56. PMID: 26435148, DOI: 10.4149/av_2015_03_247.Peer-Reviewed Original ResearchConceptsViral biofilmsHTLV-1Cluster of differentiationVirological synapseHuman T-lymphotropic virus 1Cell-to-cell virus transmissionIntercellular adhesion molecule 1Upregulates intercellular adhesion molecule 1HTLV-1 infectionHTLV-1 transmissionAdhesion molecule 1HTLV-1 spreadHTLV-1-transformed cellsCell-to-cell contactAnti-CD25Viral protein TaxIL-2RAAntigens CD4ICAM-1Pathogenic retrovirusesCell surface proteinsMolecule 1Monoclonal antibodiesVB formationProtein Tax
2011
Role of O-Glycosylation and Expression of CD43 and CD45 on the Surfaces of Effector T Cells in Human T Cell Leukemia Virus Type 1 Cell-to-Cell Infection
Mazurov D, Ilinskaya A, Heidecker G, Filatov A. Role of O-Glycosylation and Expression of CD43 and CD45 on the Surfaces of Effector T Cells in Human T Cell Leukemia Virus Type 1 Cell-to-Cell Infection. Journal Of Virology 2011, 86: 2447-2458. PMID: 22171268, PMCID: PMC3302266, DOI: 10.1128/jvi.06993-11.Peer-Reviewed Original ResearchConceptsJurkat cellsVirus type 1Expression of CD43Short hairpin RNAT cellsHTLV-1O-glycosylationHIV-1O-glycan elongationType 1Human immune deficiency virus type 1Effector T cellsHIV-1 infectionHuman T-cell leukemia virus type 1Cell-to-cell infectionSurface of T cellsCell-cell contactJurkat T cellsHTLV-1 infectionHTLV-1 proteinsHTLV-1 particlesCell surface antigensChaperone CosmcInfectious structuresCosmc gene
2010
Quantitative Comparison of HTLV-1 and HIV-1 Cell-to-Cell Infection with New Replication Dependent Vectors
Mazurov D, Ilinskaya A, Heidecker G, Lloyd P, Derse D. Quantitative Comparison of HTLV-1 and HIV-1 Cell-to-Cell Infection with New Replication Dependent Vectors. PLOS Pathogens 2010, 6: e1000788. PMID: 20195464, PMCID: PMC2829072, DOI: 10.1371/journal.ppat.1000788.Peer-Reviewed Original ResearchConceptsCell-to-cell infectionEnv expression plasmidsHTLV-1 transmissionHIV-1HTLV-1Packaging vectorTarget cellsCocultured target cellsHIV-1 vectorsHIV-1 infectionHTLV-1 infectionCell-free infectionCell-cell interactionsReporter vectorInhibited HTLV-1Enhance virus infectionLymphocyte cell linesTarget cell typeHTLV-1 TaxEffector cellsReporter gene activityT cellsB cellsReporter gene expressionTime course study
2009
Early Neurologic Abnormalities Associated with Human T-Cell Lymphotropic Virus Type 1 Infection in a Cohort of Peruvian Children
Kendall EA, González E, Espinoza I, Tipismana M, Verdonck K, Clark D, Vermund SH, Gotuzzo E. Early Neurologic Abnormalities Associated with Human T-Cell Lymphotropic Virus Type 1 Infection in a Cohort of Peruvian Children. The Journal Of Pediatrics 2009, 155: 700-706. PMID: 19628219, PMCID: PMC2764792, DOI: 10.1016/j.jpeds.2009.05.027.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAge DistributionAge of OnsetCase-Control StudiesChildChild, PreschoolCohort StudiesConfidence IntervalsFemaleHTLV-I InfectionsHuman T-lymphotropic virus 1HumansInfectious Disease Transmission, VerticalMaleNeurologic ExaminationOdds RatioParaparesisParaparesis, Tropical SpasticPeruPrevalenceProbabilityRisk AssessmentSeverity of Illness IndexSex DistributionSpinal Cord DiseasesTime FactorsUrination DisordersConceptsParesthesia/dysesthesiaHTLV-1 infectionNeurologic abnormalitiesInfective dermatitisHTLV-1Lumbar painHuman T-cell lymphotropic virus type 1 infectionMyelopathy/tropical spastic paraparesisHuman T-cell lymphotropic virus type 1Virus type 1 infectionPeruvian childrenAbnormal neurologic findingsEarly Neurologic AbnormalitiesLower extremity hyperreflexiaStandardized neurologic examinationType 1 infectionTropical spastic paraparesisWeakness/fatigueHTLV-1 statusVirus type 1Uninfected childrenNeurologic findingsNeurologic symptomsUrinary disturbanceNeurologic examination
2007
Frequent HTLV-1 infection in the offspring of Peruvian women with HTLV-1-associated myelopathy/tropical spastic paraparesis or strongyloidiasis.
Gotuzzo E, Moody J, Verdonck K, Cabada MM, González E, Van Dooren S, Vandamme AM, Terashima A, Vermund SH. Frequent HTLV-1 infection in the offspring of Peruvian women with HTLV-1-associated myelopathy/tropical spastic paraparesis or strongyloidiasis. BULL PAN AM HEALTH ORGAN 2007, 22: 223-30. PMID: 18078583, DOI: 10.1590/s1020-49892007000900001.Peer-Reviewed Original ResearchConceptsHAM/TSPHTLV-1 infectionOffspring of mothersHTLV-1-associated myelopathy/tropical spastic paraparesisMyelopathy/tropical spastic paraparesisTropical spastic paraparesisSpastic paraparesisAsymptomatic motherHTLV-1Asymptomatic HTLV-1 infectionHTLV-1-positive womenMultiple logistic regression analysisHTLV-1 transmissionLogistic regression analysisDaughters of womenTransfusion historyAsymptomatic infectionMean ageHTLV infectionTime of testingRisk factorsClinical conditionsStrongyloidiasisPeruvian womenInfection
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