2024
A detox dilemma beyond benzodiazepines; clonidine's quandary in alcohol withdrawal management
Johnson M, Cosentino D, Fuehrlein B. A detox dilemma beyond benzodiazepines; clonidine's quandary in alcohol withdrawal management. American Journal On Addictions 2024, 34: 101-103. PMID: 39096168, DOI: 10.1111/ajad.13640.Peer-Reviewed Original ResearchPsychiatric emergency roomAlcohol withdrawalBenzodiazepine useAmerican Society of Addiction Medicine guidelinesTreatment of alcohol withdrawalClinical Institute Withdrawal AssessmentAWS managementAlternative agentsComorbid hypertensionEmergency roomVeterans AffairsRetrospective chart reviewWithdrawal AssessmentOpioid withdrawalBenzodiazepine doseAdjunctive medicationsAlcohol withdrawal managementBenzodiazepinesWithdrawal managementDepartment of Veterans AffairsVeteran populationClonidine useMedication dosesChart reviewSyndromic management
2019
Symptom-Triggered Therapy for Alcohol Withdrawal Syndrome: a Systematic Review and Meta-analysis of Randomized Controlled Trials
Holleck JL, Merchant N, Gunderson CG. Symptom-Triggered Therapy for Alcohol Withdrawal Syndrome: a Systematic Review and Meta-analysis of Randomized Controlled Trials. Journal Of General Internal Medicine 2019, 34: 1018-1024. PMID: 30937668, PMCID: PMC6544709, DOI: 10.1007/s11606-019-04899-7.Peer-Reviewed Original ResearchConceptsSymptom-triggered therapyDuration of therapyAlcohol withdrawal syndromeBenzodiazepine doseWithdrawal syndromeTrial of patientsLow-risk patientsGeneral hospital settingRandomized Controlled TrialsRisk of biasTerms of mortalitySystematic literature searchStrength of evidenceBenzodiazepine dosageDose therapyMedication classesCochrane RegistryCochrane riskDose regimensAlcohol withdrawalBias toolControlled TrialsDose scheduleResultsSix studiesI2 statistic
2014
Improved Analgesia, Sedation, and Delirium Protocol Associated with Decreased Duration of Delirium and Mechanical Ventilation
Dale CR, Kannas DA, Fan VS, Daniel SL, Deem S, Yanez ND, Hough CL, Dellit TH, Treggiari MM. Improved Analgesia, Sedation, and Delirium Protocol Associated with Decreased Duration of Delirium and Mechanical Ventilation. Annals Of The American Thoracic Society 2014, 11: 367-374. PMID: 24597599, PMCID: PMC4028734, DOI: 10.1513/annalsats.201306-210oc.Peer-Reviewed Original ResearchConceptsCAM-ICU assessmentsIntensive care unitMechanical ventilationMedian durationICU stayBenzodiazepine doseSedation protocolPatient assessmentBaseline cohortTrauma-surgical intensive care unitConfusion Assessment Method-ICURichmond Agitation-Sedation Scale scorePrespecified secondary endpointSedation Scale scoreDays of deliriumImproved patient outcomesMultivariable linear regressionBenzodiazepine dosingBenzodiazepine exposureDelirium protocolHospital mortalityPneumonia ratesProtocol cohortRASS assessmentsImproved analgesia
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