2024
Primary and Secondary Intracerebral Hemorrhage in Pregnant and Nonpregnant Young Adults by SMASH‐UP Criteria
Sariyeva M, Haghighi N, Mitchell A, Booker W, Petersen N, Shields A, Ghoshal S, Agarwal S, Park S, Claassen J, Connolly E, Roh D, Miller E. Primary and Secondary Intracerebral Hemorrhage in Pregnant and Nonpregnant Young Adults by SMASH‐UP Criteria. Journal Of The American Heart Association 2024, 13: e034032. PMID: 38533990, PMCID: PMC11179753, DOI: 10.1161/jaha.123.034032.Peer-Reviewed Original ResearchNonpregnant womenSecondary intracerebral hemorrhagePrimary intracerebral hemorrhageNontraumatic intracerebral hemorrhageIntracerebral hemorrhageIntracerebral hemorrhage pathogenesisIntracerebral hemorrhage characteristicsIn-hospital mortality rateYoung adultsCohort of young adultsTime of dischargeMaternal morbidityNonpregnant adultsUnique pathophysiologyRetrospective analysisFunctional outcomesOdds ratioMortality ratePathogenesisSmall vesselsWomenHemorrhageOddsPathophysiologyMen
2023
A novel human iPSC model of COL4A1/A2 small vessel disease unveils a key pathogenic role of matrix metalloproteinases
Al-Thani M, Goodwin-Trotman M, Bell S, Patel K, Fleming L, Vilain C, Abramowicz M, Allan S, Wang T, Cader M, Horsburgh K, Van Agtmael T, Sinha S, Markus H, Granata A. A novel human iPSC model of COL4A1/A2 small vessel disease unveils a key pathogenic role of matrix metalloproteinases. Stem Cell Reports 2023, 18: 2386-2399. PMID: 37977146, PMCID: PMC10724071, DOI: 10.1016/j.stemcr.2023.10.014.Peer-Reviewed Original ResearchConceptsSmall vessel diseaseMatrix metalloproteinasesVessel diseaseCerebral small vessel diseaseKey pathogenic roleEndothelial cell tight junctionsHuman iPSC modelSVD pathologyCo-culture modelLeading causePathogenic roleCell phenotypic changesExtracellular matrixParacrine actionCell tight junctionsMMP activityTherapeutic opportunitiesECM abnormalitiesCell defectsEndothelial cellsMural cellsSmall vesselsTight junctionsIPSC modelsDisease
2018
Frequent GNAQ and GNA14 Mutations in Hepatic Small Vessel Neoplasm
Joseph NM, Brunt EM, Marginean C, Nalbantoglu I, Snover DC, Thung SN, Yeh MM, Umetsu SE, Ferrell LD, Gill RM. Frequent GNAQ and GNA14 Mutations in Hepatic Small Vessel Neoplasm. The American Journal Of Surgical Pathology 2018, 42: 1201-1207. PMID: 29975248, DOI: 10.1097/pas.0000000000001110.Peer-Reviewed Original ResearchConceptsHepatic small vessel neoplasmVariant lesionsGNA14 mutationsVascular neoplasmLow-grade vascular neoplasmLow-grade neoplasmsVascular lesionsCavernous hemangiomaInfiltrative natureCytologic atypiaMolecular pathogenesisNeoplasmsPanel sequencingCopy number alterationsHotspot mutationsExome sequencingLesionsPathogenic mutationsSmall vesselsGNAQSame missense mutationNumber alterationsLiverMissense mutationsMutations
2013
Burden of Blood Pressure–Related Alleles Is Associated With Larger Hematoma Volume and Worse Outcome in Intracerebral Hemorrhage
Falcone GJ, Biffi A, Devan WJ, Brouwers HB, Anderson CD, Valant V, Ayres AM, Schwab K, Rost NS, Goldstein JN, Viswanathan A, Greenberg SM, Selim M, Meschia JF, Brown DL, Worrall BB, Silliman SL, Tirschwell DL, Rosand J, Investigators O. Burden of Blood Pressure–Related Alleles Is Associated With Larger Hematoma Volume and Worse Outcome in Intracerebral Hemorrhage. Stroke 2013, 44: 321-326. PMID: 23321443, PMCID: PMC3560332, DOI: 10.1161/strokeaha.112.675181.Peer-Reviewed Original ResearchConceptsPoor clinical outcomeBaseline hematoma volumeIntracerebral hemorrhageClinical outcomesHematoma volumeGenetic risk scoreBlood pressureICH volumeRisk scoreHypertension-related end-organ damageRisk of ICHAdmission ICH volumeEnd-organ damageLarger hematoma volumeSupratentorial intracerebral hemorrhageHigh blood pressureCerebral small vesselsDeep intracerebral hemorrhageSmall vesselsSingle nucleotide polymorphismsMultivariate regression analysisProgressive diseaseProspective studyAcute manifestationsWorse outcomes
2012
Cine computed tomography angiography evaluation of blood flow for full face transplant surgical planning.
Sisk G, Kumamaru K, Schultz K, Bueno E, Diaz-Siso J, George E, Redjaee M, Mitsouras D, Steigner M, Pomahac B, Rybicki F. Cine computed tomography angiography evaluation of blood flow for full face transplant surgical planning. Eplasty 2012, 12: e57. PMID: 23308304, PMCID: PMC3531245.Peer-Reviewed Original ResearchVascular mappingBlood flowComprehensive vascular assessmentTomography angiography evaluationPreoperative vascular mappingCine loopsFull face transplantationAngiography evaluationCarotid distributionTransplantation candidatesVascular assessmentArterial fillingVenous anastomosisDiagnostic findingsVenous phaseMajor vesselsPreoperative planningSurgical planningFace transplantationPlastic surgeonsSmall vesselsContrast enhancementCineTomographic imagingVessels
2011
Impact of Lesion Length and Vessel Size on Clinical Outcomes After Percutaneous Coronary Intervention With Everolimus- Versus Paclitaxel-Eluting Stents Pooled Analysis From the SPIRIT (Clinical Evaluation of the XIENCE V Everolimus Eluting Coronary Stent System) and COMPARE (Second-generation everolimus-eluting and paclitaxel-eluting stents in real-life practice) Randomized Trials
Claessen BE, Smits PC, Kereiakes DJ, Parise H, Fahy M, Kedhi E, Serruys PW, Lansky AJ, Cristea E, Sudhir K, Sood P, Simonton CA, Stone GW. Impact of Lesion Length and Vessel Size on Clinical Outcomes After Percutaneous Coronary Intervention With Everolimus- Versus Paclitaxel-Eluting Stents Pooled Analysis From the SPIRIT (Clinical Evaluation of the XIENCE V Everolimus Eluting Coronary Stent System) and COMPARE (Second-generation everolimus-eluting and paclitaxel-eluting stents in real-life practice) Randomized Trials. JACC Cardiovascular Interventions 2011, 4: 1209-1215. PMID: 22115661, DOI: 10.1016/j.jcin.2011.07.016.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngioplasty, Balloon, CoronaryCardiovascular AgentsChi-Square DistributionCoronary AngiographyCoronary StenosisDrug-Eluting StentsEverolimusFemaleHumansKaplan-Meier EstimateMaleMiddle AgedMyocardial InfarctionPaclitaxelPredictive Value of TestsProportional Hazards ModelsProsthesis DesignRandomized Controlled Trials as TopicRisk AssessmentRisk FactorsSeverity of Illness IndexSirolimusThrombosisTime FactorsTreatment OutcomeConceptsMajor adverse cardiac eventsPaclitaxel-eluting stentsReference vessel diameterEverolimus-eluting stentsPercutaneous coronary interventionLong lesionsGroup BLesion lengthMACE rateCoronary interventionSmall vesselsGroup AStent typeShort lesionsAdverse cardiac eventsHigh-risk patientsPatient-level dataLarge vesselsLower ratesCOMPARE trialLesion revascularizationEfficacy outcomesAdverse eventsCardiac eventsIndependent predictors
2008
Stents auto-expansíveis versus balão-expansíveis para tratamento de lesões em vasos de fino calibre: estudo com ultra-som intracoronário tridimensional
Chamié D, Costa J, Abizaid A, Feres F, Devito F, Mattos L, Staico R, Abizaid A, Tanajura L, Fitzgerald P, Whitbourn R, Sousa A, Sousa J. Stents auto-expansíveis versus balão-expansíveis para tratamento de lesões em vasos de fino calibre: estudo com ultra-som intracoronário tridimensional. Journal Of Transcatheter Interventions 2008, 16: 341-352. DOI: 10.1590/s2179-83972008000300017.Peer-Reviewed Original ResearchMonths of follow-upSmall vesselsAssociated with poor short-Less vessel injuryIntravascular ultrasoundNeointimal hyperplasiaLong-term outcomesVolumetric intravascular ultrasoundPercutaneous coronary interventionRate of restenosisBalloon-expandable stentsSelf-expanding stentsMechanical propertiesHistorical cohortPoor short-Mean ageFollow-upTreatment of SVCoronary interventionIn-stentVessel injuryInclusion criteriaStentLuminal areaLuminal volume
2003
Optimal final lumen area and predictors of target lesion revascularization after stent implantation in small coronary arteries
Iakovou I, Mintz GS, Dangas G, Abizaid A, Mehran R, Lansky AJ, Kobayashi Y, Hirose M, Ashby DT, Stone GW, Moses JW, Leon MB. Optimal final lumen area and predictors of target lesion revascularization after stent implantation in small coronary arteries. The American Journal Of Cardiology 2003, 92: 1171-1176. PMID: 14609591, DOI: 10.1016/j.amjcard.2003.07.025.Peer-Reviewed Original ResearchConceptsTarget lesion revascularizationGreater stent expansionSmall coronary arteriesCoronary arteryLesion revascularizationTLR rateStent implantationStent areaSmall vesselsPredictors of TLRAngiographic reference vessel diameterGroup IStent expansionLumen areaHigher TLR rateGroup II patientsBaseline patient characteristicsReference vessel diameterPrior myocardial infarctionEarly clinical eventsReference vessel areaFinal lumen areaHospital outcomesClinical restenosisPatient characteristics
2002
Coronary heart disease stenting in small vessels versus balloon angloplasty study (CHIVAS): a randomized prospective multicenter trial
Muramatsu T, Iwasaki K, Inoue N, Horita Y, Tanaka T, Fujita N, Kamiya H, Namura M, Awano K, Murakami M, Ozaki Y, Lansky A. Coronary heart disease stenting in small vessels versus balloon angloplasty study (CHIVAS): a randomized prospective multicenter trial. Journal Of The American College Of Cardiology 2002, 39: 50. DOI: 10.1016/s0735-1097(02)80217-0.Peer-Reviewed Original Research
2000
Relation of coronary artery size to one-year clinical events after new device angioplasty of native coronary arteries (a New Approach to Coronary Intervention [NACI] Registry report)
Saucedo J, Popma J, Kennard E, Talley J, Lansky A, Leon M, Baim D, Investigators F. Relation of coronary artery size to one-year clinical events after new device angioplasty of native coronary arteries (a New Approach to Coronary Intervention [NACI] Registry report). The American Journal Of Cardiology 2000, 85: 166-171. PMID: 10955371, DOI: 10.1016/s0002-9149(99)00649-9.Peer-Reviewed Original ResearchConceptsReference vessel diameterNew device angioplastyNative coronary arteriesMinimal lumen diameterClinical eventsAngiographic outcomesCoronary arteryFinal minimal lumen diameterFinal percent diameter stenosisMajor adverse clinical eventsOne-year clinical eventsSmaller reference vessel diameterBaseline lesion characteristicsRisk of TLRCombined end pointAdverse clinical eventsCoronary artery diseaseCoronary Intervention RegistryEarly clinical eventsIncidence of deathSmall vesselsCoronary artery sizePercent diameter stenosisLesion revascularizationMultivessel disease
1996
Contemporary stent designs: Technical considerations, complications, role of intravascular ultrasound, and anticoagulation therapy
Popma J, Lansky A, Ito S, Mintz G, Leon M. Contemporary stent designs: Technical considerations, complications, role of intravascular ultrasound, and anticoagulation therapy. Progress In Cardiovascular Diseases 1996, 39: 111-128. PMID: 8841006, DOI: 10.1016/s0033-0620(96)80021-1.Peer-Reviewed Original ResearchConceptsBalloon angioplastyIntravascular ultrasoundSaphenous vein graft diseaseClinical useLate clinical benefitNative coronary arteriesVein graft diseaseStent designCurrent antiplateletAnticoagulation therapyAntithrombotic therapyGraft diseaseAdjunct therapyClinical benefitCoronary arteryStent placementDiffuse diseaseStent useBifurcation stenosisTherapySmall vesselsAngioplastyComplicationsNumber of studiesDisease
1995
Southwestern Internal Medicine Conference: Vasculitis—It’s Time To Reclassify
Alpern R. Southwestern Internal Medicine Conference: Vasculitis—It’s Time To Reclassify. The American Journal Of The Medical Sciences 1995, 309: 235-248. PMID: 7900748, DOI: 10.1097/00000441-199504000-00010.Peer-Reviewed Original ResearchConceptsCytoplasmic antibodiesCrescentic glomerulonephritisAnti-neutrophil cytoplasmic antibodiesAnti-myeloperoxidase antibodiesSmall vessel vasculitisSmall vesselsP-ANCAPulse steroidsC-ANCAMost patientsRenal biopsyVessel vasculitisPathophysiologic mechanismsPathologic confirmationMedium arteriesLarge arteriesVasculitisCombination of treatmentsCytotoxic agentsAntibodiesVasculitidesGlomerulonephritisArterySteroidsTreatment
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