2024
Predicting positive Clostridioides difficile test results using large-scale longitudinal data of demographics and medication history
Pham A, El-Kareh R, Myers F, Ohno-Machado L, Kuo T. Predicting positive Clostridioides difficile test results using large-scale longitudinal data of demographics and medication history. Heliyon 2024, 11: e41350. PMID: 39958729, PMCID: PMC11825254, DOI: 10.1016/j.heliyon.2024.e41350.Peer-Reviewed Original ResearchArea under the receiver operating characteristic curveMedical historyClostridioides difficile</i> infectionMonths of medical historyPatient's chancesData of demographicsReceiver operating characteristic curveLogistic regression modelsHealth patientsModerate sample sizesPregnant womenHealthcare institutionsClostridioides difficile</i>Antibiotic useOdds ratioNegative casesLarge-scale longitudinal dataFinancial incentivesPositive testLogistic regressionPatientsIncreased susceptibilityCharacteristic curveRegression modelsSignificant covariates
2021
Population pharmacokinetics of cyclophosphamide and 4-hydroxycyclophosphamide metabolite in patients with autoimmune glomerulonephritis
Iliopoulou VN, Charkoftaki G, Cooper JC, Dokoumetzidis A, Joy MS. Population pharmacokinetics of cyclophosphamide and 4-hydroxycyclophosphamide metabolite in patients with autoimmune glomerulonephritis. Journal Of Pharmacy And Pharmacology 2021, 73: 1683-1692. PMID: 34480477, DOI: 10.1093/jpp/rgab135.Peer-Reviewed Original ResearchConceptsPopulation pharmacokinetic modelPharmacokinetic modelAutoimmune glomerulonephritisCentral volumeSimultaneous population pharmacokinetic modelInitiation of therapyVisual predictive checkProportional error modelElimination rate constantDose regimensPopulation pharmacokineticsTotal clearancePatient variablesPlasma concentrationsCyclophosphamidePharmacokinetic evaluationPharmacokinetic parametersPatientsPlasma samplingPotential covariatesGlomerulonephritisSignificant covariatesPredictive checksFinal modelCovariatesUtilization of Electroconvulsive Therapy for Older Homeless Adults Covered by Medicare
Wilkinson ST, Rhee TG, Tsai J. Utilization of Electroconvulsive Therapy for Older Homeless Adults Covered by Medicare. Psychiatric Quarterly 2021, 92: 1825-1837. PMID: 34468909, DOI: 10.1007/s11126-021-09946-3.Peer-Reviewed Original ResearchConceptsElectroconvulsive therapyOlder Medicare beneficiariesECT useMedicare beneficiariesOutpatient electroconvulsive therapyMajor depressive disorderLower odds ratioHomeless individualsOlder homeless adultsECT coursePsychiatric comorbidityUnadjusted ratesOutpatient settingDepressive disorderOdds ratioNon-homeless individualsHomeless patientsPsychosocial supportSociodemographic characteristicsSignificant covariatesOlder homeless individualsHomeless adultsTherapyLower ratesHomeless group
2014
Impact of Financial Burden of Cancer on Survivors' Quality of Life
Fenn KM, Evans SB, McCorkle R, DiGiovanna MP, Pusztai L, Sanft T, Hofstatter EW, Killelea BK, Knobf MT, Lannin DR, Abu-Khalaf M, Horowitz NR, Chagpar AB. Impact of Financial Burden of Cancer on Survivors' Quality of Life. JCO Oncology Practice 2014, 10: 332-338. PMID: 24865220, DOI: 10.1200/jop.2013.001322.Peer-Reviewed Original ResearchConceptsQuality of lifeNational Health Interview SurveyStrong independent predictorCancer care costsIndependent predictorsCancer survivorsCare costsHealth Interview SurveyFinancial burdenPopulation-based sampleMultivariable regression modelsMultivariable analysisSurvivors' qualityPatientsBivariate analysisCancerSignificant covariatesMental healthPhysical healthInterview SurveyEmotional healthFinancial problemsSurvivorsPoor qualityRegression models
2012
Population Pharmacokinetics and Pharmacodynamics of Piperaquine in Children With Uncomplicated Falciparum Malaria
Tarning J, Zongo I, Somé FA, Rouamba N, Parikh S, Rosenthal PJ, Hanpithakpong W, Jongrak N, Day NP, White NJ, Nosten F, Ouedraogo J, Lindegardh N. Population Pharmacokinetics and Pharmacodynamics of Piperaquine in Children With Uncomplicated Falciparum Malaria. Clinical Pharmacology & Therapeutics 2012, 91: 497-505. PMID: 22258469, PMCID: PMC3736305, DOI: 10.1038/clpt.2011.254.Peer-Reviewed Original ResearchConceptsUncomplicated falciparum malariaFalciparum malariaPopulation pharmacokineticsThree-compartment distribution modelNonlinear mixed-effects modelingRecurrent malaria infectionsTotal piperaquine exposureArtemisinin combination treatmentWeight-normalized dosePlasma concentration-time profilesYoung childrenMixed-effects modelingConcentration-time profilesPiperaquine concentrationsPiperaquine exposureDose regimenMalaria infectionPlasma concentrationsPharmacodynamic propertiesCombination treatmentBody weightPiperaquineSignificant covariatesOlder childrenMalaria
2006
Genetic Susceptibility to Retinopathy of Prematurity
Bizzarro MJ, Hussain N, Jonsson B, Feng R, Ment LR, Gruen JR, Zhang H, Bhandari V. Genetic Susceptibility to Retinopathy of Prematurity. 2006, 118: 1858-1863. PMID: 17079555, DOI: 10.1542/peds.2006-1088.Peer-Reviewed Original ResearchConceptsRetinopathy of prematuritySupplemental oxygen useLogistic regression analysisGestational ageOxygen useGenetic susceptibilityDuration of ventilationRespiratory distress syndromeLength of stayMixed-effects logistic regression analysisStrong genetic predispositionRegression analysisBronchopulmonary dysplasiaDistress syndromePostmenstrual ageRetrospective studyBirth weightPediatric ophthalmologistsPremature twinsPrematurityRetinopathyGenetic predispositionSignificant covariatesDizygotic twin pairsZygosity data
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