2024
SWI/SNF Complex-Deficient Undifferentiated Carcinoma of the Pancreas: Clinicopathologic and Genomic Analysis
Yavas A, Ozcan K, Adsay N, Balci S, Tarcan Z, Hechtman J, Luchini C, Scarpa A, Lawlor R, Mafficini A, Reid M, Xue Y, Yang Z, Haye K, Bellizzi A, Vanoli A, Benhamida J, Balachandran V, Jarnagin W, Park W, O'Reilly E, Klimstra D, Basturk O. SWI/SNF Complex-Deficient Undifferentiated Carcinoma of the Pancreas: Clinicopathologic and Genomic Analysis. Modern Pathology 2024, 37: 100585. PMID: 39094734, PMCID: PMC11585460, DOI: 10.1016/j.modpat.2024.100585.Peer-Reviewed Original ResearchConceptsPancreatic ductal adenocarcinomaUndifferentiated carcinomaConventional pancreatic ductal adenocarcinomaSMARCB1 protein expressionPancreatic undifferentiated carcinomaProtein expressionPD-L1SMARCB1 deletionRhabdoid morphologyPD-L1 protein expressionCase of undifferentiated carcinomaNext-generation sequencingCombined positive scoreLoss of SMARCB1 protein expressionKRAS wild typeNegative prognostic impactChromatin remodeling complex subunitMultiple tumor typesPrognostic impactTumor characteristicsOverall survivalSWI/SNF deficiencyTumor groupGene alterationsInactivating alterations
2023
Cholangiocarcinoma: Pathologic and Molecular Classification in the Era of Precision Medicine.
Gopal P, Robert M, Zhang X. Cholangiocarcinoma: Pathologic and Molecular Classification in the Era of Precision Medicine. Archives Of Pathology & Laboratory Medicine 2023, 148: 359-370. PMID: 37327187, DOI: 10.5858/arpa.2022-0537-ra.Peer-Reviewed Original ResearchConceptsDiagnosis of cholangiocarcinomaImmune checkpoint inhibitorsAdvanced tumor stageHeterogeneous tumor groupTumor growth patternEra of precision medicineTherapeutic decision-makingEvaluation of cholangiocarcinomaExtrahepatic biliary treeGenetic testing methodologiesSite of originCheckpoint inhibitorsTumor inaccessibilityMetastatic adenocarcinomaPeriductal infiltrationTumor stageIntraductal tumorClinical presentationDifferentiate cholangiocarcinomaImmunohistochemical profileTumor groupExtrahepatic cholangiocarcinomaTargeted therapyPathological diagnosisIntrahepatic cholangiocarcinoma
2022
Joint EANM/SIOPE/RAPNO practice guidelines/SNMMI procedure standards for imaging of paediatric gliomas using PET with radiolabelled amino acids and [18F]FDG: version 1.0
Piccardo A, Albert N, Borgwardt L, Fahey F, Hargrave D, Galldiks N, Jehanno N, Kurch L, Law I, Lim R, Lopci E, Marner L, Morana G, Young Poussaint T, Seghers V, Shulkin B, Warren K, Traub-Weidinger T, Zucchetta P. Joint EANM/SIOPE/RAPNO practice guidelines/SNMMI procedure standards for imaging of paediatric gliomas using PET with radiolabelled amino acids and [18F]FDG: version 1.0. European Journal Of Nuclear Medicine And Molecular Imaging 2022, 49: 3852-3869. PMID: 35536420, PMCID: PMC9399211, DOI: 10.1007/s00259-022-05817-6.Peer-Reviewed Original ResearchConceptsAmino acid positron emission tomographyPositron emission tomographyPaediatric neuro-oncologyEuropean Society for Paediatric Oncology (SIOPENeuro-oncologyLevel of evidenceBrain tumor groupPositron emission tomography imagingEvidence-based recommendationsPaediatric patientsTumor groupResponse assessmentClinician guidelinesPaediatric gliomasBrain gliomasImaging specialistsEmission tomographyRadiolabeled amino acidsConsensus opinionEANMPaediatric oncologyPET radiopharmaceuticalsGliomaNuclear medicineOncology
2021
Tumor location and reduction in functional MRI estimates of language laterality
Połczyńska MM, Beck L, Kuhn T, Benjamin CF, Ly TK, Japardi K, Cavanagh L, Bookheimer SY. Tumor location and reduction in functional MRI estimates of language laterality. Journal Of Neurosurgery 2021, 135: 1674-1684. PMID: 33799298, PMCID: PMC8909357, DOI: 10.3171/2020.9.jns202036.Peer-Reviewed Original ResearchRight hemisphere tumorsAnterior tumorsHemisphere tumorsLaterality indexLanguage lateralityBroca's areaFMRI laterality indicesLeft hemisphere tumorsPosterior ROIsWhole-brain levelPosterior tumorsTumor locationTumor resectionPreoperative fMRIInferior frontal gyrusTumor groupLanguage cortexBrain tumorsPatientsNumerous confoundersTumor hemisphereConfoundersRegion of interestLeft inferior frontal gyrusTumors
2018
[Clinical features and surgical treatment of neurilemmoma versus carotid body tumors at bifurcation of carotid artery].
Shao H, Liu F, Zhang W, Wang L, Chen B, Jiang J, Dong Z, Shi Y, Guo D, Fu W. [Clinical features and surgical treatment of neurilemmoma versus carotid body tumors at bifurcation of carotid artery]. Journal Of Zhejiang University (Medical Sciences) 2018, 47: 583-587. PMID: 30900834, PMCID: PMC10393715, DOI: 10.3785/j.issn.1008-9292.2018.12.03.Peer-Reviewed Original ResearchConceptsCarotid body tumorBody tumorsBifurcation of carotid arteriesTumor groupOperative timeIntra-operative blood lossZhongshan Hospital of Fudan UniversityIncidence of peri-operative complicationsCarotid arteryLength of hospital stayCarotid artery resectionIncidence of malignancyPeri-operative complicationsCarotid artery bifurcationClinical demographic dataArtery resectionResection rateSurgical resectionTumor sizeArtery bifurcationBlood lossZhongshan HospitalClinicopathological characteristicsNo significant differenceSurgical treatmentMagnetic Resonance Imaging of Tumor-Associated Macrophages: Clinical Translation
Aghighi M, Theruvath AJ, Pareek A, Pisani LL, Alford R, Muehe AM, Sethi TK, Holdsworth SJ, Hazard FK, Gratzinger D, Luna-Fineman S, Advani R, Spunt SL, Daldrup-Link HE. Magnetic Resonance Imaging of Tumor-Associated Macrophages: Clinical Translation. Clinical Cancer Research 2018, 24: 4110-4118. PMID: 29764855, PMCID: PMC6125171, DOI: 10.1158/1078-0432.ccr-18-0673.Peer-Reviewed Original ResearchConceptsBone sarcomasClinical trialsFerumoxytol-enhanced MRIImmune-targeted therapiesProspective clinical trialsYoung adult patientsDensity of CD68Biopsy/resectionClin Cancer ResTumor biopsy/resectionInstitutional review boardNoninvasive imaging techniquesPrecontrast scansTAM densityAdult patientsPilot patientsPediatric patientsPostcontrast MRIPostcontrast scansCancer immunotherapyMacrophage stainingTumor responseMRI 24Tumor groupMalignant tumors
2011
Frequency and Outcomes of Hyperlactatemia After Neurosurgery
Kohli-Seth R, Mukkera S, Leibowitz A, Nemani N, Oropello J, Manasia A, Bassily-Marcus A, Benjamin E. Frequency and Outcomes of Hyperlactatemia After Neurosurgery. ICU Director 2011, 2: 211-214. DOI: 10.1177/1944451611424486.Peer-Reviewed Original ResearchSerum lactate levelsSurgery groupSerum lactateIntracranial vascular surgeryLactate levelsSpinal surgery groupElevated serum lactateNeurosurgical intensive care unitIncidence of hyperlactatemiaAssociated with survivalTertiary care hospitalIntensive care unitBrain tumor groupVascular surgery groupPatients admitted to neurosurgical intensive care unitLength of stayPostoperative hyperlactatemiaSpinal surgeryTumor groupRetrospective analysisVascular surgeryCare unitBrain tumorsNeurosurgical patientsPatients
1999
Immunohistochemical comparison of cutaneous lymphadenoma, trichoblastoma, and basal cell carcinoma: support for classification of lymphadenoma as a variant of trichoblastoma
McNiff J, Eisen R, Glusac E. Immunohistochemical comparison of cutaneous lymphadenoma, trichoblastoma, and basal cell carcinoma: support for classification of lymphadenoma as a variant of trichoblastoma. Journal Of Cutaneous Pathology 1999, 26: 119-124. PMID: 10235376, DOI: 10.1111/j.1600-0560.1999.tb01815.x.Peer-Reviewed Original ResearchConceptsBasal cell carcinomaVariant of trichoblastomaCutaneous lymphadenomaCell carcinomaLangerhans cellsNodular basal cell carcinomaCK20-positive Merkel cellsS100-positive cellsBcl-2CD30-positive cellsCharacteristic immunohistochemical findingsSimilar staining patternLymphoid infiltratesImmunohistochemical findingsStromal stainingTumor groupEpithelial tumorsImmunohistochemical comparisonUncertain histogenesisMerkel cellsTrichoblastomaS100 proteinCD1aLymphadenomaStaining pattern
1984
Biochemical and Histomorphometric Characterization of a Rat Model for Humoral Hypercalcemia of Malignancy*
INSOGNA K, STEWART A, VIGNERY A, WEIR E, NAMNUM P, BARON R, KIRKWOOD J, DEFTOS L, BROADUS A. Biochemical and Histomorphometric Characterization of a Rat Model for Humoral Hypercalcemia of Malignancy*. Endocrinology 1984, 114: 888-896. PMID: 6546543, DOI: 10.1210/endo-114-3-888.Peer-Reviewed Original ResearchConceptsTumor-bearing animalsBone-resorbing activityHumoral hypercalcemiaDay 13Dihydroxyvitamin D valuesFractional phosphorus excretionQuantitative bone histomorphometryAction of PTHImmunoreactive PTH levelsTumor-bearing groupLeydig cell tumorMale Fisher ratsBone cell functionPTH levelsNephrogenous cAMPDihydroxyvitamin DTumor transplantationCell tumorsBone resorptionBone histomorphometryRat modelTumor groupControl animalsFisher ratsMarked suppression
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