2024
A machine-learning approach for differentiating borderline personality disorder from community participants with brain-wide functional connectivity
Lahnakoski J, Nolte T, Solway A, Vilares I, Hula A, Feigenbaum J, Lohrenz T, King-Casas B, Fonagy P, Montague P, Schilbach L. A machine-learning approach for differentiating borderline personality disorder from community participants with brain-wide functional connectivity. Journal Of Affective Disorders 2024, 360: 345-353. PMID: 38806064, DOI: 10.1016/j.jad.2024.05.125.Peer-Reviewed Original ResearchBorderline personality disorderPrediction of borderline personality disorderFunctional connectivityPersonality disorderBorderline personality disorder patientsBorderline personality disorder statusBrain-wide functional connectivityBiomarkers of psychiatric disordersFunctional connectivity markersFunctional connectivity patternsSelf-reported resultsClinical InterviewPsychiatric disordersSomatomotor regionsChance levelSeed ROIConnectivity markersComparison correctionSeed regionConnectivity patternsDiscrimination performanceConnectivity valuesDisordersBorderlineGeneralizability
2023
Anti-seed PNAs targeting multiple oncomiRs for brain tumor therapy
Wang Y, Malik S, Suh H, Xiao Y, Deng Y, Fan R, Huttner A, Bindra R, Singh V, Saltzman W, Bahal R. Anti-seed PNAs targeting multiple oncomiRs for brain tumor therapy. Science Advances 2023, 9: eabq7459. PMID: 36753549, PMCID: PMC9908025, DOI: 10.1126/sciadv.abq7459.Peer-Reviewed Original ResearchConceptsConvection-enhanced deliveryHigh recurrence rateOrthotopic mouse modelBrain tumor therapyTreatment of glioblastomaRecurrence ratePoor survivalLethal malignancyMouse modelGBM progressionTumor cellsGlioblastomaTumor therapyBioadhesive nanoparticlesOncomiRSurvivalTreatmentSeed regionMalignancyTemozolomideTherapy
2020
Resting-state neural signatures of depressive symptoms in acute HIV
Philippi CL, Reyna L, Nedderman L, Chan P, Samboju V, Chang K, Phanuphak N, Ratnaratorn N, Hellmuth J, Benjapornpong K, Dumrongpisutikul N, Pothisri M, Robb ML, Ananworanich J, Spudich S, Valcour V, Paul R. Resting-state neural signatures of depressive symptoms in acute HIV. Journal Of NeuroVirology 2020, 26: 226-240. PMID: 31989446, PMCID: PMC7261250, DOI: 10.1007/s13365-020-00826-3.Peer-Reviewed Original ResearchConceptsResting-state functional connectivityAcute HIV infectionAnterior cingulate cortexDecreased resting-state functional connectivityDepressive symptomsAltered Resting-State Functional ConnectivityCombination antiretroviral therapyPersistent depressive symptomsUninfected control groupAmygdala seed regionPosterior cingulate/precuneusSymptoms of depressionVoxelwise regression analysesEmotion-related brain regionsAcute HIVChronic HIVThai HIVAntiretroviral therapyHIV RNASeed regionHIV infectionBlood biomarkersAHI groupLateral parietal regionsUninfected controls
2019
Stepwise functional connectivity reveals altered sensory‐multimodal integration in medication‐naïve adults with attention deficit hyperactivity disorder
Pretus C, Marcos‐Vidal L, Martínez‐García M, Picado M, Ramos‐Quiroga J, Richarte V, Castellanos F, Sepulcre J, Desco M, Vilarroya Ó, Carmona S. Stepwise functional connectivity reveals altered sensory‐multimodal integration in medication‐naïve adults with attention deficit hyperactivity disorder. Human Brain Mapping 2019, 40: 4645-4656. PMID: 31322305, PMCID: PMC6865796, DOI: 10.1002/hbm.24727.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderFunctional connectivitySensory regionsNeural hubCognitive functionResting-state functional magnetic resonance imagingAttention deficit hyperactivity disorderFunctional magnetic resonance imagingSeed regionPatterns of functional connectivityDefault-mode networkDeficit hyperactivity disorderFunctional networksPrimary sensory regionsFunctional overconnectivityAttention-deficit/hyperactivityNeuroimaging studiesMode networkHyperactivity disorderLow connectivity degreeRs-fMRIPattern of alterationsSeverity ScaleSensory inputMagnetic resonance imaging
2018
Adaptation of brain functional stream architecture in athletes with fast demands of sensorimotor integration
Gao Q, Yu Y, Su X, Tao Z, Zhang M, Wang Y, Leng J, Sepulcre J, Chen H. Adaptation of brain functional stream architecture in athletes with fast demands of sensorimotor integration. Human Brain Mapping 2018, 40: 420-431. PMID: 30277624, PMCID: PMC6865555, DOI: 10.1002/hbm.24382.Peer-Reviewed Original ResearchConceptsDorsal attention networkSkills trainingAttention Network TestGray matter volumeVoxel-based morphometryTraining-induced neuroplasticityStudent-athletesReaction timeOrienting attentionRight sensorimotor areaMatter volumeNeuroplastic adaptationsNetwork TestMotor skill trainingConnectivity changesLimbic lobeAttention subnetworkDMNSeed regionAttention networkSensorimotor areasHuman brainNeuronal circuitsConnection distanceConnectivity streams
2017
Functional connectivity in resting state as a phonemic fluency ability measure
Miró-Padilla A, Bueichekú E, Ventura-Campos N, Palomar-García M, Ávila C. Functional connectivity in resting state as a phonemic fluency ability measure. Neuropsychologia 2017, 97: 98-103. PMID: 28202336, DOI: 10.1016/j.neuropsychologia.2017.02.009.Peer-Reviewed Original ResearchConceptsFunctional connectivityFAS testPhonemic fluencyRight insulaLeft inferior frontal gyrusMeasures of phonemic fluencyResting-state FC analysisInferior frontal gyrusAssociated with better performanceLower functional connectivityFrontal gyrusBrain areasCognitive abilitiesAttentional factorsFC patternsBehavioral testsReactivity hypothesisResting-stateMotor areaAbility measuresFC analysisSeed regionHigher FCInsulaFluency
2016
The Effects of Methylphenidate on Resting-State Functional Connectivity of the Basal Nucleus of Meynert, Locus Coeruleus, and Ventral Tegmental Area in Healthy Adults
Kline RL, Zhang S, Farr OM, Hu S, Zaborszky L, Samanez-Larkin GR, Li CS. The Effects of Methylphenidate on Resting-State Functional Connectivity of the Basal Nucleus of Meynert, Locus Coeruleus, and Ventral Tegmental Area in Healthy Adults. Frontiers In Human Neuroscience 2016, 10: 149. PMID: 27148006, PMCID: PMC4834346, DOI: 10.3389/fnhum.2016.00149.Peer-Reviewed Original ResearchResting-state functional connectivityEffects of methylphenidateAttention deficit hyperactivity disorderLocus coeruleusPositive connectivityNegative connectivityFunctional connectivityBrain resting-state functional connectivityHealthy adultsDeficit hyperactivity disorderBasal nucleusDose of methylphenidateMiddle occipital gyrusSeed regionVTA/SNcVentral tegmental area/substantia nigraCognitive controlVentral tegmental areaHyperactivity disorderOccipital gyrusT-testCatecholaminergic signalingTwo-sample t-testMethylphenidatePrecentral gyrus
2012
Functional connectivity studies of patients with auditory verbal hallucinations
Hoffman RE, Hampson M. Functional connectivity studies of patients with auditory verbal hallucinations. Frontiers In Human Neuroscience 2012, 6: 6. PMID: 22375109, PMCID: PMC3269039, DOI: 10.3389/fnhum.2012.00006.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsAuditory verbal hallucinationsFunctional connectivity studiesFC studiesWernicke's areaVerbal hallucinationsConnectivity studiesLeft inferior frontal cortexInferior frontal cortexMagnetic resonance imaging dataFrontal cortexCorticostriatal loopsSeed regionPutamenFMRI dataAuditory stimuliRight homologueFunctional magnetic resonance imaging (fMRI) dataIntact FcHallucinationsPatientsBrain mechanismsNeural synchronizationFuture studiesHyperconnectivitySame subjects
2011
A whole-brain voxel based measure of intrinsic connectivity contrast reveals local changes in tissue connectivity with anesthetic without a priori assumptions on thresholds or regions of interest
Martuzzi R, Ramani R, Qiu M, Shen X, Papademetris X, Constable RT. A whole-brain voxel based measure of intrinsic connectivity contrast reveals local changes in tissue connectivity with anesthetic without a priori assumptions on thresholds or regions of interest. NeuroImage 2011, 58: 1044-1050. PMID: 21763437, PMCID: PMC3183817, DOI: 10.1016/j.neuroimage.2011.06.075.Peer-Reviewed Original ResearchConceptsIntrinsic connectivity contrastBrain circuitsFunctional connectivity fMRISpontaneous fluctuationsFunctional magnetic resonance imaging (fMRI) signalsWhole-brain voxelDifferent brain circuitsConnectivity analysisMagnetic resonance imaging signalsSevoflurane anesthesiaIntrinsic connectivityIndividual tissue elementsICC analysisICC measuresRegion of interestTissue elementsFMRI signalsBrainNon-invasive mannerFunctional organizationImaging signalsSeed regionSingle seed regionTissue connectivityPrevious studiesResting-State Functional Connectivity of the Medial Superior Frontal Cortex
Zhang S, Ide JS, Li CS. Resting-State Functional Connectivity of the Medial Superior Frontal Cortex. Cerebral Cortex 2011, 22: 99-111. PMID: 21572088, PMCID: PMC3236794, DOI: 10.1093/cercor/bhr088.Peer-Reviewed Original ResearchConceptsMedial superior frontal cortexSupplementary motor areaSuperior frontal cortexFunctional connectivityFrontal cortexMotor areaResting-state functional magnetic resonanceResting-state functional connectivityFrontal cortical functionPresupplementary motor areaFunctional magnetic resonanceSubthalamic nucleusSomatomotor areasCortical functionPreSMAAnterior partSignificant hemispheric asymmetryCaudateBehavioral tasksAnatomical boundariesCortexFuture studiesHemispheric asymmetryMagnetic resonanceSeed region
2010
Elevated Functional Connectivity Along a Corticostriatal Loop and the Mechanism of Auditory/Verbal Hallucinations in Patients with Schizophrenia
Hoffman RE, Fernandez T, Pittman B, Hampson M. Elevated Functional Connectivity Along a Corticostriatal Loop and the Mechanism of Auditory/Verbal Hallucinations in Patients with Schizophrenia. Biological Psychiatry 2010, 69: 407-414. PMID: 21145042, PMCID: PMC3039042, DOI: 10.1016/j.biopsych.2010.09.050.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlgorithmsAntipsychotic AgentsCerebral CortexDiagnostic and Statistical Manual of Mental DisordersFemaleFrontal LobeHallucinationsHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleNeostriatumNeural PathwaysNeuropsychological TestsPutamenSchizophreniaSchizophrenic PsychologySocioeconomic FactorsTemporal LobeVerbal BehaviorConceptsHealthy control subjectsControl subjectsFunctional connectivityNonhallucinating patientsPatient groupInferior frontal gyrusAuditory/verbal hallucinationsCorticostriatal loopsElevated functional connectivityVerbal hallucinationsFalse discovery rate correctionFunctional magnetic resonancePatientsSubcortical regionsLeft inferior frontal gyrusSeed regionPutamenFrontal gyrusSpeech processing networkFunctional coordinationNeural activitySchizophreniaFC relativeHigh levelsHallucinationsA Variant in a MicroRNA complementary site in the 3′ UTR of the KIT oncogene increases risk of acral melanoma
Godshalk SE, Paranjape T, Nallur S, Speed W, Chan E, Molinaro AM, Bacchiocchi A, Hoyt K, Tworkoski K, Stern DF, Sznol M, Ariyan S, Lazova R, Halaban R, Kidd KK, Weidhaas JB, Slack FJ. A Variant in a MicroRNA complementary site in the 3′ UTR of the KIT oncogene increases risk of acral melanoma. Oncogene 2010, 30: 1542-1550. PMID: 21119596, PMCID: PMC3069149, DOI: 10.1038/onc.2010.536.Peer-Reviewed Original ResearchConceptsMessenger RNAsComplementary sitesNovel genetic markersKIT oncogeneTarget genesRegulatory relationshipsUntranslated regionGenetic markersHeritable riskFunctional variantsGenetic variantsOncogeneMultifaceted roleProtein levelsProtein expressionVariant resultsComplementary sequencesReporter dataUTRMelanoma pathogenesisMiR-221KIT variantsSeed regionExpressionVariants
2009
A neural measure of behavioral engagement: Task-residual low-frequency blood oxygenation level-dependent activity in the precuneus
Zhang S, Li CS. A neural measure of behavioral engagement: Task-residual low-frequency blood oxygenation level-dependent activity in the precuneus. NeuroImage 2009, 49: 1911-1918. PMID: 19761851, PMCID: PMC2791356, DOI: 10.1016/j.neuroimage.2009.09.004.Peer-Reviewed Original ResearchConceptsBlood oxygenation level-dependent activityRegional brain activationLevel-dependent activityTask engagementNeural measuresNeural processesBrain activationPosterior cingulate cortexAttentional monitoringResponse inhibitionHuman cognitionPrefrontal activationSignal taskGreater activationBOLD activityBehavioral engagementCingulate cortexPrecuneusBrain regionsLow-frequency fluctuationsFractional amplitudeBrain imagingSeed regionIndependent component analysisEngagement
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