2016
A Tunable Mechanism Determines the Duration of the Transgenerational Small RNA Inheritance in C. elegans
Houri-Ze'evi L, Korem Y, Sheftel H, Faigenbloom L, Toker I, Dagan Y, Awad L, Degani L, Alon U, Rechavi O. A Tunable Mechanism Determines the Duration of the Transgenerational Small RNA Inheritance in C. elegans. Cell 2016, 165: 88-99. PMID: 27015309, DOI: 10.1016/j.cell.2016.02.057.Peer-Reviewed Original ResearchConceptsAncestral responsesSmall RNAsC. elegansRNAi responseEndogenous small RNAsSilencing of genesRNA sequencing analysisRNA inheritanceHeritable silencingRNAi factorsExposure to dsRNAManipulating genesEpigenetic responsesComplementary sequencesEpigenetic effectsGenesRNAiTransgenerational effectsSilencingRNAFeedback loopInheritance mechanismDsRNAElegansAncestor
2012
Does Lin28 Antagonize miRNA-Mediated Repression by Displacing miRISC from Target mRNAs?
Kallen AN, Ma J, Huang Y. Does Lin28 Antagonize miRNA-Mediated Repression by Displacing miRISC from Target mRNAs? Frontiers In Genetics 2012, 3: 240. PMID: 23162570, PMCID: PMC3499807, DOI: 10.3389/fgene.2012.00240.Peer-Reviewed Original ResearchRNA helicase ARibonucleoprotein complexesDEAD-box protein familyMiRNA-mediated repressionATP-dependent unwindingTranslation of genesStimulation of translationFamily of miRNAsSubset of miRNAsRNA helicasesProtein familyTarget mRNAsSame mRNAGene expressionPleiotropic rolesLin28Mode of actionRNA duplexesCell growthNeuronal cellsMiRNAsMRNAComplementary sequencesBrain synaptic functionSynaptic function
2010
Innate Immunity to Viruses
Iwasaki A. Innate Immunity to Viruses. 2010, 183-196. DOI: 10.1128/9781555816872.ch15.Peer-Reviewed Original ResearchDNA virusesEndosomal trafficking eventsHost cell machineryMechanism of RNAiAbsence of VpuInnate immunityTrafficking eventsEndonuclease familyCell machineryCytoplasmic DNAE3 ubiquitinLipid raftsCaspase-1 inflammasomeAnalysis of animalCell surfaceViral dsRNADistinct rolesNeighboring cellsAntiviral stateBillions of yearsLike receptorsI IFN productionComplementary sequencesViral RNARNAA Variant in a MicroRNA complementary site in the 3′ UTR of the KIT oncogene increases risk of acral melanoma
Godshalk SE, Paranjape T, Nallur S, Speed W, Chan E, Molinaro AM, Bacchiocchi A, Hoyt K, Tworkoski K, Stern DF, Sznol M, Ariyan S, Lazova R, Halaban R, Kidd KK, Weidhaas JB, Slack FJ. A Variant in a MicroRNA complementary site in the 3′ UTR of the KIT oncogene increases risk of acral melanoma. Oncogene 2010, 30: 1542-1550. PMID: 21119596, PMCID: PMC3069149, DOI: 10.1038/onc.2010.536.Peer-Reviewed Original ResearchConceptsMessenger RNAsComplementary sitesNovel genetic markersKIT oncogeneTarget genesRegulatory relationshipsUntranslated regionGenetic markersHeritable riskFunctional variantsGenetic variantsOncogeneMultifaceted roleProtein levelsProtein expressionVariant resultsComplementary sequencesReporter dataUTRMelanoma pathogenesisMiR-221KIT variantsSeed regionExpressionVariants
1996
The U18 snRNA is not essential for pre-rRNA processing in Xenopus laevis.
Dunbar D, Ware V, Baserga S. The U18 snRNA is not essential for pre-rRNA processing in Xenopus laevis. RNA 1996, 2: 324-33. PMID: 8634913, PMCID: PMC1369375.Peer-Reviewed Original Research
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