2021
Increased Alpha-Band Connectivity During Tic Suppression in Children With Tourette Syndrome Revealed by Source Electroencephalography Analyses
Morand-Beaulieu S, Wu J, Mayes LC, Grantz H, Leckman JF, Crowley MJ, Sukhodolsky DG. Increased Alpha-Band Connectivity During Tic Suppression in Children With Tourette Syndrome Revealed by Source Electroencephalography Analyses. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2021, 8: 241-250. PMID: 33991741, PMCID: PMC8589865, DOI: 10.1016/j.bpsc.2021.05.001.Peer-Reviewed Original ResearchConceptsTourette syndromeTic suppressionNetwork-based statisticsDefault mode networkCortical regionsRight superior frontal gyrusMode networkAge-mediated increaseFuture treatment studiesSuperior frontal gyrusAlpha-band connectivityChronic motorHigh-density electroencephalographyPhonic ticsLeft precuneusCortical areasBrain regionsTreatment studiesBrain circuitsFunctional connectivityBrain connectivityFrontal gyrusGraph theoretical analysisNeurodevelopmental disordersBrain correlates
2020
Botulinum Toxin for the Treatment of Motor and Phonic Tics: A Case Report
Kohli N, Blitzer A. Botulinum Toxin for the Treatment of Motor and Phonic Tics: A Case Report. Annals Of Otology Rhinology & Laryngology 2020, 129: 625-627. PMID: 31906695, DOI: 10.1177/0003489419898211.Peer-Reviewed Original ResearchConceptsYale Global Tic Severity ScaleTreatment of motorPhonic ticsCase reportTic Severity ScaleFacial mimetic musculatureOnabotulinum toxinFiberoptic visualizationBotulinum toxinThroat clearingTic disordersSeverity ScaleTic severityObjective decreaseMimetic musculaturePatientsTreatmentLevel VExperienced reductionsMusculatureToxinReportGruntingBoNTSeverity
2012
Clinical assessment of Tourette syndrome and tic disorders
Cohen SC, Leckman JF, Bloch MH. Clinical assessment of Tourette syndrome and tic disorders. Neuroscience & Biobehavioral Reviews 2012, 37: 997-1007. PMID: 23206664, PMCID: PMC3674220, DOI: 10.1016/j.neubiorev.2012.11.013.Peer-Reviewed Original ResearchConceptsTourette syndromeAttention deficit hyperactivity disorderObsessive-compulsive disorderTreatment of TSImpaired sensorimotor gatingPercent of childrenImpulse control disordersDeficit hyperactivity disorderSomatic hypersensitivityTic symptomsPhonic ticsPurposeless movementsTic disordersClinical assessmentSensorimotor gatingControl disordersProper diagnosisMuscle groupsPremonitory urgesNeuropsychiatric disordersHyperactivity disorderDisordersAppropriate evaluationSyndromeSensory phenomena
2006
Adulthood Outcome of Tic and Obsessive-Compulsive Symptom Severity in Children With Tourette Syndrome
Bloch MH, Peterson BS, Scahill L, Otka J, Katsovich L, Zhang H, Leckman JF. Adulthood Outcome of Tic and Obsessive-Compulsive Symptom Severity in Children With Tourette Syndrome. JAMA Pediatrics 2006, 160: 65-69. PMID: 16389213, PMCID: PMC2291298, DOI: 10.1001/archpedi.160.1.65.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdrenergic alpha-AgonistsAdultAntipsychotic AgentsAttention Deficit Disorder with HyperactivityBipolar DisorderChildDepressive DisorderFemaleFollow-Up StudiesHumansIntelligence TestsMaleObsessive-Compulsive DisorderProspective StudiesSchizophreniaSelective Serotonin Reuptake InhibitorsSeverity of Illness IndexTic DisordersTourette SyndromeConceptsTic symptomsTourette syndromeTic severitySymptom severityObsessive-compulsive disorderBaseline clinical measurementsChildhood-onset neuropsychiatric disorderOCD symptomsPercent of patientsProspective cohort studyPercent of subjectsOutpatient specialty clinicsThird of childrenThird of adultsAge 14 yearsStructured clinical evaluationCohort studyClinical courseComplete resolutionClinical evaluationPhonic ticsSpecialty clinicFollow-up interviewObsessive-compulsive symptom severityAverage age
2005
Tourette’s Syndrome and Tic Disorders
Swain J, King R, Leckman J. Tourette’s Syndrome and Tic Disorders. Current Clinical Neurology 2005, 151-169. DOI: 10.1385/1-59259-856-0:151.Peer-Reviewed Original Research
1995
Guanfacine Treatment of Comorbid Attention-Deficit Hyperactivity Disorder and Tourette's Syndrome: Preliminary Clinical Experience
CHAPPELL P, RIDDLE M, SCAHILL L, LYNCH K, SCHULTZ R, ARNSTEN A, LECKMAN J, COHEN D. Guanfacine Treatment of Comorbid Attention-Deficit Hyperactivity Disorder and Tourette's Syndrome: Preliminary Clinical Experience. Journal Of The American Academy Of Child & Adolescent Psychiatry 1995, 34: 1140-1146. PMID: 7559307, DOI: 10.1097/00004583-199509000-00010.Peer-Reviewed Original ResearchConceptsYale Global Tic Severity ScaleAttention deficit hyperactivity disorderTourette syndromeContinuous Performance TestHyperactivity disorderOpen-label studyCommon side effectsSeverity of motorComorbid attention deficit hyperactivity disorderSafe alternative therapySignificant decreaseTic Severity ScalePreliminary clinical experienceMajority of subjectsConners' Parent Rating ScaleTransient sedationControlled TrialsAlternative therapiesSedative effectsGuanfacine treatmentPhonic ticsSeverity ScaleSide effectsStimulant medicationTic severity
1994
Enhanced stress responsivity of tourette syndrome patients undergoing lumbar puncture
Chappell P, Riddle M, Anderson G, Scahill L, Hardin M, Walker D, Cohen D, Leckman J. Enhanced stress responsivity of tourette syndrome patients undergoing lumbar puncture. Biological Psychiatry 1994, 36: 35-43. PMID: 8080901, DOI: 10.1016/0006-3223(94)90060-4.Peer-Reviewed Original ResearchConceptsTS patientsLumbar punctureNormal controlsTourette syndromeClinician ratingsEnhanced stress responsivityLumbar puncture stressUrinary norepinephrine excretionTourette syndrome patientsPeak ACTH levelsNorepinephrine excretionACTH levelsSympathetic systemAdrenal axisMedication responsivenessMore norepinephrinePhonic ticsSyndrome patientsUrinary catecholaminesMore ACTHPatientsTic severityNeuropsychiatric disordersSymptom severityStress responsivity
1993
Neuroendocrine and behavioral effects of the selective kappa agonist spiradoline in Tourette's syndrome: A pilot study
Chappell P, Leckman J, Scahill L, Hardin M, Anderson G, Cohen D. Neuroendocrine and behavioral effects of the selective kappa agonist spiradoline in Tourette's syndrome: A pilot study. Psychiatry Research 1993, 47: 267-280. PMID: 8396784, DOI: 10.1016/0165-1781(93)90084-t.Peer-Reviewed Original ResearchConceptsNormal control subjectsTourette syndromeTic frequencyControl subjectsTS patientsMicrograms/Clinician ratingsKappa agonist spiradolineInvolvement of opioidRole of opioidsGrowth hormone secretionDual modulatory effectsDose-response studyMotor tic frequencyMore growth hormoneTic symptomsHormone secretionNeuroendocrine effectsKappa receptorsPhonic ticsSpiradoline mesylateIntermediate doseLow doseModulatory effectsSpiradoline
1986
The Pathogenesis of Tourette Syndrome
Leckman J, Cohen D, Price R, Riddle M, Minderaa R, Anderson G, Pauls D. The Pathogenesis of Tourette Syndrome. 1986, 257-272. DOI: 10.1007/978-1-4684-5038-5_14.Peer-Reviewed Original Research
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply