2022
MFN2 Deficiency Impairs Mitochondrial Functions and PPAR Pathway During Spermatogenesis and Meiosis in Mice
Wang T, Xiao Y, Hu Z, Gu J, Hua R, Hai Z, Chen X, Zhang J, Yu Z, Wu T, Yeung W, Liu K, Guo C. MFN2 Deficiency Impairs Mitochondrial Functions and PPAR Pathway During Spermatogenesis and Meiosis in Mice. Frontiers In Cell And Developmental Biology 2022, 10: 862506. PMID: 35493072, PMCID: PMC9046932, DOI: 10.3389/fcell.2022.862506.Peer-Reviewed Original ResearchConditional knock-outMitochondrial functionPPAR pathwayMale germ cellsRNA-seq analysisGenes up-regulatedGenes down-regulatedPathway enrichment analysisImpaired mitochondrial functionDynamic organellesMitochondrial dynamicsRNA-seqMitochondrial fusionDisrupted spermatogenesisMfn2 deficiencyGerm cellsPachytene stageOxidative phosphorylationSpermatogenesisTranscriptome profilingEnrichment analysisMfn2Cellular differentiationMolecular mechanismsLipid droplets
2011
Pinpointing the expression of piRNAs and function of the PIWI protein subfamily during spermatogenesis in the mouse
Beyret E, Lin H. Pinpointing the expression of piRNAs and function of the PIWI protein subfamily during spermatogenesis in the mouse. Developmental Biology 2011, 355: 215-226. PMID: 21539824, PMCID: PMC3443393, DOI: 10.1016/j.ydbio.2011.04.021.Peer-Reviewed Original ResearchConceptsPIWI proteinsXY bodyMouse testisAdult mouse testisEarly round spermatidsSex chromosomesGenomic sequencesPiRNAsChromatoid bodyCytological characterizationPachytene stageGerm cellsPhenotypic analysisAdult testisRound spermatidsProteinMeiosisSpermatogenesisCytoplasmDense bodiesSpermatocytesTestisPiRNAChromosomesTransposon
1988
Meiotic expression of human ornithine transcarbamylase in the testes of transgenic mice.
Kelley K, Chamberlain J, Nolan J, Horwich A, Kalousek F, Eisenstadt J, Herrup K, Rosenberg L. Meiotic expression of human ornithine transcarbamylase in the testes of transgenic mice. Molecular And Cellular Biology 1988, 8: 1821-1825. PMID: 2837657, PMCID: PMC363346, DOI: 10.1128/mcb.8.4.1821.Peer-Reviewed Original ResearchConceptsHuman ornithine transcarbamylaseFusion geneBase pairsProtein-coding sequencesMale germ cellsOrnithine transcarbamylaseMeiotic expressionRegulatory sequencesRegulatory regionsTransgenic micePachytene stageMouse metallothioneinTransgenic animalsGerm cellsGenesKilobasesTransgene expressionSequenceExpressionTranscarbamylaseMeiosisTetraploidMeiotic Expression of Human Ornithine Transcarbamylase in the Testes of Transgenic Mice
Kelley K, Chamberlain J, Nolan J, Horwich A, Kalousek F, Eisenstadt J, Herrup K, Rosenberg L. Meiotic Expression of Human Ornithine Transcarbamylase in the Testes of Transgenic Mice. Molecular And Cellular Biology 1988, 8: 1821-1825. DOI: 10.1128/mcb.8.4.1821-1825.1988.Peer-Reviewed Original ResearchHuman ornithine transcarbamylaseFusion geneBase pairsProtein-coding sequencesMale germ cellsOrnithine transcarbamylaseMeiotic expressionRegulatory sequencesRegulatory regionsTransgenic micePachytene stageMouse metallothioneinTransgenic animalsGerm cellsGenesKilobasesTransgene expressionSequenceExpressionTranscarbamylaseMeiosisTetraploid
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