2023
Inositol hexakisphosphate kinase 1 is essential for cell junction integrity in the mouse seminiferous epithelium
Bhat S, Malla A, Oddi V, Sen J, Bhandari R. Inositol hexakisphosphate kinase 1 is essential for cell junction integrity in the mouse seminiferous epithelium. Biochimica Et Biophysica Acta (BBA) - Molecular Cell Research 2023, 1871: 119596. PMID: 37742721, DOI: 10.1016/j.bbamcr.2023.119596.Peer-Reviewed Original ResearchConceptsBlood-testis barrierSeminiferous epitheliumBlood-testis barrier disruptionMouse seminiferous epitheliumCell adhesionGerm cell adhesionActin-based cytoskeletonInositol hexakisphosphate kinase 1Inositol hexakisphosphate kinasesGerm cell lossDownregulation of transcriptsMammalian testisKnockout miceRound spermatidsSertoli cellsSubcellular mislocalizationCofilin dephosphorylationIntegrin signalingMouse testisTight junction protein claudin-3Transcriptional misregulationGap junction protein connexinCell junction integrityIP6K1Junction protein connexin
2017
IP6K1 is essential for chromatoid body formation and temporal regulation of Tnp2 and Prm2 expression in mouse spermatids
Malla A, Bhandari R. IP6K1 is essential for chromatoid body formation and temporal regulation of Tnp2 and Prm2 expression in mouse spermatids. Journal Of Cell Science 2017, 130: 2854-2866. PMID: 28743739, DOI: 10.1242/jcs.204966.Peer-Reviewed Original ResearchConceptsRound spermatidsTemporal regulationMale germ cell differentiationDeletion of IP6K1Associated First Person interviewGerm cell differentiationRNA-binding proteinsInositol hexakisphosphate kinasesFirst Person interviewRegulate several physiological processesSomatic histonesSpermatid differentiationSpermatid elongationMouse testisPachytene spermatocytesMouse spermatidsChromatoid bodyChromatin componentsPRM2 expressionTranslational derepressionSpermatidsAberrant localisationIP6K1Body formationPremature expression
2016
Inositol hexakisphosphate kinase 1 (IP6K1) activity is required for cytoplasmic dynein-driven transport
Chanduri M, Rai A, Malla A, Wu M, Fiedler D, Mallik R, Bhandari R. Inositol hexakisphosphate kinase 1 (IP6K1) activity is required for cytoplasmic dynein-driven transport. Biochemical Journal 2016, 473: 3031-3047. PMID: 27474409, PMCID: PMC5095903, DOI: 10.1042/bcj20160610.Peer-Reviewed Original ResearchConceptsInositol pyrophosphatesP150(Glued) subunit of dynactinIntermediate chainEukaryotic signaling moleculesRecruitment to membranesDynein intermediate chainP150(Glued) subunitSubunit of dynactinInositol hexakisphosphate kinase 1Inositol hexakisphosphate kinasesSerine pyrophosphorylationEndosomal sortingGolgi maintenanceVesicle transportTrafficking pathwaysVesicle movementDynein functionProtein functionMammalian cellsDiphosphoinositol pentakisphosphateDisplay defectsN-terminusRegulatory signalsMonophosphate moietyMicrotubule transport
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