SIMCAP (Surgery in Metastatic Carcinoma of Prostate): Phase 2.5 Multi-Institution Randomized Prospective Clinical Trial Evaluating the Impact of Cytoreductive Radical Prostatectomy Combined With Best Systemic Therapy on Oncologic and Quality of Life Outcomes in Men With Newly Diagnosed Metastatic Prostate Cancer
Volunteers
Health Professionals
What is the purpose of this trial?
This randomized phase II trial studies how well surgical removal of the prostate and antiandrogen therapy with or without docetaxel work in treating men with newly diagnosed prostate cancer that has spread to other places in the body. Androgens can cause the growth of prostate cancer cells. Antiandrogen therapy may lessen the amount of androgens made by the body. Drugs used in chemotherapy, such as docetaxel work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Surgery, antiandrogen therapy and docetaxel may work better in treating participants with prostate cancer.
- Trial withYale Cancer Center
- Ages18 years and older
- GenderMale only
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Principal Investigator
Sub-Investigators
- Agatha Hecht
- Alessia Donadio, MD
- Anca Bulgaru, MD
- Andrea Brennan
- Armand Russo, MD
- Ashita Talsania, MRCP, MBBS
- Benjamin Newton, MD
- Beverly Drucker, MD, PhD
- Brooke Chaves
- Catherine Wei, MD
- Clarice Grens
- D. Barry Boyd, MD, MS
- Daniel P. Petrylak, MD
- Elan Gorshein, DO, JD, MPH
- Emily Kopas, APRN, OCN
- Harold Tara Jr, MD
- Jane Kanowitz, MD
- Jason Haldas, MD
- Jeremy Kortmansky, MD
- Johanna LaSala, MD
- Joseph Kim, MD
- Joseph Renzulli, MD, FACS
- Justin Persico, MD
- Karen Ann Hammond, DNP, APRN, ACNP (BC)
- Karishma Mehra, MBBS
- Katherine Harvey, MD, MPH
- Kathleen Fenn, MD
- Kayla Martello
- Kelsey Martin, MD
- Kert Sabbath, MD, FACP
- Kristen Hoxie
- Larisa Fleysher
- Lynn Mastrianni
- M. Sung Lee, MD
- Madeline Santiago
- Matthew Austin, MD
- Meaghan Conway
- Michael Burke
- Michael Cohenuram, MD
- Michael Hurwitz, MD, PhD
- Michael S. Leapman, MD, MHS
- Michelle Laspino
- Neal Fischbach, MD
- Osarugue Otasowie
- Pawan Karanam, MD
- Preston C. Sprenkle, MD
- Robert Legare, MD
- Robert Matera, MD
- Sara Anastasio, RN
- Sarah Carlson
- Sarah Thomen, APRN
- Stephen Lattanzi, MD
- Sudhanshu Mulay, MD
- Syed Ali
- Vanna Dest
- Victor Chang, MD
- Vidya Kesavan
- Virginia Syombathy
- Wajih Kidwai, MD, FACP
- Zia Rahman, MD
- Last Updated01/05/2025
- Study HIC#2000031290