2024
DPP8/9 inhibition attenuates the TGF-β1-induced excessive deposition of extracellular matrix (ECM) in human mesangial cells via Smad and Akt signaling pathways
Li K, Zhang Y, Zhao W, Wang R, Li Y, Wei L, Wang L, Chen X, Chen Z, Liu P, Nie N, Tian X, Fu R. DPP8/9 inhibition attenuates the TGF-β1-induced excessive deposition of extracellular matrix (ECM) in human mesangial cells via Smad and Akt signaling pathways. Toxicology Letters 2024, 395: 1-10. PMID: 38458339, DOI: 10.1016/j.toxlet.2024.03.001.Peer-Reviewed Original ResearchHuman mesangial cellsAkt signaling pathwayExtracellular matrixSignaling pathwayDipeptidyl peptidase IVMesangial cellsExpression of ECM-related proteinsPhosphorylation of AktECM-related proteinsAbnormal extracellular matrixECM depositionExcessive deposition of extracellular matrixPhosphorylation of Smad2DPP8/9 inhibitionDeposition of extracellular matrixGlomerular mesangial cellsDPP9Collagen IVDPP8AktMultiple diseasesDPP8/9SiRNAPathogenesis of glomerular diseaseCells
2021
New Insights into the Immunity and Podocyte in Glomerular Health and Disease: From Pathogenesis to Therapy in Proteinuric Kidney Disease
Medina Rangel P, Priyadarshini A, Tian X. New Insights into the Immunity and Podocyte in Glomerular Health and Disease: From Pathogenesis to Therapy in Proteinuric Kidney Disease. Integrative Medicine In Nephrology And Andrology 2021, 8: 5. DOI: 10.4103/imna.imna_26_21.Peer-Reviewed Original ResearchProteinuric kidney diseaseKidney diseaseGlomerular injuryPodocyte injuryChronic kidney diseaseMillions of patientsAdaptive immune systemGlomerular filtration barrierImmune cellsImmune mechanismsTherapeutic implicationsTherapeutic targetGlomerular healthImmune systemInjuryComplement componentsDiseaseEpithelial cellsPodocytesFiltration barrierPresent reviewRecent findingsRecent studiesCellsPatients