2024
Serum neuroactive metabolites of the tryptophan pathway in patients with acute phase of affective disorders
Li Y, Wang L, Huang J, Zhang P, Zhou Y, Tong J, Chen W, Gou M, Tian B, Li W, Luo X, Tian L, Hong L, Li C, Tan Y. Serum neuroactive metabolites of the tryptophan pathway in patients with acute phase of affective disorders. Frontiers In Psychiatry 2024, 15: 1357293. PMID: 38680780, PMCID: PMC11046465, DOI: 10.3389/fpsyt.2024.1357293.Peer-Reviewed Original ResearchYoung Mania Rating ScaleBD-DAffective disordersBD-MDepressive symptomsHamilton Depression Scale-17 itemsRemission of depressive symptomsKynurenic acidMania Rating ScaleAcute manic episodeWeeks of antidepressantsRisk of MDDKynurenine pathwayAssociated with remissionAntipsychotic medicationDisrupt tryptophan metabolismManic symptomsDepressive disorderBD-D.Depressive episodeHAMD-17Mood stabilizersManic episodesBipolar disorderTryptophan pathway
2020
Hippocampus and cognitive domain deficits in treatment-resistant schizophrenia: A comparison with matched treatment-responsive patients and healthy controls✰,✰✰,★,★★
Huang J, Zhu Y, Fan F, Chen S, Hong Y, Cui Y, Luo X, Tan S, Wang Z, Shang L, Yuan Y, Zhang J, Yang F, Li CR, Rowland LM, Kochunov P, Zhang F, Hong LE, Tan Y. Hippocampus and cognitive domain deficits in treatment-resistant schizophrenia: A comparison with matched treatment-responsive patients and healthy controls✰,✰✰,★,★★. Psychiatry Research Neuroimaging 2020, 297: 111043. PMID: 32062167, PMCID: PMC7490244, DOI: 10.1016/j.pscychresns.2020.111043.Peer-Reviewed Original ResearchTreatment-resistant schizophreniaTreatment-responsive patientsHippocampal volumeHealthy controlsSmaller total hippocampal volumesSmaller hippocampal volumesTotal hippocampal volumeAvailable antipsychotic medicationsSevere cognitive dysfunctionLogistic regression analysisSubgroup of schizophreniaGlobal cognitive deficitsCognitive domain deficitsSpecific deficitsAntipsychotic medicationCognitive dysfunctionTreatment resistanceHigh riskHC groupPatientsMemory deficitsCognitive deficitsCognitive functionSchizophreniaSignificant deficits