2024
Folate metabolism and risk of childhood acute lymphoblastic leukemia: a genetic pathway analysis from the Childhood Cancer and Leukemia International Consortium
Metayer C, Spector L, Scheurer M, Jeon S, Scott R, Takagi M, Clavel J, Manabe A, Ma X, Hailu E, Lupo P, Urayama K, Bonaventure A, Kato M, Meirhaeghe A, Chiang C, Morimoto L, Wiemels J. Folate metabolism and risk of childhood acute lymphoblastic leukemia: a genetic pathway analysis from the Childhood Cancer and Leukemia International Consortium. Cancer Epidemiology Biomarkers & Prevention 2024, 33: 1248-1252. PMID: 38904462, PMCID: PMC11369612, DOI: 10.1158/1055-9965.epi-24-0189.Peer-Reviewed Original ResearchSingle nucleotide polymorphismsGenome-wide dataAncestry groupsFolate metabolic pathwayGenetic variantsChildhood cancerMetabolic pathwaysGenetic pathway analysisRisk of childhood ALLRisk of childhood acute lymphoblastic leukemiaGene-folate interactionsChildhood ALL riskCase-control studyDNA methylationMETAL softwareGenetic studiesNucleotide polymorphismsPathway analysisMeta-analysis of original dataALL riskGenetic effectsAncestryFolate pathwayMaternal genetic effectsFolate intake
2022
International patterns and trends of childhood and adolescent cancer, 1978-2012
Zhao Y, Sun P, Xiao J, Jin L, Ma N, Li Z, Feng G, Huang H, Deziel N, Ma X, Ni X, Zhang Y. International patterns and trends of childhood and adolescent cancer, 1978-2012. Journal Of The National Cancer Center 2022, 2: 78-89. PMID: 39034956, PMCID: PMC11256536, DOI: 10.1016/j.jncc.2022.02.001.Peer-Reviewed Original ResearchCancer incidence ratesIncidence rateCancer incidenceMalignant central nervous system tumorsCentral nervous system tumorsOverall childhood cancerIncidence of lymphomaNervous system tumorsLeukemia incidence ratesSystem tumorsTesticular cancerChildhood cancerThyroid cancerAdolescent cancerKidney cancerJoinpoint regressionCancer incidentsAge groupsCancerCancer typesIncidenceTemporal trendsMethods DataAdolescentsChildren
2020
Socioeconomic status and childhood central nervous system tumors in California
Francis SS, Wang R, Enders C, Prado I, Wiemels JL, Ma X, Metayer C. Socioeconomic status and childhood central nervous system tumors in California. Cancer Causes & Control 2020, 32: 27-39. PMID: 33113073, DOI: 10.1007/s10552-020-01348-3.Peer-Reviewed Original ResearchConceptsPrimary CNS tumorsCentral nervous system tumorsChildhood CNS tumorsCNS tumorsNervous system tumorsSocioeconomic statusSystem tumorsChildhood central nervous system tumorsCalifornia Cancer RegistryCalifornia birth recordsSubset of subjectsHigher socioeconomic statusCancer RegistryCancer mortalitySubgroup analysisRisk factorsChildhood cancerSubsequent riskEmbryonal tumorsParental socioeconomic statusInsurance utilizationBirth recordsTumorsMedian household incomeSpecific exposuresAge-, sex- and disease subtype–related foetal growth differentials in childhood acute myeloid leukaemia risk: A Childhood Leukemia International Consortium analysis
Karalexi MA, Dessypris N, Ma X, Spector LG, Marcotte E, Clavel J, Pombo-de-Oliveira MS, Heck JE, Roman E, Mueller BA, Hansen J, Auvinen A, Lee PC, Schüz J, Magnani C, Mora AM, Dockerty JD, Scheurer ME, Wang R, Bonaventure A, Kane E, Doody DR, Group N, Baka M, Moschovi M, Polychronopoulou S, Kourti M, Hatzipantelis E, Pelagiadis I, Dana H, Kantzanou M, Tzanoudaki M, Anastasiou T, Grenzelia M, Gavriilaki E, Sakellari I, Anagnostopoulos A, Kitra V, Paisiou A, Bouka E, Group F, Nikkilä A, Lohi O, Erdmann F, Kang A, Metayer C, Milne E, Petridou E. Age-, sex- and disease subtype–related foetal growth differentials in childhood acute myeloid leukaemia risk: A Childhood Leukemia International Consortium analysis. European Journal Of Cancer 2020, 130: 1-11. PMID: 32163883, DOI: 10.1016/j.ejca.2020.01.018.Peer-Reviewed Original ResearchConceptsAcute myeloid leukemiaChildhood Leukemia International ConsortiumGestational ageFoetal growthInfant boyAcute myeloid leukemia riskMyeloid leukemia riskNewborn Growth ConsortiumRare childhood cancerBirth lengthGrowth markersChildhood cancerAML subtypesAML casesMyeloid leukemiaLeukemia riskNull associationDisease subtypesInternational FetalAgeMore studiesConsortium analysisLeukemiaSexBoysSpatial-Temporal Cluster Analysis of Childhood Cancer in California.
Francis SS, Enders C, Hyde R, Gao X, Wang R, Ma X, Wiemels JL, Selvin S, Metayer C. Spatial-Temporal Cluster Analysis of Childhood Cancer in California. Epidemiology 2020, 31: 214-223. PMID: 31596791, PMCID: PMC9005107, DOI: 10.1097/ede.0000000000001121.Peer-Reviewed Original ResearchConceptsMalignant gonadal germ cell tumorsGonadal germ cell tumorsGerm cell tumorsAcute lymphoblastic leukemiaChildhood cancerCell tumorsChildhood acute lymphoblastic leukemiaYears of ageRace/ethnicity-matched controlsEthnicity-matched controlsSpace-time cluster analysisEpidemiologic featuresHodgkin's lymphomaLymphoblastic leukemiaBirth addressHealth professionalsCancerSpace-time clustersTumorsAgeSaTScanTemporal cluster analysisFurther researchEvidenceLymphoma
2019
Parental age and the risk of childhood acute myeloid leukemia: results from the Childhood Leukemia International Consortium
Panagopoulou P, Skalkidou A, Marcotte E, Erdmann F, Ma X, Heck JE, Auvinen A, Mueller BA, Spector LG, Roman E, Metayer C, Magnani C, Pombo-de-Oliveira MS, Scheurer ME, Mora AM, Dockerty JD, Hansen J, Kang AY, Wang R, Doody DR, Kane E, Schüz J, Christodoulakis C, Ntzani E, Petridou ET, group F, group N. Parental age and the risk of childhood acute myeloid leukemia: results from the Childhood Leukemia International Consortium. Cancer Epidemiology 2019, 59: 158-165. PMID: 30776582, PMCID: PMC7098424, DOI: 10.1016/j.canep.2019.01.022.Peer-Reviewed Original ResearchConceptsChildhood Leukemia International ConsortiumAcute myeloid leukemiaAML riskOdds ratioMyeloid leukemiaParental ageChildhood acute myeloid leukemiaPaternal age groupsInfants of mothersConfidence intervalsAdvanced maternal ageMultiple logistic regressionPooled-effect estimatesInfant acute myeloid leukemiaMaternal smokingMultiple gestationsMaternal ageChildhood cancerAML casesAge groupsLogistic regressionStudy designAge incrementsOlder childrenAge
2016
In utero cytomegalovirus infection and development of childhood acute lymphoblastic leukemia
Francis SS, Wallace AD, Wendt GA, Li L, Liu F, Riley LW, Kogan S, Walsh KM, de Smith AJ, Dahl GV, Ma X, Delwart E, Metayer C, Wiemels JL. In utero cytomegalovirus infection and development of childhood acute lymphoblastic leukemia. Blood 2016, 129: 1680-1684. PMID: 27979823, PMCID: PMC5364339, DOI: 10.1182/blood-2016-07-723148.Peer-Reviewed Original ResearchConceptsAcute lymphoblastic leukemiaCMV infectionCytomegalovirus infectionLymphoblastic leukemiaChildhood acute lymphoblastic leukemiaUtero cytomegalovirus infectionCongenital CMV infectionCommon childhood cancerActive viral transcriptionBone marrow specimensNon-Hispanic whitesTiming of infectionNewborn blood samplesEtiologic roleRisk factorsChildhood cancerHealthy controlsHigh prevalenceMarrow specimensLeukemia blastsBlood samplesPrenatal originEtiologic agentInfectionHispanic children
2012
New health conditions identified at a regional childhood cancer survivor clinic visit
Hogan M, Ma X, Kadan‐Lottick N. New health conditions identified at a regional childhood cancer survivor clinic visit. Pediatric Blood & Cancer 2012, 60: 682-687. PMID: 23023769, DOI: 10.1002/pbc.24360.Peer-Reviewed Original ResearchConceptsNew health conditionsClinic visitsSurvivorship clinicChildhood cancerHealth conditionsOdds ratioChildren's Oncology Group Long-Term FollowCancer treatment exposuresRegular medical careCancer diagnosisPotential treatment-related effectsLong-term followCancer survivorship clinicTherapy-related effectsTreatment-related effectsRisk-based screeningGroup of survivorsSurvivor clinicChest irradiationPulmonary dysfunctionSubsequent cancerLate complicationsNeurologic impairmentAssociated FactorsMultivariate regression model
2004
Maternal Dietary Risk Factors in Childhood Acute Lymphoblastic Leukemia (United States)
Jensen CD, Block G, Buffler P, Ma X, Selvin S, Month S. Maternal Dietary Risk Factors in Childhood Acute Lymphoblastic Leukemia (United States). Cancer Causes & Control 2004, 15: 559-570. PMID: 15280635, DOI: 10.1023/b:caco.0000036161.98734.17.Peer-Reviewed Original ResearchConceptsAcute lymphoblastic leukemiaRisk factorsMaternal dietLymphoblastic leukemiaPopulation-based case-control studyChildhood acute lymphoblastic leukemiaConsumption of provitaminMaternal dietary intakeDietary risk factorsFood frequency questionnaireNorthern California Childhood Leukemia StudyCommon childhood cancerMaternal dietary factorsImportant risk factorCase-control studyCalifornia Childhood Leukemia StudyChildhood Leukemia StudyCounty of residenceConsumption of vegetablesDate of birthFrequency questionnaireDietary factorsChildhood cancerDietary intakeCommon cause
2003
Prenatal origin of TEL‐AML1–positive acute lymphoblastic leukemia in children born in California
McHale CM, Wiemels JL, Zhang L, Ma X, Buffler PA, Guo W, Loh ML, Smith MT. Prenatal origin of TEL‐AML1–positive acute lymphoblastic leukemia in children born in California. Genes Chromosomes And Cancer 2003, 37: 36-43. PMID: 12661004, DOI: 10.1002/gcc.10199.Peer-Reviewed Original ResearchConceptsAcute lymphoblastic leukemiaCommon acute lymphoblastic leukemiaLymphoblastic leukemiaTEL-AML1CALL patientsPrenatal originTEL-AML1 gene fusionGuthrie cardsPositive acute lymphoblastic leukemiaSecondary changesTime of diagnosisTEL-AML1 fusionNeonatal Guthrie cardsNeonatal blood spotsClonotypic primersClonotypic sequencesOlder patientsPeak incidenceChildhood cancerRetrospective analysisTEL alleleTrisomy 21Blood spotsLeukemiaPatients