2022
Blood Transcriptomes of SARS-CoV-2–Infected Kidney Transplant Recipients Associated with Immune Insufficiency Proportionate to Severity
Sun Z, Zhang Z, Banu K, Al Azzi Y, Reghuvaran A, Fredericks S, Planoutene M, Hartzell S, Kim Y, Pell J, Tietjen G, Asch W, Kulkarni S, Formica R, Rana M, Maltzman JS, Zhang W, Akalin E, Heeger PS, Cravedi P, Menon MC. Blood Transcriptomes of SARS-CoV-2–Infected Kidney Transplant Recipients Associated with Immune Insufficiency Proportionate to Severity. Journal Of The American Society Of Nephrology 2022, 33: 2108-2122. PMID: 36041788, PMCID: PMC9678030, DOI: 10.1681/asn.2022010125.Peer-Reviewed Original ResearchConceptsKidney transplant recipientsImmune activation pathwaysImmunosuppressant useKTR cohortAcute illnessBlood transcriptomeAcute casesT cellsCOVID-19Most kidney transplant recipientsPost-acute COVID-19Adaptive immune system activationManagement of immunosuppressionReinstitution of immunosuppressionAcute COVID-19Serum inflammatory cytokinesCOVID-19 severity scoreCOVID-19 infectionImmune system activationUpregulation of neutrophilActivation pathwayTransplant recipientsChart reviewImmune signaturesLymphocyte count
2020
Identifying a Kidney Transplant Recipient COVID Phenotype to Aid Test Utilization in the Setting of Limited Testing Availability—Does One Exist?
Virmani S, Gleeson SE, Girone GF, Malhotra D, Cohen EA, Klarman SE, Asch WS. Identifying a Kidney Transplant Recipient COVID Phenotype to Aid Test Utilization in the Setting of Limited Testing Availability—Does One Exist? Transplantation Proceedings 2020, 52: 2584-2591. PMID: 32711848, PMCID: PMC7305913, DOI: 10.1016/j.transproceed.2020.05.033.Peer-Reviewed Original ResearchConceptsKidney transplant recipientsSARS-CoV-2BK viremiaLimited testing availabilityTesting availabilitySevere acute respiratory syndrome 2 virusImmunosuppressed kidney transplant recipientsOutpatient testing centerPolyoma BK viremiaCOVID-19 infectionPositive predictive valueTransplant recipientsImmunocompetent patientsSymptomatic patientsImmunosuppressed patientsTransplant centersHigh morbidityEmergency departmentInpatient treatmentGeneral populationHigh incidencePatientsCenter deliveriesPredictive valueTest utilization