Progression of Gestational Subclinical Hypothyroidism and Hypothyroxinemia to Overt Hypothyroidism After Pregnancy: Pooled Analysis of Data from Two Randomized Controlled Trials
Varner M, Mele L, Casey B, Peaceman A, Reddy U, Wapner R, Thorp J, Saade G, Tita A, Rouse D, Sibai B, Costantine M, Mercer B, Caritis S, Bethesda. Progression of Gestational Subclinical Hypothyroidism and Hypothyroxinemia to Overt Hypothyroidism After Pregnancy: Pooled Analysis of Data from Two Randomized Controlled Trials. Thyroid 2024, 34: 1171-1176. PMID: 39028022, DOI: 10.1089/thy.2023.0616.Peer-Reviewed Original ResearchSubclinical hypothyroidismOvert hypothyroidismAssociated with higher ratesTPO levelsThyroid peroxidaseYear 5Gestational subclinical hypothyroidismNormal free T4Multicenter treatment trialThyroid replacement therapyYear of deliveryThyrotropin (TSHThyroid peroxidase levelsYear 1Randomized controlled trialsWeeks gestationPlacebo groupTSH valuesMaternal serumReplacement therapyFree T4Higher ratesHypothyroxinemiaThyroid functionHypothyroidism