2023
Neonatal Paenibacilliosis: Paenibacillus Infection as a Novel Cause of Sepsis in Term Neonates With High Risk of Sequelae in Uganda
Ericson J, Burgoine K, Kumbakumba E, Ochora M, Hehnly C, Bajunirwe F, Bazira J, Fronterre C, Hagmann C, Kulkarni A, Kumar M, Magombe J, Mbabazi-Kabachelor E, Morton S, Movassagh M, Mugamba J, Mulondo R, Natukwatsa D, Kaaya B, Olupot-Olupot P, Onen J, Sheldon K, Smith J, Ssentongo P, Ssenyonga P, Warf B, Wegoye E, Zhang L, Kiwanuka J, Paulson J, Broach J, Schiff S. Neonatal Paenibacilliosis: Paenibacillus Infection as a Novel Cause of Sepsis in Term Neonates With High Risk of Sequelae in Uganda. Clinical Infectious Diseases 2023, 77: 768-775. PMID: 37279589, PMCID: PMC10495130, DOI: 10.1093/cid/ciad337.Peer-Reviewed Original ResearchMeSH KeywordsAnti-Bacterial AgentsDisease ProgressionFemaleHumansHydrocephalusInfant, NewbornNeonatal SepsisPaenibacillusPregnancySepsisUgandaConceptsNeonatal sepsisPostinfectious hydrocephalusCerebrospinal fluidSigns of sepsisFull-term neonatesOptimal antibiotic treatmentUgandan referral hospitalQuantitative polymerase chain reactionNeonatal characteristicsClinical sepsisTerm neonatesUnderdiagnosed causeAntibiotic choiceMedian ageReferral hospitalUgandan hospitalNeurodevelopmental impairmentAdverse outcomesSpecimen typesAntibiotic treatmentPolymerase chain reactionClinical signsUnusual pathogensSepsisHigh risk
2020
The Problem of Microbial Dark Matter in Neonatal Sepsis - Volume 26, Number 11—November 2020 - Emerging Infectious Diseases journal - CDC
Sinnar S, Schiff S. The Problem of Microbial Dark Matter in Neonatal Sepsis - Volume 26, Number 11—November 2020 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2020, 26: 2543-2548. PMID: 33080169, PMCID: PMC7588532, DOI: 10.3201/eid2611.200004.Peer-Reviewed Original ResearchMeSH KeywordsAnti-Bacterial AgentsBacteriaBlood CultureComputer SimulationHumansInfantNeonatal SepsisPolymerase Chain ReactionConceptsNeonatal sepsisCausative pathogenInfectious Diseases journal - CDCCulture recovery ratesAntimicrobial therapyBlood culturesTimely diagnosisAntimicrobial stewardshipWorldwide deathsMost blood culturesUnidentified pathogensTransmission patternsDeathPathogen discoveryWhole metagenomic sequencingPathogensEffective diagnosticsMetagenomic sequencingSepsisPatientsInfantsTherapyDiagnosisRecovery rate