2023
LRRK2 suppresses lysosome degradative activity in macrophages and microglia through MiT-TFE transcription factor inhibition
Yadavalli N, Ferguson S. LRRK2 suppresses lysosome degradative activity in macrophages and microglia through MiT-TFE transcription factor inhibition. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2303789120. PMID: 37487100, PMCID: PMC10400961, DOI: 10.1073/pnas.2303789120.Peer-Reviewed Original ResearchMeSH KeywordsHumansLeucine-Rich Repeat Serine-Threonine Protein Kinase-2LysosomesMacrophagesMicrogliaParkinson DiseaseTranscription Factors
2022
ER-lysosome lipid transfer protein VPS13C/PARK23 prevents aberrant mtDNA-dependent STING signaling
Hancock-Cerutti W, Wu Z, Xu P, Yadavalli N, Leonzino M, Tharkeshwar AK, Ferguson SM, Shadel GS, De Camilli P. ER-lysosome lipid transfer protein VPS13C/PARK23 prevents aberrant mtDNA-dependent STING signaling. Journal Of Cell Biology 2022, 221: e202106046. PMID: 35657605, PMCID: PMC9170524, DOI: 10.1083/jcb.202106046.Peer-Reviewed Original ResearchMeSH KeywordsDNA, MitochondrialEndoplasmic ReticulumHeLa CellsHumansLeucine-Rich Repeat Serine-Threonine Protein Kinase-2LipidsLysosomesMembrane ProteinsMutationParkinson DiseaseProteinsConceptsParkinson's diseasePD pathogenesisLeucine-rich repeat kinase 2 (LRRK2) G2019S mutationCGAS-STING pathwayAccumulation of lysosomesDNA-sensing cGAS-STING pathwayImmune activationLipid profileSTING signalingG2019S mutationAutosomal recessive Parkinson's diseaseRecessive Parkinson's diseaseModel human cell linesHuman cell linesCell linesPathogenesisLate endosomes/lysosomesDiseaseVPS13CEndosomes/lysosomesCurrent studyTransfer proteinActivationCellsPathway