2024
Randomized Phase II Trial of Imiquimod with or without 9-Valent HPV Vaccine versus Observation in Patients with High-grade Pre-neoplastic Cervical Lesions (NCT02864147)
Sheth S, Oh J, Bellone S, Siegel E, Greenman M, Mutlu L, McNamara B, Pathy S, Clark M, Azodi M, Altwerger G, Andikyan V, Huang G, Ratner E, Kim D, Iwasaki A, Levi A, Buza N, Hui P, Flaherty S, Schwartz P, Santin A. Randomized Phase II Trial of Imiquimod with or without 9-Valent HPV Vaccine versus Observation in Patients with High-grade Pre-neoplastic Cervical Lesions (NCT02864147). Clinical Cancer Research 2024, 30: of1-of10. PMID: 38592381, DOI: 10.1158/1078-0432.ccr-23-3639.Peer-Reviewed Original ResearchConceptsRandomized phase II trialCD4/CD8 T cellsT cellsHPV clearanceArm BNo significant differenceClinical surveillanceRate of HPV clearanceSecondary outcomesPre-neoplastic cervical lesionsCervical intraepithelial neoplasiaT cell infiltrationT cell responsesSignificant differenceCIN3 patientsIntraepithelial neoplasiaArm ACervical lesionsImiquimod groupSurveillance armVaginal suppositoriesProspective trialsArm CHPV vaccinationImiquimod
2021
Unindicated cervical cancer screening in adolescent females within a large healthcare system in the United States
Hosier H, Sheth SS, Oliveira CR, Perley LE, Vash-Margita A. Unindicated cervical cancer screening in adolescent females within a large healthcare system in the United States. American Journal Of Obstetrics And Gynecology 2021, 225: 649.e1-649.e9. PMID: 34256029, PMCID: PMC8633062, DOI: 10.1016/j.ajog.2021.07.005.Peer-Reviewed Original ResearchConceptsCervical cancerLarge healthcare systemYears of ageIncidence rateScreening testAdolescent femalesHealthcare systemLarge multihospital health systemCervical cancer screening resultsNew cervical cancer casesCurrent consensus recommendationsHuman papillomavirus testingHuman papillomavirus vaccinationCervical cancer casesCervical cancer screeningMultihospital health systemCancer risk reductionScreening resultsPoisson regression analysisEvidence-based strategiesGuideline nonadherencePapillomavirus vaccinationCytology testingIntraepithelial lesionsProvider factors